GBLP_DANRE
ID GBLP_DANRE Reviewed; 317 AA.
AC O42248;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Guanine nucleotide-binding protein subunit beta-2-like 1;
DE AltName: Full=Receptor of activated protein kinase C;
DE Short=RACK;
GN Name=gnb2l1; Synonyms=rack1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10384002; DOI=10.1007/pl00011777;
RA Hamilton L.C., Wright J.M.;
RT "Isolation of complementary DNAs coding for a receptor for activated C
RT kinase (RACK) from zebrafish (Danio rerio) and Tilapia (Oreochromis
RT niloticus): constitutive developmental and tissue expression.";
RL Mar. Biotechnol. 1:279-285(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney marrow;
RX PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA Look A.T., Chen Z.;
RT "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=21262816; DOI=10.1073/pnas.1013170108;
RA Li S., Esterberg R., Lachance V., Ren D., Radde-Gallwitz K., Chi F.,
RA Parent J.L., Fritz A., Chen P.;
RT "Rack1 is required for Vangl2 membrane localization and planar cell
RT polarity signaling while attenuating canonical Wnt activity.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:2264-2269(2011).
CC -!- FUNCTION: Involved in the recruitment, assembly and/or regulation of a
CC variety of signaling molecules. Interacts with a wide variety of
CC proteins and plays a role in many cellular processes (By similarity).
CC Required for VANGL2 membrane localization, inhibits Wnt signaling and
CC regulates cellular polarization and oriented cell division during
CC gastrulation. {ECO:0000250, ECO:0000269|PubMed:21262816}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21262816}.
CC -!- SIMILARITY: Belongs to the WD repeat G protein beta family. Ribosomal
CC protein RACK1 subfamily. {ECO:0000305}.
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DR EMBL; AF025330; AAB81617.1; -; mRNA.
DR EMBL; AY423038; AAQ98014.1; -; mRNA.
DR EMBL; BC049459; AAH49459.1; -; mRNA.
DR RefSeq; NP_571519.1; NM_131444.1.
DR AlphaFoldDB; O42248; -.
DR SMR; O42248; -.
DR STRING; 7955.ENSDARP00000061000; -.
DR PaxDb; O42248; -.
DR Ensembl; ENSDART00000061001; ENSDARP00000061000; ENSDARG00000041619.
DR GeneID; 30722; -.
DR KEGG; dre:30722; -.
DR CTD; 10399; -.
DR ZFIN; ZDB-GENE-990415-89; rack1.
DR eggNOG; KOG0279; Eukaryota.
DR GeneTree; ENSGT00940000154461; -.
DR HOGENOM; CLU_000288_57_7_1; -.
DR InParanoid; O42248; -.
DR OMA; CKAMLWD; -.
DR OrthoDB; 805365at2759; -.
DR PhylomeDB; O42248; -.
DR TreeFam; TF300600; -.
DR Reactome; R-DRE-5357905; Regulation of TNFR1 signaling.
DR Reactome; R-DRE-5357956; TNFR1-induced NFkappaB signaling pathway.
DR Reactome; R-DRE-5626978; TNFR1-mediated ceramide production.
DR PRO; PR:O42248; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 14.
DR Bgee; ENSDARG00000041619; Expressed in presomitic mesoderm and 26 other tissues.
DR ExpressionAtlas; O42248; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:ZFIN.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0015935; C:small ribosomal subunit; IEA:InterPro.
DR GO; GO:0005080; F:protein kinase C binding; IBA:GO_Central.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0001525; P:angiogenesis; IMP:ZFIN.
DR GO; GO:0060027; P:convergent extension involved in gastrulation; IMP:ZFIN.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IMP:UniProtKB.
DR GO; GO:2000543; P:positive regulation of gastrulation; IMP:UniProtKB.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0051302; P:regulation of cell division; IMP:UniProtKB.
DR GO; GO:2000114; P:regulation of establishment of cell polarity; IMP:UniProtKB.
DR GO; GO:0032880; P:regulation of protein localization; IMP:UniProtKB.
DR GO; GO:0072344; P:rescue of stalled ribosome; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR045223; Asc1/RACK1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19868; PTHR19868; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosomal protein; WD repeat.
FT CHAIN 1..317
FT /note="Guanine nucleotide-binding protein subunit beta-2-
FT like 1"
FT /id="PRO_0000127736"
FT REPEAT 13..44
FT /note="WD 1"
FT REPEAT 61..91
FT /note="WD 2"
FT REPEAT 103..133
FT /note="WD 3"
FT REPEAT 146..178
FT /note="WD 4"
FT REPEAT 190..220
FT /note="WD 5"
FT REPEAT 231..260
FT /note="WD 6"
FT REPEAT 281..311
FT /note="WD 7"
SQ SEQUENCE 317 AA; 35123 MW; DEC80E241A22808B CRC64;
MTEQMTVRGT LKGHSGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET NYGIPQRALR
GHSHFVSDVV ISSDGQFALS GSWDGTLRLW DLTTGTTTRR FVGHTKDVLS VAFSADNRQI
VSGSRDKTIK LWNTLGVCKY TIQDDSHTEW VSCVRFSPNS SNPIIVSCGW DKMVKVWNLA
NCKLKTNHIG HTGYLNTVTV SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DGGDTINALC
FSPNRYWLCA ATGPSIKIWD LEGKIIVDEL RQDIITTNSK AEPPQCTSLA WSADGQTLFA
GYTDNLIRVW QVTIGTR
