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GBLP_CAEEL
ID   GBLP_CAEEL              Reviewed;         325 AA.
AC   Q21215;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 160.
DE   RecName: Full=Guanine nucleotide-binding protein subunit beta-2-like 1;
GN   Name=rack-1; ORFNames=K04D7.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-14.
RC   STRAIN=Bristol N2;
RX   PubMed=9150941; DOI=10.1002/elps.1150180337;
RA   Bini L., Heid H., Liberatori S., Geier G., Pallini V., Zwilling R.;
RT   "Two-dimensional gel electrophoresis of Caenorhabditis elegans homogenates
RT   and identification of protein spots by microsequencing.";
RL   Electrophoresis 18:557-562(1997).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=19380113; DOI=10.1016/j.chom.2009.03.006;
RA   Ziegler K., Kurz C.L., Cypowyj S., Couillault C., Pophillat M., Pujol N.,
RA   Ewbank J.J.;
RT   "Antifungal innate immunity in C. elegans: PKCdelta links G protein
RT   signaling and a conserved p38 MAPK cascade.";
RL   Cell Host Microbe 5:341-352(2009).
CC   -!- FUNCTION: Required for the expression of antimicrobial peptide nlp-29
CC       in response to fungal infection or physical injury.
CC       {ECO:0000269|PubMed:19380113}.
CC   -!- INTERACTION:
CC       Q21215; G5EBY5: sipa-1; NbExp=2; IntAct=EBI-315497, EBI-314833;
CC       Q21215; Q95QM5: unc-115; NbExp=2; IntAct=EBI-315497, EBI-4405677;
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown causes a complete loss of
CC       nlp-29 expression following fungal infection by D.coniospora and a
CC       partial reduction following physical injury.
CC       {ECO:0000269|PubMed:19380113}.
CC   -!- SIMILARITY: Belongs to the WD repeat G protein beta family. Ribosomal
CC       protein RACK1 subfamily. {ECO:0000305}.
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DR   EMBL; Z69664; CAA93514.1; -; Genomic_DNA.
DR   PIR; T23309; T23309.
DR   RefSeq; NP_501859.1; NM_069458.4.
DR   AlphaFoldDB; Q21215; -.
DR   SMR; Q21215; -.
DR   BioGRID; 42997; 58.
DR   DIP; DIP-26516N; -.
DR   IntAct; Q21215; 6.
DR   MINT; Q21215; -.
DR   STRING; 6239.K04D7.1.3; -.
DR   iPTMnet; Q21215; -.
DR   World-2DPAGE; 0020:Q21215; -.
DR   EPD; Q21215; -.
DR   PaxDb; Q21215; -.
DR   PeptideAtlas; Q21215; -.
DR   EnsemblMetazoa; K04D7.1.1; K04D7.1.1; WBGene00010556.
DR   EnsemblMetazoa; K04D7.1.2; K04D7.1.2; WBGene00010556.
DR   EnsemblMetazoa; K04D7.1.3; K04D7.1.3; WBGene00010556.
DR   GeneID; 177895; -.
DR   KEGG; cel:CELE_K04D7.1; -.
DR   UCSC; K04D7.1.1; c. elegans.
DR   CTD; 177895; -.
DR   WormBase; K04D7.1; CE06090; WBGene00010556; rack-1.
DR   eggNOG; KOG0279; Eukaryota.
DR   GeneTree; ENSGT00940000154461; -.
DR   HOGENOM; CLU_000288_57_7_1; -.
DR   InParanoid; Q21215; -.
DR   OMA; CKAMLWD; -.
DR   OrthoDB; 805365at2759; -.
DR   PhylomeDB; Q21215; -.
DR   SignaLink; Q21215; -.
DR   PRO; PR:Q21215; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00010556; Expressed in larva and 4 other tissues.
DR   GO; GO:0030424; C:axon; IDA:WormBase.
DR   GO; GO:0044297; C:cell body; IDA:WormBase.
DR   GO; GO:0005813; C:centrosome; IDA:WormBase.
DR   GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0030426; C:growth cone; IDA:WormBase.
DR   GO; GO:0000776; C:kinetochore; IDA:WormBase.
DR   GO; GO:0005635; C:nuclear envelope; IDA:WormBase.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0015935; C:small ribosomal subunit; IEA:InterPro.
DR   GO; GO:0005080; F:protein kinase C binding; IBA:GO_Central.
DR   GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR   GO; GO:0051304; P:chromosome separation; IMP:WormBase.
DR   GO; GO:0050832; P:defense response to fungus; IMP:WormBase.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR   GO; GO:0000281; P:mitotic cytokinesis; IMP:WormBase.
DR   GO; GO:0008045; P:motor neuron axon guidance; IMP:WormBase.
DR   GO; GO:0040038; P:polar body extrusion after meiotic divisions; IMP:WormBase.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR   GO; GO:0033365; P:protein localization to organelle; IMP:WormBase.
DR   GO; GO:0030334; P:regulation of cell migration; IMP:WormBase.
DR   GO; GO:0072344; P:rescue of stalled ribosome; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR045223; Asc1/RACK1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19868; PTHR19868; 1.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 5.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosomal protein; WD repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:9150941"
FT   CHAIN           2..325
FT                   /note="Guanine nucleotide-binding protein subunit beta-2-
FT                   like 1"
FT                   /id="PRO_0000127739"
FT   REPEAT          5..48
FT                   /note="WD 1"
FT   REPEAT          58..99
FT                   /note="WD 2"
FT   REPEAT          100..141
FT                   /note="WD 3"
FT   REPEAT          143..186
FT                   /note="WD 4"
FT   REPEAT          187..227
FT                   /note="WD 5"
FT   REPEAT          228..268
FT                   /note="WD 6"
FT   REPEAT          269..320
FT                   /note="WD 7"
SQ   SEQUENCE   325 AA;  35830 MW;  C50669418DBCD0A5 CRC64;
     MVQEQMKLTG TLEGHTGWVT QIATYTRNDK TTVLSSSRDK TILVWDVDSV APVDEGPIGR
     PVRSLTGHNH FVSDVVISSD GQFALSGSWD KTLRLWDLNQ GVSTRQFISH TKDVLSVAFS
     ADNRQIVSGS RDKSIKLWNT LAQCKYTITD DCHTDWVSTV RFSPSNRDPV IVSAGWDKVV
     KVWNLGNCRL KTNHIGHTGY VNTVTVSPDG SLCASGGKDG QAMLWDLNEG KHLYTLPGND
     VINAMSFSPN RYWLCAAVGS SIKIWDLEDK KEIEELKPEI ASSGSSRGSS PQCISLAWSQ
     DGQTLFAGYT DNIIRVYQVS IRASN
 
 
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