ID   ALLA4_DELRA             Reviewed;           8 AA.
AC   B3EWL8;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   02-JUN-2021, entry version 9.
DE   RecName: Full=Allatostatin-A4;
DE            Short=AST-A4;
DE   AltName: Full=LPVYNFGL-amide {ECO:0000303|PubMed:20869420, ECO:0000303|PubMed:22848525};
OS   Delia radicum (Cabbage root fly) (Anthomyia brassicae).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Anthomyiidae; Anthomyiinae; Delia.
OX   NCBI_TaxID=30064;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, TISSUE SPECIFICITY, MASS SPECTROMETRY, AND AMIDATION AT
RP   LEU-8.
RC   TISSUE=Abdominal ganglion {ECO:0000269|PubMed:20869420}, and
RC   Brain {ECO:0000269|PubMed:20869420};
RX   PubMed=20869420; DOI=10.1016/j.peptides.2010.08.028;
RA   Audsley N., Matthews H.J., Down R.E., Weaver R.J.;
RT   "Neuropeptides associated with the central nervous system of the cabbage
RT   root fly, Delia radicum (L).";
RL   Peptides 32:434-440(2011).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Midgut {ECO:0000269|PubMed:22848525};
RX   PubMed=22848525; DOI=10.1371/journal.pone.0041543;
RA   Zoephel J., Reiher W., Rexer K.-H., Kahnt J., Wegener C.;
RT   "Peptidomics of the agriculturally damaging larval stage of the cabbage
RT   root fly Delia radicum (Diptera: Anthomyiidae).";
RL   PLoS ONE 7:E41543-E41543(2012).
CC   -!- FUNCTION: May act as a neurotransmitter or neuromodulator.
CC       {ECO:0000250|UniProtKB:P42559}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P42559}.
CC   -!- TISSUE SPECIFICITY: In larvae, detected in midgut but not in the CNS,
CC       ring gland, abdominal perisympathetic organs (aPSO) or thoracic
CC       perisympathetic organs (tPSO) (at protein level). In adults, expressed
CC       in brain, and thoracic-abdominal ganglion but not in corpora cardiaca
CC       and corpora allata (at protein level). {ECO:0000269|PubMed:20869420,
CC       ECO:0000269|PubMed:22848525}.
CC   -!- DEVELOPMENTAL STAGE: Detected in larvae and adults.
CC       {ECO:0000269|PubMed:20869420, ECO:0000269|PubMed:22848525}.
CC   -!- MASS SPECTROMETRY: Mass=921.5; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:20869420, ECO:0000269|PubMed:22848525};
CC   -!- MASS SPECTROMETRY: Mass=921.43; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:20869420, ECO:0000269|PubMed:22848525};
CC   -!- SIMILARITY: Belongs to the allatostatin family. {ECO:0000255}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT   PEPTIDE         1..8
FT                   /note="Allatostatin-A4"
FT                   /id="PRO_0000419714"
FT   MOD_RES         8
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000269|PubMed:20869420"
SQ   SEQUENCE   8 AA;  922 MW;  0B2879C45B42D767 CRC64;
     LPVYNFGL