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GBG4_MOUSE
ID   GBG4_MOUSE              Reviewed;          75 AA.
AC   P50153;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 166.
DE   RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4;
DE   Flags: Precursor;
GN   Name=Gng4; Synonyms=Gngt4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Brain;
RX   PubMed=7488078; DOI=10.1006/bbrc.1995.2600;
RA   Kalyanaraman S., Kalyanaraman V., Gautam N.;
RT   "A brain-specific G protein gamma subunit.";
RL   Biochem. Biophys. Res. Commun. 216:126-132(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9570961; DOI=10.1006/geno.1998.5223;
RA   Kalyanaraman S., Copeland N.G., Gilbert D.G., Jenkins N.A., Gautam N.;
RT   "Structure and chromosomal localization of mouse G protein subunit gamma4
RT   gene.";
RL   Genomics 49:147-151(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [5]
RP   INTERACTION WITH KCNK1.
RX   PubMed=24496152; DOI=10.1038/ncomms4227;
RA   Hwang E.M., Kim E., Yarishkin O., Woo D.H., Han K.S., Park N., Bae Y.,
RA   Woo J., Kim D., Park M., Lee C.J., Park J.Y.;
RT   "A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive
RT   conductance in astrocytes.";
RL   Nat. Commun. 5:3227-3227(2014).
CC   -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC       as a modulator or transducer in various transmembrane signaling
CC       systems. The beta and gamma chains are required for the GTPase
CC       activity, for replacement of GDP by GTP, and for G protein-effector
CC       interaction. {ECO:0000305}.
CC   -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma.
CC       Interacts with beta-1 and beta-2, but not with beta-3 (By similarity).
CC       Interacts with KCNK1. {ECO:0000250|UniProtKB:P50150,
CC       ECO:0000269|PubMed:24496152}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Brain. {ECO:0000269|PubMed:7488078}.
CC   -!- SIMILARITY: Belongs to the G protein gamma family. {ECO:0000305}.
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DR   EMBL; U37527; AAB93460.1; -; mRNA.
DR   EMBL; AF038594; AAC40090.1; -; Genomic_DNA.
DR   EMBL; AF038593; AAC40090.1; JOINED; Genomic_DNA.
DR   EMBL; BC016506; AAH16506.1; -; mRNA.
DR   CCDS; CCDS36598.1; -.
DR   PIR; JC4339; JC4339.
DR   RefSeq; NP_001289926.1; NM_001302997.1.
DR   RefSeq; NP_034447.1; NM_010317.3.
DR   AlphaFoldDB; P50153; -.
DR   SMR; P50153; -.
DR   BioGRID; 199990; 1.
DR   DIP; DIP-494N; -.
DR   IntAct; P50153; 1.
DR   STRING; 10090.ENSMUSP00000021734; -.
DR   iPTMnet; P50153; -.
DR   PhosphoSitePlus; P50153; -.
DR   MaxQB; P50153; -.
DR   PaxDb; P50153; -.
DR   PeptideAtlas; P50153; -.
DR   PRIDE; P50153; -.
DR   ProteomicsDB; 272936; -.
DR   Antibodypedia; 34696; 98 antibodies from 23 providers.
DR   DNASU; 14706; -.
DR   Ensembl; ENSMUST00000021734; ENSMUSP00000021734; ENSMUSG00000021303.
DR   GeneID; 14706; -.
DR   KEGG; mmu:14706; -.
DR   UCSC; uc007pml.2; mouse.
DR   CTD; 2786; -.
DR   MGI; MGI:102703; Gng4.
DR   VEuPathDB; HostDB:ENSMUSG00000021303; -.
DR   eggNOG; KOG4119; Eukaryota.
DR   GeneTree; ENSGT01050000244876; -.
DR   HOGENOM; CLU_168377_0_1_1; -.
DR   InParanoid; P50153; -.
DR   OMA; HMGEDPL; -.
DR   OrthoDB; 1581168at2759; -.
DR   PhylomeDB; P50153; -.
