ID   ALL7_DERPT              Reviewed;         215 AA.
AC   P49273;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Mite allergen Der p 7;
DE   AltName: Full=Allergen Der p VII;
DE   AltName: Allergen=Der p 7;
DE   Flags: Precursor;
GN   Name=DERP7;
OS   Dermatophagoides pteronyssinus (European house dust mite).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Analgoidea;
OC   Pyroglyphidae; Dermatophagoidinae; Dermatophagoides.
OX   NCBI_TaxID=6956;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10779281; DOI=10.1111/j.1365-2222.1993.tb00278.x;
RA   Shen H.-D., Chua K.-Y., Lin K.-L., Hsieh K.-H., Thomas W.R.;
RT   "Molecular cloning of a house dust mite allergen with common antibody
RT   binding specificities with multiple components in mite extracts.";
RL   Clin. Exp. Allergy 23:934-940(1993).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Common symptoms of mite
CC       allergy are bronchial asthma, allergic rhinitis and conjunctivitis.
CC   -!- SIMILARITY: Belongs to the mite group 7 allergen family. {ECO:0000305}.
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DR   EMBL; U37044; AAA80264.1; -; mRNA.
DR   PDB; 3H4Z; X-ray; 2.35 A; A/B/C=17-215.
DR   PDBsum; 3H4Z; -.
DR   AlphaFoldDB; P49273; -.
DR   SMR; P49273; -.
DR   Allergome; 321; Der p 7.
DR   Allergome; 3268; Der p 7.0101.
DR   ABCD; P49273; 1 sequenced antibody.
DR   BRENDA; 3.4.22.65; 1873.
DR   EvolutionaryTrace; P49273; -.
DR   Proteomes; UP000515146; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.15.10.50; -; 1.
DR   InterPro; IPR038602; Mite_allergen_7_sf.
DR   InterPro; IPR020234; Mite_allergen_group-7.
DR   Pfam; PF16984; Grp7_allergen; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Allergen; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..215
FT                   /note="Mite allergen Der p 7"
FT                   /id="PRO_0000001185"
FT   CARBOHYD        151
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   HELIX           22..42
FT                   /evidence="ECO:0007829|PDB:3H4Z"
FT   TURN            45..48
FT                   /evidence="ECO:0007829|PDB:3H4Z"
FT   STRAND          49..51
FT                   /evidence="ECO:0007829|PDB:3H4Z"
FT   STRAND          54..59
FT                   /evidence="ECO:0007829|PDB:3H4Z"
FT   STRAND          63..65
FT                   /evidence="ECO:0007829|PDB:3H4Z"
FT   STRAND          68..79
FT                   /evidence="ECO:0007829|PDB:3H4Z"
FT   HELIX           81..83
FT                   /evidence="ECO:0007829|PDB:3H4Z"
FT   STRAND          91..95
FT                   /evidence="ECO:0007829|PDB:3H4Z"
FT   STRAND          98..107
FT                   /evidence="ECO:0007829|PDB:3H4Z"
FT   STRAND          112..120
FT                   /evidence="ECO:0007829|PDB:3H4Z"
FT   STRAND          128..146
FT                   /evidence="ECO:0007829|PDB:3H4Z"
FT   STRAND          152..159
FT                   /evidence="ECO:0007829|PDB:3H4Z"
FT   STRAND          165..169
FT                   /evidence="ECO:0007829|PDB:3H4Z"
FT   HELIX           177..188
FT                   /evidence="ECO:0007829|PDB:3H4Z"
FT   TURN            189..192
FT                   /evidence="ECO:0007829|PDB:3H4Z"
FT   HELIX           193..210
FT                   /evidence="ECO:0007829|PDB:3H4Z"
FT   TURN            211..214
FT                   /evidence="ECO:0007829|PDB:3H4Z"
SQ   SEQUENCE   215 AA;  23881 MW;  63AD03DB5C8CB1C0 CRC64;
     MMKLLLIAAA AFVAVSADPI HYDKITEEIN KAVDEAVAAI EKSETFDPMK VPDHSDKFER
     HIGIIDLKGE LDMRNIQVRG LKQMKRVGDA NVKSEDGVVK AHLLVGVHDD VVSMEYDLAY
     KLGDLHPNTH VISDIQDFVV ELSLEVSEEG NMTLTSFEVR QFANVVNHIG GLSILDPIFA
     VLSDVLTAIF QDTVRAEMTK VLAPAFKKEL ERNNQ