GBG2_HUMAN
ID GBG2_HUMAN Reviewed; 71 AA.
AC P59768; Q5JPE2; Q6P9A9;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 180.
DE RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2;
DE AltName: Full=G gamma-I;
DE Flags: Precursor;
GN Name=GNG2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=10833460; DOI=10.1006/bbrc.2000.2832;
RA Modarressi M.H., Taylor K.E., Wolfe J.;
RT "Cloning, characterization, and mapping of the gene encoding the human G
RT protein gamma 2 subunit.";
RL Biochem. Biophys. Res. Commun. 272:610-615(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP INTERACTION WITH ARHGEF5.
RX PubMed=19713215; DOI=10.1074/jbc.m109.047282;
RA Wang Z., Kumamoto Y., Wang P., Gan X., Lehmann D., Smrcka A.V., Cohn L.,
RA Iwasaki A., Li L., Wu D.;
RT "Regulation of immature dendritic cell migration by RhoA guanine nucleotide
RT exchange factor Arhgef5.";
RL J. Biol. Chem. 284:28599-28606(2009).
RN [8]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [9]
RP INTERACTION WITH GNB2.
RX PubMed=28219978; DOI=10.1161/circresaha.116.310112;
RA Stallmeyer B., Kuss J., Kotthoff S., Zumhagen S., Vowinkel K., Rinne S.,
RA Matschke L.A., Friedrich C., Schulze-Bahr E., Rust S., Seebohm G.,
RA Decher N., Schulze-Bahr E.;
RT "A Mutation in the G-Protein Gene GNB2 Causes Familial Sinus Node and
RT Atrioventricular Conduction Dysfunction.";
RL Circ. Res. 120:e33-e44(2017).
RN [10]
RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) IN COMPLEX WITH GNB1.
RX PubMed=18611381; DOI=10.1016/j.str.2008.04.010;
RA Johnston C.A., Kimple A.J., Giguere P.M., Siderovski D.P.;
RT "Structure of the parathyroid hormone receptor C terminus bound to the G-
RT protein dimer Gbeta1gamma2.";
RL Structure 16:1086-1094(2008).
RN [11]
RP ERRATUM OF PUBMED:18611381, AND RETRACTION NOTICE OF PUBMED:18611381.
RX PubMed=21827955; DOI=10.1016/j.str.2011.07.010;
RA Johnston C.A., Kimple A.J., Giguere P.M., Siderovski D.P.;
RL Structure 19:1200-1200(2011).
RN [12] {ECO:0007744|PDB:7RKX, ECO:0007744|PDB:7RKY}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS) OF 2-68 IN COMPLEX WITH
RP HOST GNAI1; GNB1 AND HHV-5 US27, AND STRUCTURE BY ELECTRON MICROSCOPY (3.50
RP ANGSTROMS) OF 2-68 IN COMPLEX WITH GNB1; GNA11; CX3CL1 AND HHV-5 US28.
RX PubMed=35061538; DOI=10.1126/sciadv.abl5442;
RA Tsutsumi N., Maeda S., Qu Q., Voegele M., Jude K.M., Suomivuori C.M.,
RA Panova O., Waghray D., Kato H.E., Velasco A., Dror R.O., Skiniotis G.,
RA Kobilka B.K., Garcia K.C.;
RT "Atypical structural snapshots of human cytomegalovirus GPCR interactions
RT with host G proteins.";
RL Sci. Adv. 8:eabl5442-eabl5442(2022).
CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC as a modulator or transducer in various transmembrane signaling
CC systems. The beta and gamma chains are required for the GTPase
CC activity, for replacement of GDP by GTP, and for G protein-effector
CC interaction (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma (By
CC similarity). In this context, interacts with GNB2 (PubMed:28219978).
CC The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5
CC (PubMed:19713215). The heterodimer formed by GNB1 and GNG2 interacts
CC with GRK2 (By similarity). {ECO:0000250|UniProtKB:P63212,
CC ECO:0000269|PubMed:19713215, ECO:0000269|PubMed:28219978}.
CC -!- INTERACTION:
CC P59768; P62873: GNB1; NbExp=6; IntAct=EBI-602681, EBI-357130;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in fetal tissues, including testis,
CC adrenal gland, brain, white blood cells and brain.
CC {ECO:0000269|PubMed:10833460}.
CC -!- SIMILARITY: Belongs to the G protein gamma family. {ECO:0000305}.
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DR EMBL; AF493870; AAM12584.1; -; mRNA.
DR EMBL; AL832878; CAI46198.1; -; mRNA.
DR EMBL; CH471078; EAW65663.1; -; Genomic_DNA.
DR EMBL; BC020774; AAH20774.1; -; mRNA.
DR EMBL; BC060856; AAH60856.1; -; mRNA.
