GBG1_HUMAN
ID GBG1_HUMAN Reviewed; 74 AA.
AC P63211; A4D1H2; O43835; Q08447; Q16026; Q6LCP6;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Guanine nucleotide-binding protein G(T) subunit gamma-T1;
DE AltName: Full=Transducin gamma chain;
DE Flags: Precursor;
GN Name=GNGT1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=8500562; DOI=10.1006/exer.1993.1063;
RA Tao L., Pandey S., Simon M.I., Fong H.K.;
RT "Structure of the bovine transducin gamma subunit gene and analysis of
RT promoter function in transgenic mice.";
RL Exp. Eye Res. 56:497-507(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Blood;
RX PubMed=8661128; DOI=10.1006/geno.1996.0346;
RA Scherer S.W., Feinstein D.S., Oliveira L., Tsui L.-C., Pittler S.J.;
RT "Gene structure and chromosome localization to 7q21.3 of the human rod
RT photoreceptor transducin gamma-subunit gene (GNGT1).";
RL Genomics 35:241-243(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC as a modulator or transducer in various transmembrane signaling
CC systems. The beta and gamma chains are required for the GTPase
CC activity, for replacement of GDP by GTP, and for G protein-effector
CC interaction.
CC -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma.
CC -!- INTERACTION:
CC P63211; Q9H8Y8: GORASP2; NbExp=5; IntAct=EBI-10220715, EBI-739467;
CC P63211; Q8NCY6: MSANTD4; NbExp=3; IntAct=EBI-10220715, EBI-7850168;
CC P63211; Q92575: UBXN4; NbExp=3; IntAct=EBI-10220715, EBI-723441;
CC P63211; G5E9M4: ZNF277; NbExp=3; IntAct=EBI-10220715, EBI-11995620;
CC P63211; Q8WWA6: ZNF277; NbExp=3; IntAct=EBI-10220715, EBI-10192794;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Retinal rod outer segment.
CC -!- SIMILARITY: Belongs to the G protein gamma family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; S62027; AAB26896.1; -; mRNA.
DR EMBL; S62026; AAD13931.1; -; Genomic_DNA.
DR EMBL; U41492; AAB92386.1; -; Genomic_DNA.
DR EMBL; U41493; AAB92387.1; -; Genomic_DNA.
DR EMBL; AF493869; AAM12583.1; -; mRNA.
DR EMBL; CR456912; CAG33193.1; -; mRNA.
DR EMBL; AC002076; AAS02021.1; -; Genomic_DNA.
DR EMBL; CH236949; EAL24139.1; -; Genomic_DNA.
DR EMBL; CH471091; EAW76806.1; -; Genomic_DNA.
DR EMBL; BC029367; AAH29367.1; -; mRNA.
DR CCDS; CCDS5633.1; -.
DR PIR; I62760; I62760.
DR RefSeq; NP_001316355.1; NM_001329426.1.
DR RefSeq; NP_068774.1; NM_021955.4.
DR PDB; 7L0P; EM; 4.10 A; G=2-74.
DR PDB; 7L0Q; EM; 4.30 A; G=2-74.
DR PDB; 7L0R; EM; 4.20 A; G=2-74.
DR PDB; 7L0S; EM; 4.50 A; G=2-74.
DR PDBsum; 7L0P; -.
DR PDBsum; 7L0Q; -.
DR PDBsum; 7L0R; -.
DR PDBsum; 7L0S; -.
DR AlphaFoldDB; P63211; -.
DR SMR; P63211; -.
DR BioGRID; 109054; 21.
DR CORUM; P63211; -.
DR DIP; DIP-471N; -.
DR IntAct; P63211; 10.
DR STRING; 9606.ENSP00000248572; -.
DR iPTMnet; P63211; -.
DR PhosphoSitePlus; P63211; -.
DR BioMuta; GNGT1; -.
DR DMDM; 52783592; -.
DR MassIVE; P63211; -.
DR PaxDb; P63211; -.
DR PeptideAtlas; P63211; -.
DR PRIDE; P63211; -.
DR ProteomicsDB; 57506; -.
DR Antibodypedia; 30066; 89 antibodies from 22 providers.
DR DNASU; 2792; -.
DR Ensembl; ENST00000248572.10; ENSP00000248572.5; ENSG00000127928.13.
DR Ensembl; ENST00000429473.1; ENSP00000388777.1; ENSG00000127928.13.
DR GeneID; 2792; -.
DR KEGG; hsa:2792; -.
DR MANE-Select; ENST00000248572.10; ENSP00000248572.5; NM_021955.5; NP_068774.1.
DR UCSC; uc003unc.2; human.
DR CTD; 2792; -.
DR DisGeNET; 2792; -.
DR GeneCards; GNGT1; -.
DR HGNC; HGNC:4411; GNGT1.
DR HPA; ENSG00000127928; Tissue enriched (retina).
DR MIM; 189970; gene.
DR neXtProt; NX_P63211; -.
DR OpenTargets; ENSG00000127928; -.
DR PharmGKB; PA28790; -.
