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GBG5_MOUSE
ID   GBG5_MOUSE              Reviewed;          68 AA.
AC   Q80SZ7; P30670; Q5I0W4; Q61015;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2004, sequence version 2.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5;
DE   Flags: Precursor;
GN   Name=Gng5; Synonyms=Gngt5;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Brain, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 8-53.
RC   STRAIN=CF-1 / Harlan;
RX   PubMed=8858601;
RX   DOI=10.1002/(sici)1098-2795(199607)44:3<315::aid-mrd5>3.0.co;2-p;
RA   Williams C.J., Schultz R.M., Kopf G.S.;
RT   "G protein gene expression during mouse oocyte growth and maturation, and
RT   preimplantation embryo development.";
RL   Mol. Reprod. Dev. 44:315-323(1996).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Kidney, Lung, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC       as a modulator or transducer in various transmembrane signaling
CC       systems. The beta and gamma chains are required for the GTPase
CC       activity, for replacement of GDP by GTP, and for G protein-effector
CC       interaction.
CC   -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G protein gamma family. {ECO:0000305}.
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DR   EMBL; BC002316; AAH02316.3; -; mRNA.
DR   EMBL; BC087872; AAH87872.1; -; mRNA.
DR   EMBL; U38498; AAB01729.1; -; mRNA.
DR   CCDS; CCDS17903.1; -.
DR   RefSeq; NP_034448.2; NM_010318.2.
DR   RefSeq; XP_003945606.1; XM_003945557.2.
DR   AlphaFoldDB; Q80SZ7; -.
DR   SMR; Q80SZ7; -.
DR   BioGRID; 199991; 3.
DR   IntAct; Q80SZ7; 1.
DR   STRING; 10090.ENSMUSP00000087485; -.
DR   iPTMnet; Q80SZ7; -.
DR   PhosphoSitePlus; Q80SZ7; -.
DR   EPD; Q80SZ7; -.
DR   jPOST; Q80SZ7; -.
DR   MaxQB; Q80SZ7; -.
DR   PaxDb; Q80SZ7; -.
DR   PRIDE; Q80SZ7; -.
DR   ProteomicsDB; 266777; -.
DR   DNASU; 14707; -.
DR   Ensembl; ENSMUST00000090031; ENSMUSP00000087485; ENSMUSG00000068523.
DR   Ensembl; ENSMUST00000118280; ENSMUSP00000114014; ENSMUSG00000068523.
DR   GeneID; 14707; -.
DR   KEGG; mmu:14707; -.
DR   UCSC; uc008rrk.1; mouse.
DR   CTD; 2787; -.
DR   MGI; MGI:109164; Gng5.
DR   VEuPathDB; HostDB:ENSMUSG00000068523; -.
DR   eggNOG; KOG4119; Eukaryota.
DR   GeneTree; ENSGT01050000244858; -.
DR   HOGENOM; CLU_168377_3_0_1; -.
DR   InParanoid; Q80SZ7; -.
DR   OMA; QNALHDP; -.
DR   OrthoDB; 1581168at2759; -.
DR   PhylomeDB; Q80SZ7; -.
DR   TreeFam; TF319909; -.
DR   Reactome; R-MMU-1296041; Activation of G protein gated Potassium channels.
DR   Reactome; R-MMU-202040; G-protein activation.
DR   Reactome; R-MMU-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR   Reactome; R-MMU-392170; ADP signalling through P2Y purinoceptor 12.
DR   Reactome; R-MMU-392451; G beta:gamma signalling through PI3Kgamma.
DR   Reactome; R-MMU-392851; Prostacyclin signalling through prostacyclin receptor.
DR   Reactome; R-MMU-400042; Adrenaline,noradrenaline inhibits insulin secretion.
DR   Reactome; R-MMU-4086398; Ca2+ pathway.
DR   Reactome; R-MMU-416476; G alpha (q) signalling events.
DR   Reactome; R-MMU-416482; G alpha (12/13) signalling events.
DR   Reactome; R-MMU-418217; G beta:gamma signalling through PLC beta.
DR   Reactome; R-MMU-418555; G alpha (s) signalling events.
DR   Reactome; R-MMU-418592; ADP signalling through P2Y purinoceptor 1.
DR   Reactome; R-MMU-418594; G alpha (i) signalling events.
DR   Reactome; R-MMU-418597; G alpha (z) signalling events.
DR   Reactome; R-MMU-420092; Glucagon-type ligand receptors.
DR   Reactome; R-MMU-428930; Thromboxane signalling through TP receptor.
DR   Reactome; R-MMU-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR   Reactome; R-MMU-456926; Thrombin signalling through proteinase activated receptors (PARs).
DR   Reactome; R-MMU-500657; Presynaptic function of Kainate receptors.
DR   Reactome; R-MMU-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR   Reactome; R-MMU-8964315; G beta:gamma signalling through BTK.
DR   Reactome; R-MMU-8964616; G beta:gamma signalling through CDC42.
DR   Reactome; R-MMU-9009391; Extra-nuclear estrogen signaling.
DR   Reactome; R-MMU-9634597; GPER1 signaling.
DR   Reactome; R-MMU-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
DR   BioGRID-ORCS; 14707; 10 hits in 67 CRISPR screens.
DR   ChiTaRS; Gng5; mouse.
DR   PRO; PR:Q80SZ7; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; Q80SZ7; protein.
DR   Bgee; ENSMUSG00000068523; Expressed in right kidney and 117 other tissues.
DR   ExpressionAtlas; Q80SZ7; baseline and differential.
DR   Genevisible; Q80SZ7; MM.
DR   GO; GO:0031680; C:G-protein beta/gamma-subunit complex; ISO:MGI.
DR   GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0031681; F:G-protein beta-subunit binding; IBA:GO_Central.
DR   GO; GO:0030165; F:PDZ domain binding; ISO:MGI.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:2000179; P:positive regulation of neural precursor cell proliferation; IMP:MGI.
DR   GO; GO:0072513; P:positive regulation of secondary heart field cardioblast proliferation; IMP:MGI.
DR   CDD; cd00068; GGL; 1.
DR   Gene3D; 4.10.260.10; -; 1.
DR   InterPro; IPR015898; G-protein_gamma-like_dom.
DR   InterPro; IPR036284; GGL_sf.
DR   InterPro; IPR001770; Gprotein-gamma.
DR   PANTHER; PTHR13809; PTHR13809; 1.
DR   Pfam; PF00631; G-gamma; 1.
DR   PRINTS; PR00321; GPROTEING.
DR   SMART; SM00224; GGL; 1.
DR   SUPFAM; SSF48670; SSF48670; 1.
DR   PROSITE; PS50058; G_PROTEIN_GAMMA; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cell membrane; Lipoprotein; Membrane; Methylation;
KW   Phosphoprotein; Prenylation; Reference proteome; Transducer.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P63218"
FT   CHAIN           2..65
FT                   /note="Guanine nucleotide-binding protein G(I)/G(S)/G(O)
FT                   subunit gamma-5"
FT                   /id="PRO_0000012629"
FT   PROPEP          66..68
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000012630"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:P63218"
FT   MOD_RES         2
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P63218"
FT   MOD_RES         65
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250"
FT   LIPID           65
FT                   /note="S-geranylgeranyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   68 AA;  7318 MW;  9AF7A16558863602 CRC64;
     MSGSSSVAAM KKVVQQLRLE AGLNRVKVSQ AAADLKQFCL QNAQHDPLLT GVSSSTNPFR
     PQKVCSFL
 
 
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