DR CCDS; CCDS32082.1; -.
DR PIR; JC7290; GNG2.
DR RefSeq; NP_001230702.1; NM_001243773.1.
DR RefSeq; NP_001230703.1; NM_001243774.1.
DR RefSeq; NP_444292.1; NM_053064.4.
DR RefSeq; XP_006720236.1; XM_006720173.2.
DR RefSeq; XP_011535148.1; XM_011536846.2.
DR RefSeq; XP_016876865.1; XM_017021376.1.
DR RefSeq; XP_016876866.1; XM_017021377.1.
DR PDB; 4KFM; X-ray; 3.45 A; G=1-68.
DR PDB; 5HE0; X-ray; 2.56 A; G=1-71.
DR PDB; 5HE1; X-ray; 3.15 A; G=1-71.
DR PDB; 5HE2; X-ray; 2.79 A; G=1-71.
DR PDB; 5HE3; X-ray; 2.74 A; G=1-71.
DR PDB; 5UKK; X-ray; 2.60 A; G=8-64.
DR PDB; 5UKL; X-ray; 2.15 A; G=8-69.
DR PDB; 5UKM; X-ray; 3.03 A; G=1-71.
DR PDB; 5UZ7; EM; 4.10 A; G=1-68.
DR PDB; 6B3J; EM; 3.30 A; G=1-71.
DR PDB; 6CRK; X-ray; 2.00 A; G=1-71.
DR PDB; 6D9H; EM; 3.60 A; G=1-71.
DR PDB; 6DDE; EM; 3.50 A; C=1-71.
DR PDB; 6DDF; EM; 3.50 A; C=1-71.
DR PDB; 6E3Y; EM; 3.30 A; G=1-71.
DR PDB; 6EG8; X-ray; 2.80 A; C/E/G/H=1-71.
DR PDB; 6G79; EM; 3.78 A; G=1-71.
DR PDB; 6GDG; EM; 4.11 A; C=1-71.
DR PDB; 6K41; EM; 2.90 A; G=1-71.
DR PDB; 6K42; EM; 4.10 A; G=1-71.
DR PDB; 6KPF; EM; 2.90 A; C=1-71.
DR PDB; 6KPG; EM; 3.00 A; C=1-71.
DR PDB; 6LFM; EM; 3.50 A; C=1-71.
DR PDB; 6LFO; EM; 3.40 A; C=1-71.
DR PDB; 6LI3; EM; 3.32 A; G=1-71.
DR PDB; 6LMK; EM; 3.70 A; C=1-71.
DR PDB; 6LML; EM; 3.90 A; C=1-71.
DR PDB; 6M1H; EM; 3.60 A; D=1-71.
DR PDB; 6M1I; EM; 3.50 A; D=1-71.
DR PDB; 6M8S; X-ray; 3.71 A; E/F/I/J/L=1-71.
DR PDB; 6N4B; EM; 3.00 A; C=1-71.
DR PDB; 6NI3; EM; 3.80 A; G=1-71.
DR PDB; 6NIY; EM; 3.34 A; G=1-71.
DR PDB; 6OIJ; EM; 3.30 A; G=1-71.
DR PDB; 6OIK; EM; 3.60 A; G=1-71.
DR PDB; 6OMM; EM; 3.17 A; C=2-68.
DR PDB; 6ORV; EM; 3.00 A; GP=1-71.
DR PDB; 6OS9; EM; 3.00 A; C=1-71.
DR PDB; 6OSA; EM; 3.00 A; C=1-71.
DR PDB; 6OT0; EM; 3.90 A; G=1-71.
DR PDB; 6P9X; EM; 2.91 A; G=1-71.
DR PDB; 6P9Y; EM; 3.01 A; G=1-71.
DR PDB; 6PB0; EM; 3.00 A; G=1-71.
DR PDB; 6PB1; EM; 2.80 A; G=1-71.
DR PDB; 6PT0; EM; 3.20 A; C=1-68.
DR PDB; 6UUN; EM; 3.00 A; G=1-71.
DR PDB; 6UUS; EM; 2.40 A; G=1-71.
DR PDB; 6UVA; EM; 2.30 A; G=1-71.
DR PDB; 6VCB; EM; 3.30 A; G=1-71.
DR PDB; 6VMS; EM; 3.80 A; C=2-71.
DR PDB; 6VN7; EM; 3.20 A; G=1-71.
DR PDB; 6WHA; EM; 3.36 A; D=1-71.
DR PDB; 6WHC; EM; 3.40 A; C=1-71.
DR PDB; 6WI9; EM; 4.30 A; G=1-71.
DR PDB; 6WPW; EM; 3.10 A; G=1-71.
DR PDB; 6WWZ; EM; 3.34 A; Y=1-68.
