ID   GBB3_CANLF              Reviewed;         340 AA.
AC   P79147; Q0PY31;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;
DE   AltName: Full=Transducin beta chain 3;
GN   Name=GNB3;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Alaskan malamute; TISSUE=Retina;
RX   PubMed=9266671; DOI=10.1016/s0378-1119(97)00134-0;
RA   Akhmedov N.B., Piriev N.I., Ray K., Acland G.M., Aguirre G.D., Farber D.B.;
RT   "Structure and analysis of the transducin beta3-subunit gene, a candidate
RT   for inherited cone degeneration (cd) in the dog.";
RL   Gene 194:47-56(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Kuppinger O., Fischer E., Schulz R.;
RT   "Primary hypertension in dog is not associated with polymorphism in exon 9
RT   of the GNB3 gene.";
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Blood;
RA   Kuppinger O., Fischer E., Ammer H.;
RT   "GNB3 allele variance, primary hypertension and diabetes mellitus in dog.";
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC       as a modulator or transducer in various transmembrane signaling
CC       systems. The beta and gamma chains are required for the GTPase
CC       activity, for replacement of GDP by GTP, and for G protein-effector
CC       interaction.
CC   -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma.
CC       Interacts with RASD2 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat G protein beta family.
CC       {ECO:0000305}.
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DR   EMBL; U52916; AAC48760.1; -; mRNA.
DR   EMBL; AY751537; AAU95209.1; -; Genomic_DNA.
DR   EMBL; DQ672621; ABG57070.1; -; mRNA.
DR   RefSeq; NP_001003004.1; NM_001003004.1.
DR   AlphaFoldDB; P79147; -.
DR   SMR; P79147; -.
DR   STRING; 9612.ENSCAFP00000021609; -.
DR   PaxDb; P79147; -.
DR   Ensembl; ENSCAFT00030040673; ENSCAFP00030035502; ENSCAFG00030022113.
DR   GeneID; 403511; -.
DR   KEGG; cfa:403511; -.
DR   CTD; 2784; -.
DR   eggNOG; KOG0286; Eukaryota.
DR   InParanoid; P79147; -.
DR   Reactome; R-CFA-1296041; Activation of G protein gated Potassium channels.
DR   Reactome; R-CFA-202040; G-protein activation.
DR   Reactome; R-CFA-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR   Reactome; R-CFA-381771; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
DR   Reactome; R-CFA-392170; ADP signalling through P2Y purinoceptor 12.
DR   Reactome; R-CFA-392451; G beta:gamma signalling through PI3Kgamma.
DR   Reactome; R-CFA-400042; Adrenaline,noradrenaline inhibits insulin secretion.
DR   Reactome; R-CFA-4086398; Ca2+ pathway.
DR   Reactome; R-CFA-416476; G alpha (q) signalling events.
DR   Reactome; R-CFA-416482; G alpha (12/13) signalling events.
DR   Reactome; R-CFA-418217; G beta:gamma signalling through PLC beta.
DR   Reactome; R-CFA-418555; G alpha (s) signalling events.
DR   Reactome; R-CFA-418592; ADP signalling through P2Y purinoceptor 1.
DR   Reactome; R-CFA-418594; G alpha (i) signalling events.
DR   Reactome; R-CFA-418597; G alpha (z) signalling events.
DR   Reactome; R-CFA-420092; Glucagon-type ligand receptors.
DR   Reactome; R-CFA-428930; Thromboxane signalling through TP receptor.
DR   Reactome; R-CFA-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR   Reactome; R-CFA-456926; Thrombin signalling through proteinase activated receptors (PARs).
DR   Reactome; R-CFA-500657; Presynaptic function of Kainate receptors.
DR   Reactome; R-CFA-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR   Reactome; R-CFA-8964315; G beta:gamma signalling through BTK.
DR   Reactome; R-CFA-8964616; G beta:gamma signalling through CDC42.
DR   Reactome; R-CFA-9009391; Extra-nuclear estrogen signaling.
DR   Reactome; R-CFA-9634597; GPER1 signaling.
DR   Reactome; R-CFA-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR   Reactome; R-CFA-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR001632; Gprotein_B.
DR   InterPro; IPR016346; Guanine_nucleotide-bd_bsu.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19850; PTHR19850; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00319; GPROTEINB.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Repeat; Transducer; WD repeat.
FT   CHAIN           1..340
FT                   /note="Guanine nucleotide-binding protein G(I)/G(S)/G(T)
FT                   subunit beta-3"
FT                   /id="PRO_0000127698"
FT   REPEAT          53..83
FT                   /note="WD 1"
FT   REPEAT          95..125
FT                   /note="WD 2"
FT   REPEAT          141..170
FT                   /note="WD 3"
FT   REPEAT          182..212
FT                   /note="WD 4"
FT   REPEAT          224..254
FT                   /note="WD 5"
FT   REPEAT          268..298
FT                   /note="WD 6"
FT   REPEAT          310..340
FT                   /note="WD 7"
SQ   SEQUENCE   340 AA;  37144 MW;  8E3B5A5238E29C37 CRC64;
     MGEMEQLRQE AEQLKKQIAD ARKACADTTL AELVSGLEVV GRVQMRTRRT LRGHLAKIYA
     MHWATDSKLL VSASQDGKLI VWDTYTTNKV HAIPLRSSWV MTCAYAPSGN FVACGGLDNM
     CSIYSLKSRE GNVKVSRELS AHTGYLSCCR FLDDNNIVTS SGDTTCALWD IETGQQKTVF
     VGHTGDCMSL AVSPDFKLFI SGACDASAKL WDVREGTCRQ TFTGHESDIN AICFFPNGEA
     ICTGSDDASC RLFDLRADQE LTAYSDESII CGITSVAFSL SGRLLFAGYD DFNCNIWDSM
     KGERVGILSG HDNRVSCLGV TADGMAVATG SWDSFLKVWN