GBG_CAEEL
ID GBG_CAEEL Reviewed; 62 AA.
AC P54406;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Guanine nucleotide-binding protein subunit gamma;
DE Flags: Precursor;
GN Name=gpc-1; ORFNames=K02A4.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH GPB-1 AND GPB-2.
RC STRAIN=Bristol N2;
RX PubMed=11333232; DOI=10.1093/genetics/158.1.221;
RA van Der Linden A.M., Simmer F., Cuppen E., Plasterk R.H.A.;
RT "The G protein beta subunit gpb-2 in Caenorhabditis elegans regulates the
RT G(o)alpha-G(q)alpha signaling network through interactions with the
RT regulator of G protein signaling proteins egl-10 and eat-16.";
RL Genetics 158:221-235(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC as a modulator or transducer in various transmembrane signaling
CC systems. The beta and gamma chains are required for the GTPase
CC activity, for replacement of GDP by GTP, and for G protein-effector
CC interaction.
CC -!- SUBUNIT: G proteins are composed of 3 units, alpha, beta and gamma (By
CC similarity). Interacts with gpb-1 and gpb-2 (PubMed:11333232).
CC {ECO:0000250|UniProtKB:P63212, ECO:0000269|PubMed:11333232}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in the central nervous
CC system.
CC -!- SIMILARITY: Belongs to the G protein gamma family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF291848; AAK55965.1; -; mRNA.
DR EMBL; Z67883; CAA91806.1; -; Genomic_DNA.
DR PIR; T23216; T23216.
DR RefSeq; NP_510145.1; NM_077744.4.
DR AlphaFoldDB; P54406; -.
DR SMR; P54406; -.
DR BioGRID; 46328; 3.
DR DIP; DIP-27168N; -.
DR STRING; 6239.K02A4.2.2; -.
DR PaxDb; P54406; -.
DR EnsemblMetazoa; K02A4.2.1; K02A4.2.1; WBGene00001681.
DR EnsemblMetazoa; K02A4.2.2; K02A4.2.2; WBGene00001681.
DR EnsemblMetazoa; K02A4.2.3; K02A4.2.3; WBGene00001681.
DR GeneID; 181424; -.
DR UCSC; K02A4.2.2; c. elegans.
DR CTD; 181424; -.
DR WormBase; K02A4.2; CE03458; WBGene00001681; gpc-1.
DR eggNOG; KOG4119; Eukaryota.
DR HOGENOM; CLU_168377_3_1_1; -.
DR InParanoid; P54406; -.
DR OMA; MDIMASN; -.
DR OrthoDB; 1581168at2759; -.
DR PhylomeDB; P54406; -.
DR Reactome; R-CEL-1296041; Activation of G protein gated Potassium channels.
DR Reactome; R-CEL-202040; G-protein activation.
DR Reactome; R-CEL-2485179; Activation of the phototransduction cascade.
DR Reactome; R-CEL-2514859; Inactivation, recovery and regulation of the phototransduction cascade.
DR Reactome; R-CEL-392170; ADP signalling through P2Y purinoceptor 12.
DR Reactome; R-CEL-392451; G beta:gamma signalling through PI3Kgamma.
DR Reactome; R-CEL-400042; Adrenaline,noradrenaline inhibits insulin secretion.
DR Reactome; R-CEL-4086398; Ca2+ pathway.
DR Reactome; R-CEL-416476; G alpha (q) signalling events.
DR Reactome; R-CEL-416482; G alpha (12/13) signalling events.
DR Reactome; R-CEL-418555; G alpha (s) signalling events.
DR Reactome; R-CEL-418594; G alpha (i) signalling events.
DR Reactome; R-CEL-418597; G alpha (z) signalling events.
DR Reactome; R-CEL-428930; Thromboxane signalling through TP receptor.
DR Reactome; R-CEL-456926; Thrombin signalling through proteinase activated receptors (PARs).
DR Reactome; R-CEL-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR Reactome; R-CEL-8964616; G beta:gamma signalling through CDC42.
DR Reactome; R-CEL-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
DR PRO; PR:P54406; -.
DR Proteomes; UP000001940; Chromosome X.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; ISS:WormBase.
DR GO; GO:0031681; F:G-protein beta-subunit binding; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:WormBase.
DR GO; GO:0050909; P:sensory perception of taste; IMP:WormBase.
DR CDD; cd00068; GGL; 1.
DR Gene3D; 4.10.260.10; -; 1.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR001770; Gprotein-gamma.
DR PANTHER; PTHR13809; PTHR13809; 1.
DR Pfam; PF00631; G-gamma; 1.
DR PRINTS; PR00321; GPROTEING.
DR SMART; SM00224; GGL; 1.
DR SUPFAM; SSF48670; SSF48670; 1.
DR PROSITE; PS50058; G_PROTEIN_GAMMA; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Lipoprotein; Membrane; Methylation; Prenylation;
KW Reference proteome; Transducer.
FT CHAIN 1..59
FT /note="Guanine nucleotide-binding protein subunit gamma"
FT /id="PRO_0000012675"
FT PROPEP 60..62
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000012676"
FT REGION 40..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 59
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 59
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 62 AA; 7014 MW; A85D06EAD34D52C4 CRC64;
MENIKASTEQ LCAEANIQRK KVSEVSKELL DFCEKNKTND MLVSGPTDQH NPFQEKKSCS
VL