DR PDB; 6WZG; EM; 2.30 A; G=1-71.
DR PDB; 6X18; EM; 2.10 A; G=5-62.
DR PDB; 6X19; EM; 2.10 A; G=5-62.
DR PDB; 6X1A; EM; 2.50 A; G=5-62.
DR PDB; 6XBJ; EM; 3.88 A; G=1-71.
DR PDB; 6XBK; EM; 3.24 A; G=1-71.
DR PDB; 6XBL; EM; 3.90 A; G=1-71.
DR PDB; 6XBM; EM; 3.15 A; G=1-71.
DR PDB; 6XOX; EM; 3.10 A; G=1-71.
DR PDB; 7AUE; EM; 2.97 A; G=1-71.
DR PDB; 7BB6; EM; 4.20 A; F=1-71.
DR PDB; 7BB7; EM; 4.40 A; F=1-71.
DR PDB; 7C2E; EM; 4.20 A; G=1-71.
DR PDB; 7CFM; EM; 3.00 A; G=5-62.
DR PDB; 7CFN; EM; 3.00 A; G=5-62.
DR PDB; 7CKW; EM; 3.22 A; G=1-71.
DR PDB; 7CKX; EM; 3.54 A; G=1-71.
DR PDB; 7CKY; EM; 3.20 A; G=1-71.
DR PDB; 7CKZ; EM; 3.10 A; G=1-71.
DR PDB; 7CMU; EM; 3.00 A; C=1-71.
DR PDB; 7CMV; EM; 2.70 A; C=1-71.
DR PDB; 7CRH; EM; 3.30 A; G=1-71.
DR PDB; 7CX2; EM; 2.80 A; G=1-71.
DR PDB; 7CX3; EM; 2.80 A; G=1-71.
DR PDB; 7CX4; EM; 2.90 A; G=1-71.
DR PDB; 7D76; EM; 3.10 A; G=1-71.
DR PDB; 7D77; EM; 2.90 A; G=1-71.
DR PDB; 7D7M; EM; 3.30 A; C=1-71.
DR PDB; 7DFL; EM; 3.30 A; G=5-62.
DR PDB; 7E14; EM; 2.90 A; G=1-71.
DR PDB; 7E2X; EM; 3.00 A; G=1-71.
DR PDB; 7E2Y; EM; 3.00 A; G=1-71.
DR PDB; 7E2Z; EM; 3.10 A; G=1-71.
DR PDB; 7E32; EM; 2.90 A; G=1-71.
DR PDB; 7E33; EM; 2.90 A; G=1-71.
DR PDB; 7E9G; EM; 3.50 A; C=1-71.
DR PDB; 7E9H; EM; 4.00 A; C=1-71.
DR PDB; 7EB2; EM; 3.50 A; Y=1-71.
DR PDB; 7EJ0; EM; 3.20 A; G=1-71.
DR PDB; 7EJ8; EM; 3.00 A; G=1-71.
DR PDB; 7EJA; EM; 3.60 A; G=1-71.
DR PDB; 7EJK; EM; 3.40 A; G=1-71.
DR PDB; 7EJX; EM; 2.40 A; G=1-71.
DR PDB; 7EO2; EM; 2.89 A; D=1-71.
DR PDB; 7EO4; EM; 2.86 A; D=1-71.
DR PDB; 7EVW; EM; 3.22 A; C=1-71.
DR PDB; 7EVY; EM; 2.98 A; C=1-71.
DR PDB; 7EVZ; EM; 3.07 A; C=1-71.
DR PDB; 7EW0; EM; 3.42 A; C=1-71.
DR PDB; 7EW1; EM; 3.40 A; C=1-71.
DR PDB; 7EW2; EM; 3.10 A; C=1-71.
DR PDB; 7EW3; EM; 3.10 A; C=1-71.
DR PDB; 7EW4; EM; 3.20 A; C=1-71.
DR PDB; 7EW7; EM; 3.27 A; C=1-71.
DR PDB; 7EXD; EM; 3.40 A; G=1-71.
DR PDB; 7EZH; EM; 3.20 A; G=1-71.
DR PDB; 7EZK; EM; 3.10 A; G=1-71.
DR PDB; 7EZM; EM; 2.90 A; G=1-71.
DR PDB; 7F1Q; EM; 2.90 A; C=1-71.
DR PDB; 7F1R; EM; 3.00 A; C=1-71.
DR PDB; 7F1S; EM; 2.80 A; C=1-71.
DR PDB; 7F4D; EM; 3.00 A; G=1-71.
DR PDB; 7F4F; EM; 2.90 A; G=1-71.
DR PDB; 7F4H; EM; 2.70 A; G=1-71.
DR PDB; 7F4I; EM; 3.10 A; G=1-71.