DR   TreeFam; TF319909; -.
DR   Reactome; R-MMU-1296041; Activation of G protein gated Potassium channels.
DR   Reactome; R-MMU-202040; G-protein activation.
DR   Reactome; R-MMU-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR   Reactome; R-MMU-392170; ADP signalling through P2Y purinoceptor 12.
DR   Reactome; R-MMU-392451; G beta:gamma signalling through PI3Kgamma.
DR   Reactome; R-MMU-392851; Prostacyclin signalling through prostacyclin receptor.
DR   Reactome; R-MMU-400042; Adrenaline,noradrenaline inhibits insulin secretion.
DR   Reactome; R-MMU-4086398; Ca2+ pathway.
DR   Reactome; R-MMU-416476; G alpha (q) signalling events.
DR   Reactome; R-MMU-416482; G alpha (12/13) signalling events.
DR   Reactome; R-MMU-418217; G beta:gamma signalling through PLC beta.
DR   Reactome; R-MMU-418555; G alpha (s) signalling events.
DR   Reactome; R-MMU-418592; ADP signalling through P2Y purinoceptor 1.
DR   Reactome; R-MMU-418594; G alpha (i) signalling events.
DR   Reactome; R-MMU-418597; G alpha (z) signalling events.
DR   Reactome; R-MMU-420092; Glucagon-type ligand receptors.
DR   Reactome; R-MMU-428930; Thromboxane signalling through TP receptor.
DR   Reactome; R-MMU-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR   Reactome; R-MMU-456926; Thrombin signalling through proteinase activated receptors (PARs).
DR   Reactome; R-MMU-500657; Presynaptic function of Kainate receptors.
DR   Reactome; R-MMU-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR   Reactome; R-MMU-8964315; G beta:gamma signalling through BTK.
DR   Reactome; R-MMU-8964616; G beta:gamma signalling through CDC42.
DR   Reactome; R-MMU-9009391; Extra-nuclear estrogen signaling.
DR   Reactome; R-MMU-9634597; GPER1 signaling.
DR   Reactome; R-MMU-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
DR   BioGRID-ORCS; 14706; 1 hit in 73 CRISPR screens.
DR   PRO; PR:P50153; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   RNAct; P50153; protein.
DR   Bgee; ENSMUSG00000021303; Expressed in facial nucleus and 156 other tissues.
DR   Genevisible; P50153; MM.
DR   GO; GO:0005834; C:heterotrimeric G-protein complex; ISA:MGI.
DR   GO; GO:0031681; F:G-protein beta-subunit binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; ISA:MGI.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR   GO; GO:0030308; P:negative regulation of cell growth; ISO:MGI.
DR   CDD; cd00068; GGL; 1.
DR   Gene3D; 4.10.260.10; -; 1.
DR   InterPro; IPR015898; G-protein_gamma-like_dom.
DR   InterPro; IPR036284; GGL_sf.
DR   InterPro; IPR001770; Gprotein-gamma.
DR   PANTHER; PTHR13809; PTHR13809; 1.
DR   Pfam; PF00631; G-gamma; 1.
DR   PRINTS; PR00321; GPROTEING.
DR   SMART; SM00224; GGL; 1.
DR   SUPFAM; SSF48670; SSF48670; 1.
DR   PROSITE; PS50058; G_PROTEIN_GAMMA; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Lipoprotein; Membrane; Methylation; Prenylation;
KW   Reference proteome; Transducer.
FT   CHAIN           1..72
FT                   /note="Guanine nucleotide-binding protein G(I)/G(S)/G(O)
FT                   subunit gamma-4"
FT                   /id="PRO_0000012623"
FT   PROPEP          73..75
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000012624"
FT   MOD_RES         72
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250"
FT   LIPID           72
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   75 AA;  8405 MW;  42FAEF47311FA195 CRC64;
     MKEGMSNNST TSISQARKAV EQLKMEACMD RVKVSQAASD LLAYCEAHVR EDPLIIPVPA
     SENPFREKKF FCTIL
 
 
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