ID   GBB1_CAEBR              Reviewed;         340 AA.
AC   Q61ZF6; A8WSQ6;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Guanine nucleotide-binding protein subunit beta-1;
GN   Name=gpb-1; ORFNames=CBG03131;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=15856303; DOI=10.1007/s00438-004-1105-6;
RA   Jovelin R., Phillips P.C.;
RT   "Functional constraint and divergence in the G protein family in
RT   Caenorhabditis elegans and Caenorhabditis briggsae.";
RL   Mol. Genet. Genomics 273:299-310(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC       as a modulator or transducer in various transmembrane signaling
CC       systems. The beta and gamma chains are required for the GTPase
CC       activity, for replacement of GDP by GTP, and for G protein-effector
CC       interaction. In the early embryo, controls the magnitude of the forces
CC       acting on centrosomes but is not required for generating asymmetric
CC       forces. {ECO:0000250|UniProtKB:P17343}.
CC   -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma.
CC       Interacts with G protein gamma subunits gpc-1 and gpc-2 and with egl-10
CC       and eat-16. Interacts with goa-1 (in GDP-bound form).
CC       {ECO:0000250|UniProtKB:P17343, ECO:0000250|UniProtKB:P63212}.
CC   -!- SIMILARITY: Belongs to the WD repeat G protein beta family.
CC       {ECO:0000305}.
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DR   EMBL; AY634302; AAW02908.1; -; Genomic_DNA.
DR   EMBL; HE601438; CAP23515.1; -; Genomic_DNA.
DR   RefSeq; XP_002631310.1; XM_002631264.1.
DR   AlphaFoldDB; Q61ZF6; -.
DR   SMR; Q61ZF6; -.
DR   STRING; 6238.CBG03131; -.
DR   EnsemblMetazoa; CBG03131.1; CBG03131.1; WBGene00026054.
DR   GeneID; 8572825; -.
DR   KEGG; cbr:CBG_03131; -.
DR   CTD; 8572825; -.
DR   WormBase; CBG03131; CBP00625; WBGene00026054; Cbr-gpb-1.
DR   eggNOG; KOG0286; Eukaryota.
DR   HOGENOM; CLU_000288_57_34_1; -.
DR   InParanoid; Q61ZF6; -.
DR   OMA; PLDSQWV; -.
DR   OrthoDB; 704786at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR   GO; GO:0030159; F:signaling receptor complex adaptor activity; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEA:EnsemblMetazoa.
DR   GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:EnsemblMetazoa.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0040013; P:negative regulation of locomotion; IEA:EnsemblMetazoa.
DR   GO; GO:0046662; P:regulation of oviposition; IEA:EnsemblMetazoa.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR001632; Gprotein_B.
DR   InterPro; IPR016346; Guanine_nucleotide-bd_bsu.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19850; PTHR19850; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00319; GPROTEINB.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Mitosis; Reference proteome; Repeat; Transducer;
KW   WD repeat.
FT   CHAIN           1..340
FT                   /note="Guanine nucleotide-binding protein subunit beta-1"
FT                   /id="PRO_0000127711"
FT   REPEAT          53..83
FT                   /note="WD 1"
FT   REPEAT          95..125
FT                   /note="WD 2"
FT   REPEAT          141..170
FT                   /note="WD 3"
FT   REPEAT          182..212
FT                   /note="WD 4"
FT   REPEAT          224..254
FT                   /note="WD 5"
FT   REPEAT          268..298
FT                   /note="WD 6"
FT   REPEAT          310..340
FT                   /note="WD 7"
SQ   SEQUENCE   340 AA;  37406 MW;  DF83F9C299F124BD CRC64;
     MSELDQLRQE AEQLKSQIRE ARKSANDTTL ATVASNLEPI GRIQMRTRRT LRGHLAKIYA
     MHWASDSRNL VSASQDGKLI VWDSYTTNKV HAIPLRSSWV MTCAYAPSGS FVACGGLDNI
     CSIYSLKTRE GNVRVSRELP GHTGYLSCCR FLDDNQIVTS SGDMTCALWD IETGQQCTAF
     TGHTGDVMSL SLSPDFRTFI SGACDASAKL WDIRDGMCKQ TFPGHESDIN AVAFFPSGNA
     FATGSDDATC RLFDIRADQE LAMYSHDNII CGITSVAFSK SGRLLFAGYD DFNCNVWDSM
     RQERAGVLAG HDNRVSCLGV TEDGMAVCTG SWDSFLKIWN