DR PDB; 7F53; EM; 3.00 A; G=1-71.
DR PDB; 7F54; EM; 3.00 A; G=1-71.
DR PDB; 7F55; EM; 3.10 A; G=1-71.
DR PDB; 7F58; EM; 3.10 A; G=1-71.
DR PDB; 7F6H; EM; 2.90 A; D=2-71.
DR PDB; 7F6I; EM; 2.80 A; D=2-71.
DR PDB; 7F8V; EM; 3.30 A; C=1-71.
DR PDB; 7F8W; EM; 3.10 A; C=1-71.
DR PDB; 7F9Y; EM; 2.90 A; G=1-71.
DR PDB; 7F9Z; EM; 3.20 A; G=1-71.
DR PDB; 7JHJ; EM; 3.20 A; C=2-68.
DR PDB; 7JOZ; X-ray; 3.80 A; G=1-71.
DR PDB; 7JV5; EM; 3.00 A; G=2-68.
DR PDB; 7JVP; EM; 2.90 A; G=2-68.
DR PDB; 7JVQ; EM; 3.00 A; G=2-68.
DR PDB; 7JVR; EM; 2.80 A; C=1-71.
DR PDB; 7K7L; X-ray; 2.54 A; G=6-64.
DR PDB; 7K7Z; X-ray; 2.61 A; G=6-64.
DR PDB; 7KH0; EM; 2.80 A; G=2-68.
DR PDB; 7KI0; EM; 2.50 A; G=5-62.
DR PDB; 7KI1; EM; 2.50 A; G=5-62.
DR PDB; 7L1U; EM; 3.20 A; C=1-71.
DR PDB; 7L1V; EM; 3.00 A; C=1-71.
DR PDB; 7LCI; EM; 2.90 A; G=5-62.
DR PDB; 7LD3; EM; 3.20 A; G=1-71.
DR PDB; 7LD4; EM; 3.30 A; G=1-71.
DR PDB; 7LLL; EM; 3.70 A; G=5-62.
DR PDB; 7LLY; EM; 3.30 A; G=5-62.
DR PDB; 7MBX; EM; 1.95 A; G=1-71.
DR PDB; 7MBY; EM; 2.44 A; G=1-71.
DR PDB; 7MTS; EM; 3.20 A; E=1-71.
DR PDB; 7NA7; EM; 2.70 A; G=1-71.
DR PDB; 7NA8; EM; 2.70 A; G=1-71.
DR PDB; 7P00; EM; 2.71 A; G=1-71.
DR PDB; 7P02; EM; 2.87 A; G=1-71.
DR PDB; 7RA3; EM; 3.24 A; G=1-71.
DR PDB; 7RBT; EM; 3.08 A; G=1-71.
DR PDB; 7RG9; EM; 3.20 A; G=1-71.
DR PDB; 7RGP; EM; 2.90 A; G=1-71.
DR PDB; 7RKF; EM; 4.00 A; C=2-68.
DR PDB; 7RKM; EM; 3.50 A; C=2-68.
DR PDB; 7RKN; EM; 3.60 A; C=2-68.
DR PDB; 7RKX; EM; 3.10 A; C=2-68.
DR PDB; 7RKY; EM; 3.80 A; C=2-68.
DR PDB; 7RMG; EM; 3.00 A; G=1-68.
DR PDB; 7RMH; EM; 3.10 A; G=1-68.
DR PDB; 7RMI; EM; 3.20 A; G=1-68.
DR PDB; 7RTB; EM; 2.14 A; G=5-62.
DR PDB; 7S1M; EM; 2.41 A; G=5-62.
DR PDB; 7S3I; EM; 2.51 A; G=5-62.
DR PDB; 7S8L; EM; 2.45 A; D=1-71.
DR PDB; 7S8M; EM; 2.54 A; D=1-71.
DR PDB; 7S8N; EM; 2.90 A; D=1-71.
DR PDB; 7S8O; EM; 2.58 A; D=1-71.
DR PDB; 7S8P; EM; 2.60 A; D=1-71.
DR PDB; 7T10; EM; 2.50 A; C=1-71.
DR PDB; 7T11; EM; 2.70 A; C=1-71.
DR PDB; 7T6B; EM; 3.19 A; D=1-71.
DR PDB; 7TUZ; EM; 3.12 A; C=1-71.
DR PDB; 7TYF; EM; 2.20 A; G=1-71.
DR PDB; 7TYH; EM; 3.30 A; G=1-71.
DR PDB; 7TYI; EM; 3.30 A; G=1-71.
DR PDB; 7TYL; EM; 3.30 A; G=1-71.
DR PDB; 7TYN; EM; 2.60 A; G=1-71.
DR PDB; 7TYO; EM; 2.70 A; G=1-71.
