ID   GATZ_KLEOX              Reviewed;         419 AA.
AC   Q8VS12;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=D-tagatose-1,6-bisphosphate aldolase subunit GatZ;
GN   Name=gatZ;
OS   Klebsiella oxytoca.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=571;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN GALACTITOL AND D-TAGATOSE
RP   CATABOLISM, AND INDUCTION.
RC   STRAIN=M5a1;
RX   PubMed=15257457; DOI=10.1007/s00438-004-1022-8;
RA   Shakeri-Garakani A., Brinkkoetter A., Schmid K., Turgut S., Lengeler J.W.;
RT   "The genes and enzymes for the catabolism of galactitol, D-tagatose, and
RT   related carbohydrates in Klebsiella oxytoca M5a1 and other enteric bacteria
RT   display convergent evolution.";
RL   Mol. Genet. Genomics 271:717-728(2004).
CC   -!- FUNCTION: Component of the tagatose-1,6-bisphosphate aldolase GatYZ
CC       that is required for full activity and stability of the Y subunit.
CC       Could have a chaperone-like function for the proper and stable folding
CC       of GatY. When expressed alone, GatZ does not show any aldolase
CC       activity. Is involved in the catabolism of galactitol.
CC       {ECO:0000269|PubMed:15257457}.
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2.
CC   -!- SUBUNIT: Forms a complex with GatY. {ECO:0000250}.
CC   -!- INDUCTION: By galactitol. {ECO:0000269|PubMed:15257457}.
CC   -!- SIMILARITY: Belongs to the GatZ/KbaZ family. GatZ subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF416702; AAL60169.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8VS12; -.
DR   SMR; Q8VS12; -.
DR   STRING; 571.MC52_04985; -.
DR   eggNOG; COG4573; Bacteria.
DR   UniPathway; UPA00704; UER00716.
DR   GO; GO:2001059; P:D-tagatose 6-phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019404; P:galactitol catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_01296; Tagatose_aldol_GatZ; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR012062; GatZ/KbaZ-like.
DR   InterPro; IPR023436; TagBP_ald_GatZ.
DR   Pfam; PF08013; GatZ_KbaZ-like; 1.
DR   PIRSF; PIRSF009264; TagBP_ald_AgaZ; 1.
DR   TIGRFAMs; TIGR02810; agaZ_gatZ; 1.
PE   1: Evidence at protein level;
KW   Galactitol metabolism.
FT   CHAIN           1..419
FT                   /note="D-tagatose-1,6-bisphosphate aldolase subunit GatZ"
FT                   /id="PRO_0000355360"
SQ   SEQUENCE   419 AA;  46646 MW;  FEFFFC16E8616DFC CRC64;
     MKDIISRHKA GEHIGICSVC SAHPLVIEAA LSFDLHTNNK VLIEATSNQV NQFGGYTGMS
     CDFRDFVNKI AREVGFPSER IILGGDHLGP NCWQGEPAAE AMEKSVDLIK AYVAAGFSKI
     HLDASMSCAD DPVPLDPAIV AERAARLCQA AEETATDEQK RHLTYVIGTE VPVPGGEAST
     IGSVHVTRAQ DAAATLETHE AAFRKLGLNA ALERVIAIVV QPGVEFDHTQ IIHYQPEAAK
     ALSAWIEGTP MVYEAHSTDY QSRQAYWALV RDHYAILKVG PALTFALREA IFSLAQMENE
     LVAPESRSRV MEVIDEVMLN EPGYWKKYYR PTWSQAMADI HFSLSDRIRY YWPHPRIRQS
     VEKLIANLTE TKLPLGLISQ YIPVQFERLS LNELAAVPHD LILDKIQDVL RAYRYGRAI