GBG8_HUMAN
ID GBG8_HUMAN Reviewed; 70 AA.
AC Q9UK08; Q4VBM5;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8;
DE AltName: Full=Gamma-9;
DE Flags: Precursor;
GN Name=GNG8; Synonyms=GNG9, GNGT9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10819326; DOI=10.1093/dnares/7.2.111;
RA Hurowitz E.H., Melnyk J.M., Chen Y.J., Kouros-Mehr H., Simon M.I.,
RA Shizuya H.;
RT "Genomic characterization of the human heterotrimeric G protein alpha,
RT beta, and gamma subunit genes.";
RL DNA Res. 7:111-120(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC as a modulator or transducer in various transmembrane signaling
CC systems. The beta and gamma chains are required for the GTPase
CC activity, for replacement of GDP by GTP, and for G protein-effector
CC interaction.
CC -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma.
CC -!- INTERACTION:
CC Q9UK08; P32302: CXCR5; NbExp=3; IntAct=EBI-9074207, EBI-2835269;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G protein gamma family. {ECO:0000305}.
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DR EMBL; AF188179; AAF04569.1; -; Genomic_DNA.
DR EMBL; AF493875; AAM12589.1; -; mRNA.
DR EMBL; BC095514; AAH95514.1; -; mRNA.
DR CCDS; CCDS12687.1; -.
DR RefSeq; NP_150283.1; NM_033258.1.
DR RefSeq; XP_016882992.1; XM_017027503.1.
DR RefSeq; XP_016882993.1; XM_017027504.1.
DR RefSeq; XP_016882994.1; XM_017027505.1.
DR AlphaFoldDB; Q9UK08; -.
DR SMR; Q9UK08; -.
DR BioGRID; 125148; 132.
DR CORUM; Q9UK08; -.
DR IntAct; Q9UK08; 1.
DR STRING; 9606.ENSP00000300873; -.
DR BioMuta; GNG8; -.
DR DMDM; 12232629; -.
DR MassIVE; Q9UK08; -.
DR PaxDb; Q9UK08; -.
DR PeptideAtlas; Q9UK08; -.
DR PRIDE; Q9UK08; -.
DR ProteomicsDB; 84700; -.
DR TopDownProteomics; Q9UK08; -.
DR Antibodypedia; 31465; 49 antibodies from 13 providers.
DR DNASU; 94235; -.
DR Ensembl; ENST00000300873.5; ENSP00000300873.3; ENSG00000167414.5.
DR Ensembl; ENST00000693335.1; ENSP00000508424.1; ENSG00000167414.5.
DR GeneID; 94235; -.
DR KEGG; hsa:94235; -.
DR MANE-Select; ENST00000693335.1; ENSP00000508424.1; NM_033258.2; NP_150283.1.
DR UCSC; uc010xyd.3; human.
DR CTD; 94235; -.
DR DisGeNET; 94235; -.
DR GeneCards; GNG8; -.
DR HGNC; HGNC:19664; GNG8.
DR HPA; ENSG00000167414; Tissue enhanced (brain, choroid plexus).
DR neXtProt; NX_Q9UK08; -.
DR OpenTargets; ENSG00000167414; -.
DR PharmGKB; PA134921496; -.
DR VEuPathDB; HostDB:ENSG00000167414; -.
DR eggNOG; KOG4119; Eukaryota.
DR GeneTree; ENSGT01050000244876; -.
DR HOGENOM; CLU_168377_0_1_1; -.
DR InParanoid; Q9UK08; -.
DR OMA; LMSYCES; -.
DR OrthoDB; 1581168at2759; -.
DR PhylomeDB; Q9UK08; -.
DR TreeFam; TF319909; -.
DR PathwayCommons; Q9UK08; -.
DR Reactome; R-HSA-1296041; Activation of G protein gated Potassium channels.
DR Reactome; R-HSA-163359; Glucagon signaling in metabolic regulation.
DR Reactome; R-HSA-202040; G-protein activation.
DR Reactome; R-HSA-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR Reactome; R-HSA-392170; ADP signalling through P2Y purinoceptor 12.
DR Reactome; R-HSA-392451; G beta:gamma signalling through PI3Kgamma.
DR Reactome; R-HSA-392851; Prostacyclin signalling through prostacyclin receptor.
DR Reactome; R-HSA-400042; Adrenaline,noradrenaline inhibits insulin secretion.
DR Reactome; R-HSA-4086398; Ca2+ pathway.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR Reactome; R-HSA-416482; G alpha (12/13) signalling events.
DR Reactome; R-HSA-418217; G beta:gamma signalling through PLC beta.
DR Reactome; R-HSA-418555; G alpha (s) signalling events.
DR Reactome; R-HSA-418592; ADP signalling through P2Y purinoceptor 1.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR Reactome; R-HSA-418597; G alpha (z) signalling events.
DR Reactome; R-HSA-420092; Glucagon-type ligand receptors.
DR Reactome; R-HSA-428930; Thromboxane signalling through TP receptor.
DR Reactome; R-HSA-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR Reactome; R-HSA-456926; Thrombin signalling through proteinase activated receptors (PARs).
DR Reactome; R-HSA-500657; Presynaptic function of Kainate receptors.
DR Reactome; R-HSA-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR Reactome; R-HSA-8964315; G beta:gamma signalling through BTK.
DR Reactome; R-HSA-8964616; G beta:gamma signalling through CDC42.
DR Reactome; R-HSA-9009391; Extra-nuclear estrogen signaling.
DR Reactome; R-HSA-9634597; GPER1 signaling.
DR Reactome; R-HSA-9660821; ADORA2B mediated anti-inflammatory cytokines production.
DR Reactome; R-HSA-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
DR SignaLink; Q9UK08; -.
DR BioGRID-ORCS; 94235; 12 hits in 1064 CRISPR screens.
DR GenomeRNAi; 94235; -.
DR Pharos; Q9UK08; Tdark.
DR PRO; PR:Q9UK08; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9UK08; protein.
DR Bgee; ENSG00000167414; Expressed in apex of heart and 94 other tissues.
DR Genevisible; Q9UK08; HS.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0031681; F:G-protein beta-subunit binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; NAS:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00068; GGL; 1.
DR Gene3D; 4.10.260.10; -; 1.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR001770; Gprotein-gamma.
DR PANTHER; PTHR13809; PTHR13809; 1.
DR Pfam; PF00631; G-gamma; 1.
DR PRINTS; PR00321; GPROTEING.
DR SMART; SM00224; GGL; 1.
DR SUPFAM; SSF48670; SSF48670; 1.
DR PROSITE; PS50058; G_PROTEIN_GAMMA; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Lipoprotein; Membrane; Methylation; Prenylation;
KW Reference proteome; Transducer.
FT CHAIN 1..67
FT /note="Guanine nucleotide-binding protein G(I)/G(S)/G(O)
FT subunit gamma-8"
FT /id="PRO_0000012649"
FT PROPEP 68..70
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000012650"
FT MOD_RES 67
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 67
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 70 AA; 7841 MW; 153205CC7F38EE40 CRC64;
MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV TPVPAAENPF
RDKRLFCVLL