DR PDB; 7TYW; EM; 3.00 A; G=1-71.
DR PDB; 7TYX; EM; 2.55 A; G=1-71.
DR PDB; 7TYY; EM; 3.00 A; G=1-71.
DR PDB; 7TZF; EM; 2.40 A; G=1-71.
DR PDB; 7VDH; EM; 2.90 A; G=5-62.
DR PDB; 7VDL; EM; 3.22 A; C=5-62.
DR PDB; 7VDM; EM; 2.98 A; G=5-62.
DR PDB; 7VGX; EM; 3.20 A; G=1-71.
DR PDB; 7VKT; EM; 2.90 A; D=1-71.
DR PDB; 7VL8; EM; 2.90 A; G=1-71.
DR PDB; 7VL9; EM; 2.60 A; G=1-71.
DR PDB; 7VLA; EM; 2.70 A; G=1-71.
DR PDB; 7VUG; EM; 3.20 A; C=1-71.
DR PDB; 7VUH; EM; 3.22 A; G=1-71.
DR PDB; 7VUI; EM; 3.30 A; G=1-71.
DR PDB; 7VUJ; EM; 3.80 A; G=1-71.
DR PDB; 7VUY; EM; 2.84 A; G=5-62.
DR PDB; 7VUZ; EM; 2.89 A; G=5-62.
DR PDB; 7VV3; EM; 2.97 A; G=5-62.
DR PDB; 7VV5; EM; 2.76 A; G=5-62.
DR PDB; 7W2Z; EM; 2.80 A; G=1-71.
DR PDB; 7WF7; EM; 3.40 A; D=1-71.
DR PDB; 7WVU; EM; 3.30 A; C=1-71.
DR PDB; 7WVV; EM; 2.90 A; C=1-71.
DR PDB; 7WVW; EM; 3.10 A; C=1-71.
DR PDB; 7WVX; EM; 2.80 A; C=1-71.
DR PDB; 7WVY; EM; 3.00 A; C=1-71.
DR PDBsum; 4KFM; -.
DR PDBsum; 5HE0; -.
DR PDBsum; 5HE1; -.
DR PDBsum; 5HE2; -.
DR PDBsum; 5HE3; -.
DR PDBsum; 5UKK; -.
DR PDBsum; 5UKL; -.
DR PDBsum; 5UKM; -.
DR PDBsum; 5UZ7; -.
DR PDBsum; 6B3J; -.
DR PDBsum; 6CRK; -.
DR PDBsum; 6D9H; -.
DR PDBsum; 6DDE; -.
DR PDBsum; 6DDF; -.
DR PDBsum; 6E3Y; -.
DR PDBsum; 6EG8; -.
DR PDBsum; 6G79; -.
DR PDBsum; 6GDG; -.
DR PDBsum; 6K41; -.
DR PDBsum; 6K42; -.
DR PDBsum; 6KPF; -.
DR PDBsum; 6KPG; -.
DR PDBsum; 6LFM; -.
DR PDBsum; 6LFO; -.
DR PDBsum; 6LI3; -.
DR PDBsum; 6LMK; -.
DR PDBsum; 6LML; -.
DR PDBsum; 6M1H; -.
DR PDBsum; 6M1I; -.
DR PDBsum; 6M8S; -.
DR PDBsum; 6N4B; -.
DR PDBsum; 6NI3; -.
DR PDBsum; 6NIY; -.
DR PDBsum; 6OIJ; -.
DR PDBsum; 6OIK; -.
DR PDBsum; 6OMM; -.
DR PDBsum; 6ORV; -.
DR PDBsum; 6OS9; -.
DR PDBsum; 6OSA; -.
DR PDBsum; 6OT0; -.
DR PDBsum; 6P9X; -.
DR PDBsum; 6P9Y; -.
DR PDBsum; 6PB0; -.
DR PDBsum; 6PB1; -.
DR PDBsum; 6PT0; -.
DR PDBsum; 6UUN; -.
DR PDBsum; 6UUS; -.
DR PDBsum; 6UVA; -.
DR PDBsum; 6VCB; -.
DR PDBsum; 6VMS; -.
DR PDBsum; 6VN7; -.
DR PDBsum; 6WHA; -.
DR PDBsum; 6WHC; -.
DR PDBsum; 6WI9; -.
DR PDBsum; 6WPW; -.
DR PDBsum; 6WWZ; -.
DR PDBsum; 6WZG; -.
DR PDBsum; 6X18; -.
DR PDBsum; 6X19; -.
DR PDBsum; 6X1A; -.
DR PDBsum; 6XBJ; -.
DR PDBsum; 6XBK; -.
DR PDBsum; 6XBL; -.
DR PDBsum; 6XBM; -.
