GBB2_CAEEL
ID GBB2_CAEEL Reviewed; 369 AA.
AC Q20636;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 22-APR-2020, sequence version 3.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Guanine nucleotide-binding protein subunit beta-2;
GN Name=gpb-2 {ECO:0000312|WormBase:F52A8.2a};
GN Synonyms=eat-11 {ECO:0000312|WormBase:F52A8.2a},
GN gbp-2 {ECO:0000312|WormBase:F52A8.2a};
GN ORFNames=F52A8.2 {ECO:0000312|WormBase:F52A8.2a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 14-369, AND INTERACTION WITH GPC-1; GPC-2;
RP EAT-10 AND EAT-16.
RC STRAIN=Bristol N2;
RX PubMed=11333232; DOI=10.1093/genetics/158.1.221;
RA van Der Linden A.M., Simmer F., Cuppen E., Plasterk R.H.A.;
RT "The G protein beta subunit gpb-2 in Caenorhabditis elegans regulates the
RT G(o)alpha-G(q)alpha signaling network through interactions with the
RT regulator of G protein signaling proteins egl-10 and eat-16.";
RL Genetics 158:221-235(2001).
RN [3]
RP FUNCTION, AND MUTAGENESIS OF ALA-130.
RX PubMed=15378064; DOI=10.1038/nn1316;
RA Chase D.L., Pepper J.S., Koelle M.R.;
RT "Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans.";
RL Nat. Neurosci. 7:1096-1103(2004).
CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC as a modulator or transducer in various transmembrane signaling
CC systems. The beta and gamma chains are required for the GTPase
CC activity, for replacement of GDP by GTP, and for G protein-effector
CC interaction. Plays a role in regulating dopamine-mediated locomotion
CC behavior (PubMed:15378064). {ECO:0000269|PubMed:15378064}.
CC -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma (By
CC similarity). Interacts with G protein gamma subunits gpc-1 and gpc-2
CC and with egl-10 and eat-16 (PubMed:11333232).
CC {ECO:0000250|UniProtKB:P63212, ECO:0000269|PubMed:11333232}.
CC -!- SIMILARITY: Belongs to the WD repeat G protein beta family.
CC {ECO:0000305}.
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DR EMBL; AF291847; AAK55964.1; -; mRNA.
DR EMBL; BX284601; CAA95824.2; -; Genomic_DNA.
DR PIR; T22478; T22478.
DR RefSeq; NP_492072.2; NM_059671.6.
DR AlphaFoldDB; Q20636; -.
DR SMR; Q20636; -.
DR BioGRID; 37925; 11.
DR STRING; 6239.F52A8.2; -.
DR EPD; Q20636; -.
DR PaxDb; Q20636; -.
DR PeptideAtlas; Q20636; -.
DR EnsemblMetazoa; F52A8.2a.1; F52A8.2a.1; WBGene00001680.
DR GeneID; 172483; -.
DR KEGG; cel:CELE_F52A8.2; -.
DR UCSC; F52A8.2; c. elegans.
DR CTD; 172483; -.
DR WormBase; F52A8.2a; CE50400; WBGene00001680; gpb-2.
DR eggNOG; KOG0286; Eukaryota.
DR GeneTree; ENSGT01000000214413; -.
DR HOGENOM; CLU_000288_57_34_1; -.
DR InParanoid; Q20636; -.
DR OMA; WVMACSY; -.
DR OrthoDB; 704786at2759; -.
DR PhylomeDB; Q20636; -.
DR Reactome; R-CEL-1296041; Activation of G protein gated Potassium channels.
DR Reactome; R-CEL-202040; G-protein activation.
DR Reactome; R-CEL-392170; ADP signalling through P2Y purinoceptor 12.
DR Reactome; R-CEL-392451; G beta:gamma signalling through PI3Kgamma.
DR Reactome; R-CEL-400042; Adrenaline,noradrenaline inhibits insulin secretion.
DR Reactome; R-CEL-4086398; Ca2+ pathway.
DR Reactome; R-CEL-416476; G alpha (q) signalling events.
DR Reactome; R-CEL-416482; G alpha (12/13) signalling events.
DR Reactome; R-CEL-418555; G alpha (s) signalling events.
DR Reactome; R-CEL-418594; G alpha (i) signalling events.
DR Reactome; R-CEL-418597; G alpha (z) signalling events.
DR Reactome; R-CEL-428930; Thromboxane signalling through TP receptor.
DR Reactome; R-CEL-456926; Thrombin signalling through proteinase activated receptors (PARs).
DR Reactome; R-CEL-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR Reactome; R-CEL-8964616; G beta:gamma signalling through CDC42.
DR Reactome; R-CEL-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
DR PRO; PR:Q20636; -.
DR Proteomes; UP000001940; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR GO; GO:0043025; C:neuronal cell body; IDA:WormBase.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0030159; F:signaling receptor complex adaptor activity; IBA:GO_Central.
DR GO; GO:0007212; P:dopamine receptor signaling pathway; IMP:WormBase.
DR GO; GO:0007631; P:feeding behavior; IMP:WormBase.
DR GO; GO:0007213; P:G protein-coupled acetylcholine receptor signaling pathway; IMP:WormBase.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:UniProtKB.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IGI:WormBase.
DR GO; GO:0040012; P:regulation of locomotion; IMP:WormBase.
DR GO; GO:0046662; P:regulation of oviposition; IMP:WormBase.
DR GO; GO:0043051; P:regulation of pharyngeal pumping; IMP:WormBase.
DR GO; GO:0032094; P:response to food; IMP:WormBase.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR001632; Gprotein_B.
DR InterPro; IPR016346; Guanine_nucleotide-bd_bsu.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19850; PTHR19850; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00319; GPROTEINB.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; Transducer; WD repeat.
FT CHAIN 1..369
FT /note="Guanine nucleotide-binding protein subunit beta-2"
FT /id="PRO_0000127713"
FT REPEAT 79..109
FT /note="WD 1"
FT REPEAT 121..151
FT /note="WD 2"
FT REPEAT 167..197
FT /note="WD 3"
FT REPEAT 209..241
FT /note="WD 4"
FT REPEAT 253..283
FT /note="WD 5"
FT REPEAT 297..327
FT /note="WD 6"
FT REPEAT 339..369
FT /note="WD 7"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 130
FT /note="A->T: Defective dopamine signaling."
FT /evidence="ECO:0000269|PubMed:15378064"
SQ SEQUENCE 369 AA; 40707 MW; 3D8C304EE61508F1 CRC64;
MSTIAGESSS SSKMPENSQP TTTEKGSEYL EQLANEAEEL RKKLDQERHK LNDIPIQQAA
ERLDVMGALG VKQRRILKGH VGKVLCMDWS LDKRHIVSSS QDGKVIVWDG FTTNKEHALT
MPTTWVMACA FSPSSQMIAC GGLDNKCSVV PLSFEDDIIQ KKRQVATHTS YMSCCTFLRS
DNLILTGSGD STCAIWDVES GQLIQNFHGH TGDVFAIDVP KCDTGNTFIS AGADKHSLVW
DIRSGQCVQS FEGHEADINT VRFHPNGDAF ATGSDDATCR LFDLRADRQV CVYEKESILF
PVNGVDFSLS GRILFAGYGD YRVGVWDSLK CARHSVLYGH ENRISCLRTS PDGTAVCSAS
WDCTIRIWA
