GBG8_RAT
ID GBG8_RAT Reviewed; 70 AA.
AC P63077; P43426;
DT 13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8;
DE AltName: Full=Gamma-9;
DE Flags: Precursor;
GN Name=Gng8; Synonyms=Gng9, Gngt9;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=Wistar; TISSUE=Olfactory epithelium;
RX PubMed=7896821; DOI=10.1074/jbc.270.12.6757;
RA Ryba N.J.P., Tirindelli R.;
RT "A novel GTP-binding protein gamma-subunit, G gamma 8, is expressed during
RT neurogenesis in the olfactory and vomeronasal neuroepithelia.";
RL J. Biol. Chem. 270:6757-6767(1995).
CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC as a modulator or transducer in various transmembrane signaling
CC systems. The beta and gamma chains are required for the GTPase
CC activity, for replacement of GDP by GTP, and for G protein-effector
CC interaction. This subunit may have a very specific role in the
CC development and turnover of olfactory and vomeronasal neurons.
CC {ECO:0000269|PubMed:7896821}.
CC -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Detected in the olfactory epithelium, the
CC vomeronasal epithelium and, to a lesser extent, the olfactory bulb.
CC {ECO:0000269|PubMed:7896821}.
CC -!- DEVELOPMENTAL STAGE: During development, expression in the olfactory
CC epithelium parallels neurogenesis, peaking shortly after birth and
CC declining in the adult. {ECO:0000269|PubMed:7896821}.
CC -!- SIMILARITY: Belongs to the G protein gamma family. {ECO:0000305}.
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DR EMBL; L35921; AAA73553.1; -; mRNA.
DR PIR; A56181; A56181.
DR RefSeq; NP_631924.1; NM_139185.1.
DR RefSeq; XP_006228446.1; XM_006228384.3.
DR RefSeq; XP_006228447.1; XM_006228385.3.
DR AlphaFoldDB; P63077; -.
DR SMR; P63077; -.
DR STRING; 10116.ENSRNOP00000022441; -.
DR PaxDb; P63077; -.
DR PRIDE; P63077; -.
DR Ensembl; ENSRNOT00000090417; ENSRNOP00000072099; ENSRNOG00000016701.
DR GeneID; 245986; -.
DR KEGG; rno:245986; -.
DR UCSC; RGD:620808; rat.
DR CTD; 94235; -.
DR RGD; 620808; Gng8.
DR eggNOG; KOG4119; Eukaryota.
DR GeneTree; ENSGT01050000244876; -.
DR InParanoid; P63077; -.
DR OMA; LMSYCES; -.
DR OrthoDB; 1581168at2759; -.
DR PhylomeDB; P63077; -.
DR TreeFam; TF319909; -.
DR Reactome; R-RNO-1296041; Activation of G protein gated Potassium channels.
DR Reactome; R-RNO-202040; G-protein activation.
DR Reactome; R-RNO-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR Reactome; R-RNO-392170; ADP signalling through P2Y purinoceptor 12.
DR Reactome; R-RNO-392451; G beta:gamma signalling through PI3Kgamma.
DR Reactome; R-RNO-400042; Adrenaline,noradrenaline inhibits insulin secretion.
DR Reactome; R-RNO-4086398; Ca2+ pathway.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR Reactome; R-RNO-418594; G alpha (i) signalling events.
DR Reactome; R-RNO-418597; G alpha (z) signalling events.
DR Reactome; R-RNO-420092; Glucagon-type ligand receptors.
DR Reactome; R-RNO-428930; Thromboxane signalling through TP receptor.
DR Reactome; R-RNO-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR Reactome; R-RNO-456926; Thrombin signalling through proteinase activated receptors (PARs).
DR Reactome; R-RNO-8964616; G beta:gamma signalling through CDC42.
DR Reactome; R-RNO-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
DR PRO; PR:P63077; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000016701; Expressed in lung and 20 other tissues.
DR Genevisible; P63077; RN.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR GO; GO:0031681; F:G-protein beta-subunit binding; IBA:GO_Central.
DR GO; GO:0071444; P:cellular response to pheromone; ISO:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IEP:RGD.
DR GO; GO:0043584; P:nose development; ISO:RGD.
DR GO; GO:0035176; P:social behavior; ISO:RGD.
DR CDD; cd00068; GGL; 1.
DR Gene3D; 4.10.260.10; -; 1.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR001770; Gprotein-gamma.
DR PANTHER; PTHR13809; PTHR13809; 1.
DR Pfam; PF00631; G-gamma; 1.
DR PRINTS; PR00321; GPROTEING.
DR SMART; SM00224; GGL; 1.
DR SUPFAM; SSF48670; SSF48670; 1.
DR PROSITE; PS50058; G_PROTEIN_GAMMA; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Lipoprotein; Membrane; Methylation; Prenylation;
KW Reference proteome; Transducer.
FT CHAIN 1..67
FT /note="Guanine nucleotide-binding protein G(I)/G(S)/G(O)
FT subunit gamma-8"
FT /id="PRO_0000012653"
FT PROPEP 68..70
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000012654"
FT MOD_RES 67
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 67
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 70 AA; 7843 MW; 153206AC7F38EE40 CRC64;
MSNNMAKIAE ARKTVEQLKL EVNIDRMKVS QAAAELLAFC ETHAKDDPLV TPVPAAENPF
RDKRLFCTLL
