GBB4_RAT
ID GBB4_RAT Reviewed; 340 AA.
AC O35353; Q4V8I8; Q6Q8B2;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 4.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Guanine nucleotide-binding protein subunit beta-4;
DE AltName: Full=Transducin beta chain 4;
GN Name=Gnb4;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar; TISSUE=Brain;
RA Puhl H.L. III, Ikeda S.R.;
RT "Cloning and characterization of the rat G-protein beta 4 subunit.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 321-340, AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=9622245; DOI=10.1016/s0306-4522(97)00623-4;
RA Betty M., Harnish S.W., Rhodes K.J., Cockett M.I.;
RT "Distribution of heterotrimeric G-protein beta and gamma subunits in the
RT rat brain.";
RL Neuroscience 85:475-486(1998).
CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC as a modulator or transducer in various transmembrane signaling
CC systems. The beta and gamma chains are required for the GTPase
CC activity, for replacement of GDP by GTP, and for G protein-effector
CC interaction.
CC -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma.
CC -!- TISSUE SPECIFICITY: Widely expressed in the brain. Highest levels found
CC in the hippocampus and layers v and vi of the neocortex.
CC {ECO:0000269|PubMed:9622245}.
CC -!- SIMILARITY: Belongs to the WD repeat G protein beta family.
CC {ECO:0000305}.
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DR EMBL; AY552804; AAS59142.1; -; mRNA.
DR EMBL; BC097370; AAH97370.1; -; mRNA.
DR EMBL; AF022085; AAB82552.1; -; mRNA.
DR RefSeq; NP_001013932.1; NM_001013910.2.
DR AlphaFoldDB; O35353; -.
DR SMR; O35353; -.
DR BioGRID; 254841; 2.
DR IntAct; O35353; 3.
DR MINT; O35353; -.
DR STRING; 10116.ENSRNOP00000014871; -.
DR iPTMnet; O35353; -.
DR PhosphoSitePlus; O35353; -.
DR SwissPalm; O35353; -.
DR jPOST; O35353; -.
DR PRIDE; O35353; -.
DR Ensembl; ENSRNOT00000087803; ENSRNOP00000074669; ENSRNOG00000011070.
DR GeneID; 294962; -.
DR KEGG; rno:294962; -.
DR UCSC; RGD:1359321; rat.
DR CTD; 59345; -.
DR RGD; 1359321; Gnb4.
DR eggNOG; KOG0286; Eukaryota.
DR GeneTree; ENSGT01000000214413; -.
DR InParanoid; O35353; -.
DR OrthoDB; 704786at2759; -.
DR Reactome; R-RNO-1296041; Activation of G protein gated Potassium channels.
DR Reactome; R-RNO-202040; G-protein activation.
DR Reactome; R-RNO-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR Reactome; R-RNO-392170; ADP signalling through P2Y purinoceptor 12.
DR Reactome; R-RNO-392451; G beta:gamma signalling through PI3Kgamma.
DR Reactome; R-RNO-400042; Adrenaline,noradrenaline inhibits insulin secretion.
DR Reactome; R-RNO-4086398; Ca2+ pathway.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR Reactome; R-RNO-418597; G alpha (z) signalling events.
DR Reactome; R-RNO-420092; Glucagon-type ligand receptors.
DR Reactome; R-RNO-428930; Thromboxane signalling through TP receptor.
DR Reactome; R-RNO-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR Reactome; R-RNO-456926; Thrombin signalling through proteinase activated receptors (PARs).
DR Reactome; R-RNO-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR Reactome; R-RNO-8964616; G beta:gamma signalling through CDC42.
DR Reactome; R-RNO-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
DR PRO; PR:O35353; -.
DR Proteomes; UP000002494; Chromosome 2.
DR GO; GO:0044297; C:cell body; IDA:RGD.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; ISO:RGD.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:RGD.
DR GO; GO:0030159; F:signaling receptor complex adaptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR001632; Gprotein_B.
DR InterPro; IPR016346; Guanine_nucleotide-bd_bsu.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19850; PTHR19850; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00319; GPROTEINB.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Phosphoprotein; Reference proteome; Repeat; Transducer;
KW WD repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9HAV0"
FT CHAIN 2..340
FT /note="Guanine nucleotide-binding protein subunit beta-4"
FT /id="PRO_0000127704"
FT REPEAT 53..92
FT /note="WD 1"
FT REPEAT 95..134
FT /note="WD 2"
FT REPEAT 141..179
FT /note="WD 3"
FT REPEAT 182..221
FT /note="WD 4"
FT REPEAT 224..263
FT /note="WD 5"
FT REPEAT 268..307
FT /note="WD 6"
FT REPEAT 310..339
FT /note="WD 7"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:Q9HAV0"
FT MOD_RES 2
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P62873"
FT MOD_RES 266
FT /note="Phosphohistidine"
FT /evidence="ECO:0000250|UniProtKB:P62871"
SQ SEQUENCE 340 AA; 37363 MW; F06827F2256E8966 CRC64;
MSELEQLRQE AEQLRNQIQD ARKACNDATL VQITSNMDSV GRIQMRTRRT LRGHLAKIYA
MHWGYDSRLL VSASQDGKLI IWDSYTTNKM HAIPLRSSWV MTCAYAPSGN YVACGGLDNI
CSIYNLKTRE GNVRVSRELP GHTGYLSCCR FLDDGQIITS SGDTTCALWD IETGQQTTTF
TGHSGDVMSL SLSPDLKTFV SGACDASSKL WDIRDGMCRQ SFTGHISDIN AVSFFPSGYA
FATGSDDATC RLFDLRADQE LLLYSHDNII CGITSVAFSK SGRLLLAGYD DFNCSVWDAL
KGGRAGVLAG HDNRVSCLGV TDDGMAVATG SWDSFLRIWN
