GBB2_BOVIN
ID GBB2_BOVIN Reviewed; 340 AA.
AC P11017; A5D7A9;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 3.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;
DE AltName: Full=G protein subunit beta-2;
DE AltName: Full=Transducin beta chain 2;
GN Name=GNB2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Ascending colon;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 15-340.
RX PubMed=3108879; DOI=10.1073/pnas.84.11.3792;
RA Fong H.K.W., Amatruda T.T. III, Birren B.W., Simon M.I.;
RT "Distinct forms of the beta subunit of GTP-binding regulatory proteins
RT identified by molecular cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 84:3792-3796(1987).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 102-316.
RX PubMed=3114742; DOI=10.1073/pnas.84.17.6122;
RA Gao B., Gilman A.G., Robishaw J.D.;
RT "A second form of the beta subunit of signal-transducing G proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 84:6122-6125(1987).
CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC as a modulator or transducer in various transmembrane signaling
CC systems. The beta and gamma chains are required for the GTPase
CC activity, for replacement of GDP by GTP, and for G protein-effector
CC interaction.
CC -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma. In
CC this context, interacts with GNAI2 and GNG2 (By similarity). Interacts
CC with ARHGEF18 and RASD2. Interacts with ATXN10. Interacts with SCN8A.
CC {ECO:0000250|UniProtKB:P62879}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000250|UniProtKB:P62879}. Cell membrane
CC {ECO:0000250|UniProtKB:P62879}.
CC -!- SIMILARITY: Belongs to the WD repeat G protein beta family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC140489; AAI40490.1; -; mRNA.
DR EMBL; M16480; AAA30553.1; -; mRNA.
DR EMBL; M36431; AAA62717.1; -; mRNA.
DR EMBL; M16539; AAA30552.1; -; mRNA.
DR PIR; A26617; RGBOB2.
DR RefSeq; NP_001091030.1; NM_001097561.1.
DR AlphaFoldDB; P11017; -.
DR SMR; P11017; -.
DR STRING; 9913.ENSBTAP00000008508; -.
DR PaxDb; P11017; -.
DR PeptideAtlas; P11017; -.
DR PRIDE; P11017; -.
DR Ensembl; ENSBTAT00000008508; ENSBTAP00000008508; ENSBTAG00000006495.
DR GeneID; 281202; -.
DR KEGG; bta:281202; -.
DR CTD; 2783; -.
DR VEuPathDB; HostDB:ENSBTAG00000006495; -.
DR VGNC; VGNC:29459; GNB2.
DR eggNOG; KOG0286; Eukaryota.
DR GeneTree; ENSGT01000000214413; -.
DR HOGENOM; CLU_000288_57_34_1; -.
DR InParanoid; P11017; -.
DR OMA; HVWDTLR; -.
DR OrthoDB; 704786at2759; -.
DR TreeFam; TF106149; -.
DR Reactome; R-BTA-392170; ADP signalling through P2Y purinoceptor 12.
DR Reactome; R-BTA-392451; G beta:gamma signalling through PI3Kgamma.
DR Reactome; R-BTA-416476; G alpha (q) signalling events.
DR Reactome; R-BTA-418594; G alpha (i) signalling events.
DR Reactome; R-BTA-418597; G alpha (z) signalling events.
DR Reactome; R-BTA-428930; Thromboxane signalling through TP receptor.
DR Reactome; R-BTA-456926; Thrombin signalling through proteinase activated receptors (PARs).
DR Reactome; R-BTA-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR Proteomes; UP000009136; Chromosome 25.
DR Bgee; ENSBTAG00000006495; Expressed in granulosa cell and 106 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IDA:MGI.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR GO; GO:0003924; F:GTPase activity; IDA:MGI.
DR GO; GO:0051020; F:GTPase binding; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0030159; F:signaling receptor complex adaptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:1901379; P:regulation of potassium ion transmembrane transport; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR001632; Gprotein_B.
DR InterPro; IPR016346; Guanine_nucleotide-bd_bsu.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19850; PTHR19850; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00319; GPROTEINB.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cell membrane; Cytoplasm; Membrane; Phosphoprotein;
KW Reference proteome; Repeat; Transducer; WD repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P62879"
FT CHAIN 2..340
FT /note="Guanine nucleotide-binding protein G(I)/G(S)/G(T)
FT subunit beta-2"
FT /id="PRO_0000127694"
FT REPEAT 53..83
FT /note="WD 1"
FT REPEAT 95..125
FT /note="WD 2"
FT REPEAT 141..170
FT /note="WD 3"
FT REPEAT 182..212
FT /note="WD 4"
FT REPEAT 224..254
FT /note="WD 5"
FT REPEAT 268..298
FT /note="WD 6"
FT REPEAT 310..340
FT /note="WD 7"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:P62879"
FT MOD_RES 239
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:P62880"
FT CONFLICT 285
FT /note="L -> V (in Ref. 3; AAA30552)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 340 AA; 37331 MW; 5D08FFA240ADEEE6 CRC64;
MSELEQLRQE AEQLRNQIRD ARKACGDSTL TQITAGLDPV GRIQMRTRRT LRGHLAKIYA
MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV MTCAYAPSGN FVACGGLDNI
CSIYSLKTRE GNVRVSRELP GHTGYLSCCR FLDDNQIITS SGDTTCALWD IETGQQTVGF
AGHSGDVMSL SLAPDGRTFV SGACDASIKL WDVRDSMCRQ TFIGHESDIN AVAFFPNGYA
FTTGSDDATC RLFDLRADQE LLMYSHDNII CGITSVAFSR SGRLLLAGYD DFNCNIWDAM
KGDRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLKIWN
