ID   GBB1_CRIGR              Reviewed;         340 AA.
AC   Q6TMK6;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   29-SEP-2021, entry version 83.
DE   RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;
DE   AltName: Full=Transducin beta chain 1;
GN   Name=GNB1;
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Guang L., Shibuya M., Yoshiro M.;
RT   "Differential display analysis of BCR/ABL-regulated genes.";
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC       as a modulator or transducer in various transmembrane signaling
CC       systems. The beta and gamma chains are required for the GTPase
CC       activity, for replacement of GDP by GTP, and for G protein-effector
CC       interaction.
CC   -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma (By
CC       similarity). The heterodimer formed by GNB1 and GNG2 interacts with
CC       ARHGEF5 (By similarity). The heterodimer formed by GNB1 and GNG2
CC       interacts with GRK2 (By similarity). Interacts with ARHGEF18 and RASD2
CC       (By similarity). {ECO:0000250|UniProtKB:P62871,
CC       ECO:0000250|UniProtKB:P62873}.
CC   -!- PTM: Phosphorylation at His-266 by NDKB contributes to G protein
CC       activation by increasing the high energetic phosphate transfer onto
CC       GDP. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat G protein beta family.
CC       {ECO:0000305}.
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DR   EMBL; AY392427; AAQ94086.1; -; mRNA.
DR   RefSeq; NP_001233630.1; NM_001246701.1.
DR   BioGRID; 1614024; 1.
DR   STRING; 10029.NP_001233630.1; -.
DR   PRIDE; Q6TMK6; -.
DR   GeneID; 100689442; -.
DR   KEGG; cge:100689442; -.
DR   CTD; 2782; -.
DR   eggNOG; KOG0286; Eukaryota.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR001632; Gprotein_B.
DR   InterPro; IPR016346; Guanine_nucleotide-bd_bsu.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19850; PTHR19850; 1.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00319; GPROTEINB.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Phosphoprotein; Repeat; Transducer; WD repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P62873"
FT   CHAIN           2..340
FT                   /note="Guanine nucleotide-binding protein G(I)/G(S)/G(T)
FT                   subunit beta-1"
FT                   /id="PRO_0000127686"
FT   REPEAT          53..83
FT                   /note="WD 1"
FT   REPEAT          95..125
FT                   /note="WD 2"
FT   REPEAT          141..170
FT                   /note="WD 3"
FT   REPEAT          182..212
FT                   /note="WD 4"
FT   REPEAT          224..254
FT                   /note="WD 5"
FT   REPEAT          268..298
FT                   /note="WD 6"
FT   REPEAT          310..340
FT                   /note="WD 7"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:P62873"
FT   MOD_RES         2
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P62873"
FT   MOD_RES         266
FT                   /note="Phosphohistidine"
FT                   /evidence="ECO:0000250|UniProtKB:P62871"
SQ   SEQUENCE   340 AA;  37418 MW;  603D4165D059C37C CRC64;
     MSELDQLRQE AEQLKNQIRD ARKACADATL SXITTNIDPV GRIQMRTRRT LRGHLAKIYA
     MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV MTCAYAPSGN YVACGGLDNI
     CSIYNLKTRE GNVRVSRELA GHTGYLSCCR FLNDNQIVTS SEDTTCALWD IETGQQTTTF
     TGHTGDVMSL SLAPDTRLFV SGACDASAKL WDVREGMCRQ TFTGHESDIN AICFFPNGNA
     FATGSDDATC RLFDLRADQE LMTYSHDNII CGITSVSFSK SGRLLLAGYD DFNCNVWDAL
     KADRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN