ID   3NO56_BUNMU             Reviewed;          89 AA.
AC   O12963;
DT   25-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Long neurotoxin homolog TA-bm16;
DE   AltName: Full=Delta-protein;
DE   Flags: Precursor;
OS   Bungarus multicinctus (Many-banded krait).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Bungarinae; Bungarus.
OX   NCBI_TaxID=8616;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=9350342; DOI=10.1080/15216549700204131;
RA   Chang L.-S., Lin J.;
RT   "cDNA sequence analysis of a neurotoxin homology from Taiwan banded
RT   krait.";
RL   Biochem. Mol. Biol. Int. 43:347-354(1997).
CC   -!- FUNCTION: Exhibits M2 muscarinic acetylcholine receptor (CHRM2)-
CC       blocking activity, but has a weak binding activity toward nicotinic
CC       AChR. Moreover, it inhibits collagen-induced platelet aggregation.
CC       {ECO:0000250|UniProtKB:Q9YGJ0}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Ancestral
CC       subfamily. Orphan group V sub-subfamily. {ECO:0000305}.
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DR   EMBL; Y12267; CAA72941.1; -; mRNA.
DR   AlphaFoldDB; O12963; -.
DR   SMR; O12963; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR035076; Toxin/TOLIP.
DR   Pfam; PF00087; Toxin_TOLIP; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   3: Inferred from homology;
KW   Cell adhesion impairing toxin; Disulfide bond;
KW   G-protein coupled acetylcholine receptor impairing toxin;
KW   G-protein coupled receptor impairing toxin; Hemostasis impairing toxin;
KW   Neurotoxin; Platelet aggregation inhibiting toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..89
FT                   /note="Long neurotoxin homolog TA-bm16"
FT                   /id="PRO_0000035429"
FT   DISULFID        24..45
FT                   /evidence="ECO:0000250|UniProtKB:P81782"
FT   DISULFID        27..32
FT                   /evidence="ECO:0000250|UniProtKB:P81782"
FT   DISULFID        38..66
FT                   /evidence="ECO:0000250|UniProtKB:P81782"
FT   DISULFID        70..81
FT                   /evidence="ECO:0000250|UniProtKB:P81782"
FT   DISULFID        82..87
FT                   /evidence="ECO:0000250|UniProtKB:P81782"
SQ   SEQUENCE   89 AA;  9756 MW;  839AC6FFF69D0481 CRC64;
     MKTLLLTLVV VTIVCLDLGY TMQCKTCSFY TCPNSETCPD GKNICVKRSW TAVAGDGLKR
     EIRRECAATC PPSKLGLTVF CCTTDNCNH