DR PDBsum; 6XOX; -.
DR PDBsum; 7AUE; -.
DR PDBsum; 7BB6; -.
DR PDBsum; 7BB7; -.
DR PDBsum; 7C2E; -.
DR PDBsum; 7CFM; -.
DR PDBsum; 7CFN; -.
DR PDBsum; 7CKW; -.
DR PDBsum; 7CKX; -.
DR PDBsum; 7CKY; -.
DR PDBsum; 7CKZ; -.
DR PDBsum; 7CMU; -.
DR PDBsum; 7CMV; -.
DR PDBsum; 7CRH; -.
DR PDBsum; 7CX2; -.
DR PDBsum; 7CX3; -.
DR PDBsum; 7CX4; -.
DR PDBsum; 7D76; -.
DR PDBsum; 7D77; -.
DR PDBsum; 7D7M; -.
DR PDBsum; 7DFL; -.
DR PDBsum; 7E14; -.
DR PDBsum; 7E2X; -.
DR PDBsum; 7E2Y; -.
DR PDBsum; 7E2Z; -.
DR PDBsum; 7E32; -.
DR PDBsum; 7E33; -.
DR PDBsum; 7E9G; -.
DR PDBsum; 7E9H; -.
DR PDBsum; 7EB2; -.
DR PDBsum; 7EJ0; -.
DR PDBsum; 7EJ8; -.
DR PDBsum; 7EJA; -.
DR PDBsum; 7EJK; -.
DR PDBsum; 7EJX; -.
DR PDBsum; 7EO2; -.
DR PDBsum; 7EO4; -.
DR PDBsum; 7EVW; -.
DR PDBsum; 7EVY; -.
DR PDBsum; 7EVZ; -.
DR PDBsum; 7EW0; -.
DR PDBsum; 7EW1; -.
DR PDBsum; 7EW2; -.
DR PDBsum; 7EW3; -.
DR PDBsum; 7EW4; -.
DR PDBsum; 7EW7; -.
DR PDBsum; 7EXD; -.
DR PDBsum; 7EZH; -.
DR PDBsum; 7EZK; -.
DR PDBsum; 7EZM; -.
DR PDBsum; 7F1Q; -.
DR PDBsum; 7F1R; -.
DR PDBsum; 7F1S; -.
DR PDBsum; 7F4D; -.
DR PDBsum; 7F4F; -.
DR PDBsum; 7F4H; -.
DR PDBsum; 7F4I; -.
DR PDBsum; 7F53; -.
DR PDBsum; 7F54; -.
DR PDBsum; 7F55; -.
DR PDBsum; 7F58; -.
DR PDBsum; 7F6H; -.
DR PDBsum; 7F6I; -.
DR PDBsum; 7F8V; -.
DR PDBsum; 7F8W; -.
DR PDBsum; 7F9Y; -.
DR PDBsum; 7F9Z; -.
DR PDBsum; 7JHJ; -.
DR PDBsum; 7JOZ; -.
DR PDBsum; 7JV5; -.
DR PDBsum; 7JVP; -.
DR PDBsum; 7JVQ; -.
DR PDBsum; 7JVR; -.
DR PDBsum; 7K7L; -.
DR PDBsum; 7K7Z; -.
DR PDBsum; 7KH0; -.
DR PDBsum; 7KI0; -.
DR PDBsum; 7KI1; -.
DR PDBsum; 7L1U; -.
DR PDBsum; 7L1V; -.
DR PDBsum; 7LCI; -.
DR PDBsum; 7LD3; -.
DR PDBsum; 7LD4; -.
DR PDBsum; 7LLL; -.
DR PDBsum; 7LLY; -.
DR PDBsum; 7MBX; -.
DR PDBsum; 7MBY; -.
DR PDBsum; 7MTS; -.
DR PDBsum; 7NA7; -.
DR PDBsum; 7NA8; -.
DR PDBsum; 7P00; -.
DR PDBsum; 7P02; -.
DR PDBsum; 7RA3; -.
DR PDBsum; 7RBT; -.
DR PDBsum; 7RG9; -.
DR PDBsum; 7RGP; -.
DR PDBsum; 7RKF; -.
DR PDBsum; 7RKM; -.
DR PDBsum; 7RKN; -.
DR PDBsum; 7RKX; -.
DR PDBsum; 7RKY; -.
DR PDBsum; 7RMG; -.
DR PDBsum; 7RMH; -.
DR PDBsum; 7RMI; -.
DR PDBsum; 7RTB; -.
DR PDBsum; 7S1M; -.
DR PDBsum; 7S3I; -.
DR PDBsum; 7S8L; -.
DR PDBsum; 7S8M; -.
DR PDBsum; 7S8N; -.
DR PDBsum; 7S8O; -.
