GBLP_DICDI
ID GBLP_DICDI Reviewed; 329 AA.
AC P46800; Q553X2; Q869Y6;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 07-NOV-2003, sequence version 2.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Guanine nucleotide-binding protein subunit beta-like protein;
GN Name=gpbB; ORFNames=DDB_G0275045;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AX3;
RA Jho E., Kopachik W.;
RT "Cloning of a Dictyostelium discoideum cDNA encodes a G beta subunit-like
RT protein.";
RL Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=AX2;
RX PubMed=16782229; DOI=10.1016/j.ejcb.2006.05.008;
RA Koch K.V., Reinders Y., Ho T.-H., Sickmann A., Graef R.;
RT "Identification and isolation of Dictyostelium microtubule-associated
RT protein interactors by tandem affinity purification.";
RL Eur. J. Cell Biol. 85:1079-1090(2006).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16512674; DOI=10.1021/pr050350q;
RA Reinders Y., Schulz I., Graef R., Sickmann A.;
RT "Identification of novel centrosomal proteins in Dictyostelium discoideum
RT by comparative proteomic approaches.";
RL J. Proteome Res. 5:589-598(2006).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=AX2;
RX PubMed=16926386; DOI=10.1074/mcp.m600113-mcp200;
RA Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA Soldati T.;
RT "Proteomics fingerprinting of phagosome maturation and evidence for the
RT role of a Galpha during uptake.";
RL Mol. Cell. Proteomics 5:2228-2243(2006).
CC -!- SIMILARITY: Belongs to the WD repeat G protein beta family. Ribosomal
CC protein RACK1 subfamily. {ECO:0000305}.
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DR EMBL; U27537; AAA70100.1; -; mRNA.
DR EMBL; AAFI02000013; EAL69803.1; -; Genomic_DNA.
DR RefSeq; XP_643839.1; XM_638747.1.
DR AlphaFoldDB; P46800; -.
DR SMR; P46800; -.
DR IntAct; P46800; 1.
DR STRING; 44689.DDB0185122; -.
DR SWISS-2DPAGE; P46800; -.
DR PaxDb; P46800; -.
DR EnsemblProtists; EAL69803; EAL69803; DDB_G0275045.
DR GeneID; 8619886; -.
DR KEGG; ddi:DDB_G0275045; -.
DR dictyBase; DDB_G0275045; gpbB.
DR eggNOG; KOG0279; Eukaryota.
DR HOGENOM; CLU_000288_57_7_1; -.
DR InParanoid; P46800; -.
DR OMA; CKAMLWD; -.
DR PhylomeDB; P46800; -.
DR PRO; PR:P46800; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0031252; C:cell leading edge; IDA:dictyBase.
DR GO; GO:0071944; C:cell periphery; IDA:dictyBase.
DR GO; GO:0005829; C:cytosol; IDA:dictyBase.
DR GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR GO; GO:0016020; C:membrane; IDA:dictyBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR GO; GO:0015935; C:small ribosomal subunit; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IPI:dictyBase.
DR GO; GO:0035091; F:phosphatidylinositol binding; IDA:dictyBase.
DR GO; GO:0005080; F:protein kinase C binding; IBA:GO_Central.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0072344; P:rescue of stalled ribosome; IBA:GO_Central.
DR GO; GO:0030587; P:sorocarp development; IMP:dictyBase.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR045223; Asc1/RACK1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19868; PTHR19868; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 4.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; Ribonucleoprotein; Ribosomal protein;
KW WD repeat.
FT CHAIN 1..329
FT /note="Guanine nucleotide-binding protein subunit beta-like
FT protein"
FT /id="PRO_0000127742"
FT REPEAT 19..59
FT /note="WD 1"
FT REPEAT 68..107
FT /note="WD 2"
FT REPEAT 110..149
FT /note="WD 3"
FT REPEAT 154..193
FT /note="WD 4"
FT REPEAT 196..235
FT /note="WD 5"
FT REPEAT 237..275
FT /note="WD 6"
FT REPEAT 295..328
FT /note="WD 7"
FT CONFLICT 157..166
FT /note="DWVSCIRFSP -> AVLIGFHVSDSHQ (in Ref. 1; AAA70100)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 329 AA; 36231 MW; AF8621B8C3E4AEFD CRC64;
MEQQKAPQVT YLEVGSLVGH NGFVTSIAVS PENPDTIISS SRDKTVMVWQ LTPTDATSPG
KAHRSLKGHS HFVQDVVISH DGQFALSGSW DNTLRLWDIT KGVSTRLFKG HTQDVMSVAF
SSDNRQIISG SRDATIKVWN TLGECKFTLE GPEAHQDWVS CIRFSPNTPT IVSGSWDNKV
KIWDIKSFKC NHTLTDHTGY VNTVTISPDG SLCASGGKDT FACLWELSSG KPLYKLEARN
TINALAFSPN KYWLSAATDD KIIIWDLLTK QVLAEIVPEV KEQAFDSKKK KESKPKAPAC
LSLAWSADGS VLYAGYNDGL IRVYKSSSQ
