ID   GBLP_LEIIN              Reviewed;         312 AA.
AC   P62884; A4I407; A4I408; A4I409; Q27434;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Guanine nucleotide-binding protein subunit beta-like protein;
DE   AltName: Full=Antigen LACK;
DE   AltName: Full=LiP36;
DE   AltName: Full=p36Li;
GN   Name=LACK1; ORFNames=LINJ_28_2940;
GN   and
GN   Name=LACK2; ORFNames=LINJ_28_2970;
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=PB75;
RX   PubMed=10092881; DOI=10.1046/j.1432-1327.1999.00122.x;
RA   Gonzalez-Aseguinolaza G., Taladriz S., Marquet A., Larraga V.;
RT   "Molecular cloning, cell localization and binding affinity to DNA
RT   replication proteins of the p36/LACK protective antigen from Leishmania
RT   infantum.";
RL   Eur. J. Biochem. 259:909-916(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5;
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Sqaures R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
CC   -!- DEVELOPMENTAL STAGE: Expressed in both stages of the parasite life
CC       cycle.
CC   -!- SIMILARITY: Belongs to the WD repeat G protein beta family. Ribosomal
CC       protein RACK1 subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U49695; AAA91208.1; -; mRNA.
DR   EMBL; FR796460; CAM69514.2; -; Genomic_DNA.
DR   EMBL; FR796460; CAM69516.2; -; Genomic_DNA.
DR   RefSeq; XP_001470319.2; XM_001470282.2.
DR   RefSeq; XP_001470321.2; XM_001470284.2.
DR   AlphaFoldDB; P62884; -.
DR   SMR; P62884; -.
DR   STRING; 5671.XP_001470319.2; -.
DR   GeneID; 5070507; -.
DR   GeneID; 5070509; -.
DR   KEGG; lif:LINJ_28_2940; -.
DR   KEGG; lif:LINJ_28_2970; -.
DR   VEuPathDB; TriTrypDB:LINF_280034800; -.
DR   eggNOG; KOG0279; Eukaryota.
DR   InParanoid; P62884; -.
DR   OMA; CKAMLWD; -.
DR   Proteomes; UP000008153; Chromosome 28.
DR   GO; GO:0015935; C:small ribosomal subunit; IEA:InterPro.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR045223; Asc1/RACK1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19868; PTHR19868; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; Ribonucleoprotein; Ribosomal protein;
KW   WD repeat.
FT   CHAIN           1..312
FT                   /note="Guanine nucleotide-binding protein subunit beta-like
FT                   protein"
FT                   /id="PRO_0000127744"
FT   REPEAT          9..42
FT                   /note="WD 1"
FT   REPEAT          63..93
FT                   /note="WD 2"
FT   REPEAT          105..135
FT                   /note="WD 3"
FT   REPEAT          148..180
FT                   /note="WD 4"
FT   REPEAT          192..222
FT                   /note="WD 5"
FT   REPEAT          233..262
FT                   /note="WD 6"
FT   REPEAT          279..307
FT                   /note="WD 7"
SQ   SEQUENCE   312 AA;  34373 MW;  778321761BBCCD99 CRC64;
     MNYEGHLKGH RGWVTSLACP QQAGSYIKVV STSRDGTAIS WKANPDRHSV DSDYGLPSHR
     LEGHTGFVSC VSLAHATDYA LTASWDRSIR MWDLRNGQCQ RKFLKHTKDV LAVAFSPDDR
     LIVSAGRDNV IRVWNVAGEC MHEFLRDGHE DWVSSICFSP SLEHPIVVSG SWDNTIKVWN
     VNGGKCERTL KGHSNYVSTV TVSPDGSLCA SGGKDGAALL WDLSTGEQLF KINVESPINQ
     IAFSPNRFWM CVATERSLSV YDLESKAVIA ELTPDGAKPS ECISIAWSAD GNTLYSGHKD
     NLIRVWSISD AE