GBG8_MOUSE
ID GBG8_MOUSE Reviewed; 70 AA.
AC P63078; P43426;
DT 13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8;
DE AltName: Full=Gamma-9;
DE Flags: Precursor;
GN Name=Gng8; Synonyms=Gng9, Gngt9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10819326; DOI=10.1093/dnares/7.2.111;
RA Hurowitz E.H., Melnyk J.M., Chen Y.J., Kouros-Mehr H., Simon M.I.,
RA Shizuya H.;
RT "Genomic characterization of the human heterotrimeric G protein alpha,
RT beta, and gamma subunit genes.";
RL DNA Res. 7:111-120(2000).
CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC as a modulator or transducer in various transmembrane signaling
CC systems. The beta and gamma chains are required for the GTPase
CC activity, for replacement of GDP by GTP, and for G protein-effector
CC interaction. This subunit may have a very specific role in the
CC development and turnover of olfactory and vomeronasal neurons.
CC -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G protein gamma family. {ECO:0000305}.
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DR EMBL; AF188180; AAF04570.1; -; Genomic_DNA.
DR CCDS; CCDS20856.1; -.
DR RefSeq; NP_034450.1; NM_010320.3.
DR RefSeq; XP_006539610.1; XM_006539547.3.
DR RefSeq; XP_006539611.1; XM_006539548.1.
DR RefSeq; XP_006539612.1; XM_006539549.3.
DR RefSeq; XP_011248738.1; XM_011250436.2.
DR AlphaFoldDB; P63078; -.
DR SMR; P63078; -.
DR BioGRID; 199993; 1.
DR IntAct; P63078; 1.
DR STRING; 10090.ENSMUSP00000077314; -.
DR PaxDb; P63078; -.
DR PRIDE; P63078; -.
DR ProteomicsDB; 273419; -.
DR Antibodypedia; 31465; 49 antibodies from 13 providers.
DR DNASU; 14709; -.
DR Ensembl; ENSMUST00000078182; ENSMUSP00000077314; ENSMUSG00000063594.
DR Ensembl; ENSMUST00000205459; ENSMUSP00000145533; ENSMUSG00000063594.
DR Ensembl; ENSMUST00000205716; ENSMUSP00000145567; ENSMUSG00000063594.
DR GeneID; 14709; -.
DR KEGG; mmu:14709; -.
DR UCSC; uc009fik.1; mouse.
DR CTD; 94235; -.
DR MGI; MGI:109163; Gng8.
DR VEuPathDB; HostDB:ENSMUSG00000063594; -.
DR eggNOG; KOG4119; Eukaryota.
DR GeneTree; ENSGT01050000244876; -.
DR HOGENOM; CLU_168377_0_1_1; -.
DR InParanoid; P63078; -.
DR OMA; LMSYCES; -.
DR OrthoDB; 1581168at2759; -.
DR PhylomeDB; P63078; -.
DR TreeFam; TF319909; -.
DR Reactome; R-MMU-1296041; Activation of G protein gated Potassium channels.
DR Reactome; R-MMU-202040; G-protein activation.
DR Reactome; R-MMU-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR Reactome; R-MMU-392170; ADP signalling through P2Y purinoceptor 12.
DR Reactome; R-MMU-392451; G beta:gamma signalling through PI3Kgamma.
DR Reactome; R-MMU-392851; Prostacyclin signalling through prostacyclin receptor.
DR Reactome; R-MMU-400042; Adrenaline,noradrenaline inhibits insulin secretion.
DR Reactome; R-MMU-4086398; Ca2+ pathway.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR Reactome; R-MMU-416482; G alpha (12/13) signalling events.
DR Reactome; R-MMU-418217; G beta:gamma signalling through PLC beta.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR Reactome; R-MMU-418592; ADP signalling through P2Y purinoceptor 1.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR Reactome; R-MMU-418597; G alpha (z) signalling events.
DR Reactome; R-MMU-420092; Glucagon-type ligand receptors.
DR Reactome; R-MMU-428930; Thromboxane signalling through TP receptor.
DR Reactome; R-MMU-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR Reactome; R-MMU-456926; Thrombin signalling through proteinase activated receptors (PARs).
DR Reactome; R-MMU-500657; Presynaptic function of Kainate receptors.
DR Reactome; R-MMU-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR Reactome; R-MMU-8964315; G beta:gamma signalling through BTK.
DR Reactome; R-MMU-8964616; G beta:gamma signalling through CDC42.
DR Reactome; R-MMU-9009391; Extra-nuclear estrogen signaling.
DR Reactome; R-MMU-9634597; GPER1 signaling.
DR Reactome; R-MMU-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
DR BioGRID-ORCS; 14709; 0 hits in 68 CRISPR screens.
DR PRO; PR:P63078; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P63078; protein.
DR Bgee; ENSMUSG00000063594; Expressed in habenula and 69 other tissues.
DR ExpressionAtlas; P63078; baseline and differential.
DR Genevisible; P63078; MM.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR GO; GO:0031681; F:G-protein beta-subunit binding; IBA:GO_Central.
DR GO; GO:0071444; P:cellular response to pheromone; IMP:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0043584; P:nose development; IMP:MGI.
DR GO; GO:0035176; P:social behavior; IMP:MGI.
DR CDD; cd00068; GGL; 1.
DR Gene3D; 4.10.260.10; -; 1.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR001770; Gprotein-gamma.
DR PANTHER; PTHR13809; PTHR13809; 1.
DR Pfam; PF00631; G-gamma; 1.
DR PRINTS; PR00321; GPROTEING.
DR SMART; SM00224; GGL; 1.
DR SUPFAM; SSF48670; SSF48670; 1.
DR PROSITE; PS50058; G_PROTEIN_GAMMA; 1.
PE 3: Inferred from homology;
KW Cell membrane; Lipoprotein; Membrane; Methylation; Prenylation;
KW Reference proteome; Transducer.
FT CHAIN 1..67
FT /note="Guanine nucleotide-binding protein G(I)/G(S)/G(O)
FT subunit gamma-8"
FT /id="PRO_0000012651"
FT PROPEP 68..70
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000012652"
FT MOD_RES 67
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 67
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 70 AA; 7843 MW; 153206AC7F38EE40 CRC64;
MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV TPVPAAENPF
RDKRLFCTLL