DR PDBsum; 7S8P; -.
DR PDBsum; 7T10; -.
DR PDBsum; 7T11; -.
DR PDBsum; 7T6B; -.
DR PDBsum; 7TUZ; -.
DR PDBsum; 7TYF; -.
DR PDBsum; 7TYH; -.
DR PDBsum; 7TYI; -.
DR PDBsum; 7TYL; -.
DR PDBsum; 7TYN; -.
DR PDBsum; 7TYO; -.
DR PDBsum; 7TYW; -.
DR PDBsum; 7TYX; -.
DR PDBsum; 7TYY; -.
DR PDBsum; 7TZF; -.
DR PDBsum; 7VDH; -.
DR PDBsum; 7VDL; -.
DR PDBsum; 7VDM; -.
DR PDBsum; 7VGX; -.
DR PDBsum; 7VKT; -.
DR PDBsum; 7VL8; -.
DR PDBsum; 7VL9; -.
DR PDBsum; 7VLA; -.
DR PDBsum; 7VUG; -.
DR PDBsum; 7VUH; -.
DR PDBsum; 7VUI; -.
DR PDBsum; 7VUJ; -.
DR PDBsum; 7VUY; -.
DR PDBsum; 7VUZ; -.
DR PDBsum; 7VV3; -.
DR PDBsum; 7VV5; -.
DR PDBsum; 7W2Z; -.
DR PDBsum; 7WF7; -.
DR PDBsum; 7WVU; -.
DR PDBsum; 7WVV; -.
DR PDBsum; 7WVW; -.
DR PDBsum; 7WVX; -.
DR PDBsum; 7WVY; -.
DR AlphaFoldDB; P59768; -.
DR SMR; P59768; -.
DR BioGRID; 119933; 58.
DR CORUM; P59768; -.
DR DIP; DIP-33949N; -.
DR IntAct; P59768; 20.
DR MINT; P59768; -.
DR STRING; 9606.ENSP00000334448; -.
DR BindingDB; P59768; -.
DR ChEMBL; CHEMBL3883319; -.
DR DrugBank; DB01159; Halothane.
DR iPTMnet; P59768; -.
DR PhosphoSitePlus; P59768; -.
DR BioMuta; GNG2; -.
DR DMDM; 32699499; -.
DR EPD; P59768; -.
DR jPOST; P59768; -.
DR MassIVE; P59768; -.
DR MaxQB; P59768; -.
DR PaxDb; P59768; -.
DR PeptideAtlas; P59768; -.
DR PRIDE; P59768; -.
DR ProteomicsDB; 57156; -.
DR Antibodypedia; 198; 148 antibodies from 27 providers.
DR DNASU; 54331; -.
DR Ensembl; ENST00000335281.8; ENSP00000334448.4; ENSG00000186469.9.
DR Ensembl; ENST00000554736.5; ENSP00000452014.1; ENSG00000186469.9.
DR Ensembl; ENST00000555472.5; ENSP00000451102.1; ENSG00000186469.9.
DR Ensembl; ENST00000556752.2; ENSP00000451576.1; ENSG00000186469.9.
DR Ensembl; ENST00000556766.6; ENSP00000451231.1; ENSG00000186469.9.
DR Ensembl; ENST00000615906.4; ENSP00000484021.1; ENSG00000186469.9.
DR GeneID; 54331; -.
DR KEGG; hsa:54331; -.
DR MANE-Select; ENST00000556766.6; ENSP00000451231.1; NM_053064.5; NP_444292.1.
DR UCSC; uc001wzi.4; human.
DR CTD; 54331; -.
DR DisGeNET; 54331; -.
DR GeneCards; GNG2; -.
DR HGNC; HGNC:4404; GNG2.
DR HPA; ENSG00000186469; Tissue enhanced (testis).
DR MIM; 606981; gene.
DR neXtProt; NX_P59768; -.
DR OpenTargets; ENSG00000186469; -.
DR PharmGKB; PA28784; -.
DR VEuPathDB; HostDB:ENSG00000186469; -.
DR eggNOG; KOG4119; Eukaryota.
DR GeneTree; ENSGT01050000244876; -.
DR HOGENOM; CLU_168377_0_1_1; -.
DR InParanoid; P59768; -.
DR PhylomeDB; P59768; -.
DR TreeFam; TF319909; -.
DR PathwayCommons; P59768; -.
DR Reactome; R-HSA-1296041; Activation of G protein gated Potassium channels.
DR Reactome; R-HSA-163359; Glucagon signaling in metabolic regulation.
DR Reactome; R-HSA-202040; G-protein activation.
DR Reactome; R-HSA-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR Reactome; R-HSA-392170; ADP signalling through P2Y purinoceptor 12.