DR VEuPathDB; HostDB:ENSG00000127928; -.
DR eggNOG; KOG4119; Eukaryota.
DR GeneTree; ENSGT01050000244876; -.
DR HOGENOM; CLU_168377_2_0_1; -.
DR InParanoid; P63211; -.
DR OMA; CEEVMEY; -.
DR OrthoDB; 1573820at2759; -.
DR PhylomeDB; P63211; -.
DR TreeFam; TF319909; -.
DR PathwayCommons; P63211; -.
DR Reactome; R-HSA-1296041; Activation of G protein gated Potassium channels.
DR Reactome; R-HSA-202040; G-protein activation.
DR Reactome; R-HSA-2485179; Activation of the phototransduction cascade.
DR Reactome; R-HSA-2514859; Inactivation, recovery and regulation of the phototransduction cascade.
DR Reactome; R-HSA-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR Reactome; R-HSA-392170; ADP signalling through P2Y purinoceptor 12.
DR Reactome; R-HSA-392451; G beta:gamma signalling through PI3Kgamma.
DR Reactome; R-HSA-392851; Prostacyclin signalling through prostacyclin receptor.
DR Reactome; R-HSA-400042; Adrenaline,noradrenaline inhibits insulin secretion.
DR Reactome; R-HSA-4086398; Ca2+ pathway.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR Reactome; R-HSA-416482; G alpha (12/13) signalling events.
DR Reactome; R-HSA-418217; G beta:gamma signalling through PLC beta.
DR Reactome; R-HSA-418555; G alpha (s) signalling events.
DR Reactome; R-HSA-418592; ADP signalling through P2Y purinoceptor 1.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR Reactome; R-HSA-418597; G alpha (z) signalling events.
DR Reactome; R-HSA-420092; Glucagon-type ligand receptors.
DR Reactome; R-HSA-428930; Thromboxane signalling through TP receptor.
DR Reactome; R-HSA-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR Reactome; R-HSA-456926; Thrombin signalling through proteinase activated receptors (PARs).
DR Reactome; R-HSA-500657; Presynaptic function of Kainate receptors.
DR Reactome; R-HSA-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR Reactome; R-HSA-8964315; G beta:gamma signalling through BTK.
DR Reactome; R-HSA-8964616; G beta:gamma signalling through CDC42.
DR Reactome; R-HSA-9009391; Extra-nuclear estrogen signaling.
DR Reactome; R-HSA-9634597; GPER1 signaling.
DR Reactome; R-HSA-9660821; ADORA2B mediated anti-inflammatory cytokines production.
DR Reactome; R-HSA-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
DR SignaLink; P63211; -.
DR SIGNOR; P63211; -.
DR BioGRID-ORCS; 2792; 16 hits in 1034 CRISPR screens.
DR ChiTaRS; GNGT1; human.
DR GeneWiki; GNGT1; -.
DR GenomeRNAi; 2792; -.
DR Pharos; P63211; Tbio.
DR PRO; PR:P63211; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; P63211; protein.
DR Bgee; ENSG00000127928; Expressed in pigmented layer of retina and 43 other tissues.
DR ExpressionAtlas; P63211; baseline and differential.
DR Genevisible; P63211; HS.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR GO; GO:0097381; C:photoreceptor disc membrane; TAS:Reactome.
DR GO; GO:0001917; C:photoreceptor inner segment; IEA:Ensembl.
DR GO; GO:0031681; F:G-protein beta-subunit binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; TAS:ProtInc.
DR GO; GO:0010659; P:cardiac muscle cell apoptotic process; IEA:Ensembl.
DR GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
DR GO; GO:0042462; P:eye photoreceptor cell development; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007602; P:phototransduction; IEA:Ensembl.
DR GO; GO:0008104; P:protein localization; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; NAS:ProtInc.
DR CDD; cd00068; GGL; 1.
DR Gene3D; 4.10.260.10; -; 1.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR001770; Gprotein-gamma.
DR PANTHER; PTHR13809; PTHR13809; 1.
DR Pfam; PF00631; G-gamma; 1.
DR PRINTS; PR00321; GPROTEING.
DR SMART; SM00224; GGL; 1.
DR SUPFAM; SSF48670; SSF48670; 1.
DR PROSITE; PS50058; G_PROTEIN_GAMMA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Lipoprotein; Membrane; Methylation;
KW Prenylation; Reference proteome; Transducer.
FT CHAIN 1..71
FT /note="Guanine nucleotide-binding protein G(T) subunit
FT gamma-T1"
FT /id="PRO_0000012605"
FT PROPEP 72..74
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000012606"
FT MOD_RES 71
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 71
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000250"
FT VARIANT 50
FT /note="E -> K (in dbSNP:rs17243826)"
FT /id="VAR_033949"
SQ SEQUENCE 74 AA; 8496 MW; B12B42BE00DB1C05 CRC64;
MPVINIEDLT EKDKLKMEVD QLKKEVTLER MLVSKCCEEV RDYVEERSGE DPLVKGIPED
KNPFKELKGG CVIS
