ID   GBB_LOLFO               Reviewed;         341 AA.
AC   P23232;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Guanine nucleotide-binding protein subunit beta;
OS   Loligo forbesii (Veined squid).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Cephalopoda;
OC   Coleoidea; Decapodiformes; Teuthida; Myopsina; Loliginidae; Loligo.
OX   NCBI_TaxID=6618;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RX   PubMed=1899186; DOI=10.1042/bj2730225;
RA   Ryba N.J.P., Pottinger J.D.D., Keen J.N., Findlay J.B.C.;
RT   "Sequence of the beta-subunit of the phosphatidylinositol-specific
RT   phospholipase C-directed GTP-binding protein from squid (Loligo forbesi)
RT   photoreceptors.";
RL   Biochem. J. 273:225-228(1991).
CC   -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC       as a modulator or transducer in various transmembrane signaling
CC       systems. The beta and gamma chains are required for the GTPase
CC       activity, for replacement of GDP by GTP, and for G protein-effector
CC       interaction.
CC   -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma.
CC   -!- SIMILARITY: Belongs to the WD repeat G protein beta family.
CC       {ECO:0000305}.
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DR   EMBL; X56757; CAA40077.1; -; mRNA.
DR   PIR; S13302; RGOOBE.
DR   AlphaFoldDB; P23232; -.
DR   SMR; P23232; -.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR001632; Gprotein_B.
DR   InterPro; IPR016346; Guanine_nucleotide-bd_bsu.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19850; PTHR19850; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00319; GPROTEINB.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Repeat; Transducer; WD repeat.
FT   CHAIN           1..341
FT                   /note="Guanine nucleotide-binding protein subunit beta"
FT                   /id="PRO_0000127717"
FT   REPEAT          54..84
FT                   /note="WD 1"
FT   REPEAT          96..126
FT                   /note="WD 2"
FT   REPEAT          142..171
FT                   /note="WD 3"
FT   REPEAT          183..213
FT                   /note="WD 4"
FT   REPEAT          225..255
FT                   /note="WD 5"
FT   REPEAT          269..299
FT                   /note="WD 6"
FT   REPEAT          311..341
FT                   /note="WD 7"
SQ   SEQUENCE   341 AA;  37323 MW;  9A338AC9C2D742C3 CRC64;
     MTSELEALRQ ETEQLKNQIR EARKAAADTT LAMATANVEP VGRIQMRTRR TLRGHLAKIY
     AMHWASDSRN LVSASQDGKL IVWDGYTTNK VHAIPLRSSW VMTCAYAPSG NYVACGGLDN
     ICSIYSLKTR EGNVRVSREL PGHTGYLSCC RFIDDNQIVT SSGDMTCALW NIETGNQITS
     FGGHTGDVMS LSLAPDMRTF VSGACDASAK LFDIRDGICK QTFTGHESDI NAITYFPNGF
     AFATGSDDAT CRLFDIRADQ EIGMYSHDNI ICGITSVAFS KSGRLLLGGY DDFNCNVWDV
     LKQERAGVLA GHDNRVSCLG VTEDGMAVAT GSWDSFLKIW N