DR Reactome; R-HSA-392451; G beta:gamma signalling through PI3Kgamma.
DR Reactome; R-HSA-392851; Prostacyclin signalling through prostacyclin receptor.
DR Reactome; R-HSA-400042; Adrenaline,noradrenaline inhibits insulin secretion.
DR Reactome; R-HSA-4086398; Ca2+ pathway.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR Reactome; R-HSA-416482; G alpha (12/13) signalling events.
DR Reactome; R-HSA-418217; G beta:gamma signalling through PLC beta.
DR Reactome; R-HSA-418555; G alpha (s) signalling events.
DR Reactome; R-HSA-418592; ADP signalling through P2Y purinoceptor 1.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR Reactome; R-HSA-418597; G alpha (z) signalling events.
DR Reactome; R-HSA-420092; Glucagon-type ligand receptors.
DR Reactome; R-HSA-428930; Thromboxane signalling through TP receptor.
DR Reactome; R-HSA-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR Reactome; R-HSA-456926; Thrombin signalling through proteinase activated receptors (PARs).
DR Reactome; R-HSA-500657; Presynaptic function of Kainate receptors.
DR Reactome; R-HSA-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR Reactome; R-HSA-8964315; G beta:gamma signalling through BTK.
DR Reactome; R-HSA-8964616; G beta:gamma signalling through CDC42.
DR Reactome; R-HSA-9009391; Extra-nuclear estrogen signaling.
DR Reactome; R-HSA-9634597; GPER1 signaling.
DR Reactome; R-HSA-9660821; ADORA2B mediated anti-inflammatory cytokines production.
DR Reactome; R-HSA-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
DR SignaLink; P59768; -.
DR SIGNOR; P59768; -.
DR BioGRID-ORCS; 54331; 13 hits in 1075 CRISPR screens.
DR ChiTaRS; GNG2; human.
DR EvolutionaryTrace; P59768; -.
DR GeneWiki; GNG2; -.
DR GenomeRNAi; 54331; -.
DR Pharos; P59768; Tbio.
DR PRO; PR:P59768; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; P59768; protein.
DR Bgee; ENSG00000186469; Expressed in cortical plate and 173 other tissues.
DR ExpressionAtlas; P59768; baseline and differential.
DR Genevisible; P59768; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; ISS:BHF-UCL.
DR GO; GO:0016020; C:membrane; ISS:BHF-UCL.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0031681; F:G-protein beta-subunit binding; IPI:UniProtKB.
DR GO; GO:0007191; P:adenylate cyclase-activating dopamine receptor signaling pathway; ISS:BHF-UCL.
DR GO; GO:0071870; P:cellular response to catecholamine stimulus; ISS:BHF-UCL.
DR GO; GO:0071380; P:cellular response to prostaglandin E stimulus; ISS:BHF-UCL.
DR GO; GO:0048144; P:fibroblast proliferation; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00068; GGL; 1.
DR Gene3D; 4.10.260.10; -; 1.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR001770; Gprotein-gamma.
DR PANTHER; PTHR13809; PTHR13809; 1.
DR Pfam; PF00631; G-gamma; 1.
DR PRINTS; PR00321; GPROTEING.
DR SMART; SM00224; GGL; 1.
DR SUPFAM; SSF48670; SSF48670; 1.
DR PROSITE; PS50058; G_PROTEIN_GAMMA; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cell membrane; Host-virus interaction;
KW Lipoprotein; Membrane; Methylation; Prenylation; Reference proteome;
KW Transducer.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:19413330,
FT ECO:0007744|PubMed:22814378"
FT CHAIN 2..68
FT /note="Guanine nucleotide-binding protein G(I)/G(S)/G(O)
FT subunit gamma-2"
FT /id="PRO_0000012611"
FT PROPEP 69..71
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000012612"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:19413330,
FT ECO:0007744|PubMed:22814378"
FT MOD_RES 68
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 68
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT HELIX 7..23
FT /evidence="ECO:0007829|PDB:7MBX"
FT HELIX 30..43
FT /evidence="ECO:0007829|PDB:7MBX"
FT HELIX 45..47
FT /evidence="ECO:0007829|PDB:7MBX"
FT TURN 49..51
FT /evidence="ECO:0007829|PDB:7MBX"
FT TURN 56..58
FT /evidence="ECO:0007829|PDB:7MBX"
FT HELIX 60..62
FT /evidence="ECO:0007829|PDB:6CRK"
FT TURN 63..66
FT /evidence="ECO:0007829|PDB:4KFM"
SQ SEQUENCE 71 AA; 7850 MW; EDB74E4135E7A37A CRC64;
MASNNTASIA QARKLVEQLK MEANIDRIKV SKAAADLMAY CEAHAKEDPL LTPVPASENP
FREKKFFCAI L
