ID   GBLP_LEIMA              Reviewed;         312 AA.
AC   Q25306;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Guanine nucleotide-binding protein subunit beta-like protein;
DE   AltName: Full=Antigen LACK;
OS   Leishmania major.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7725103; DOI=10.1126/science.7725103;
RA   Mougneau E., Altare F., Wakil A.E., Zheng S., Coppola T., Wang Z.E.,
RA   Waldmann R., Locksley R.M., Glaichenhaus N.;
RT   "Expression cloning of a protective Leishmania antigen.";
RL   Science 268:563-566(1995).
CC   -!- DEVELOPMENTAL STAGE: Expressed in both stages of the parasite life
CC       cycle.
CC   -!- SIMILARITY: Belongs to the WD repeat G protein beta family. Ribosomal
CC       protein RACK1 subfamily. {ECO:0000305}.
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DR   EMBL; U27568; AAA97577.1; -; mRNA.
DR   AlphaFoldDB; Q25306; -.
DR   SMR; Q25306; -.
DR   STRING; 5664.LmjF.28.2740; -.
DR   VEuPathDB; TriTrypDB:LmjF.28.2740; -.
DR   VEuPathDB; TriTrypDB:LMJLV39_280035800; -.
DR   VEuPathDB; TriTrypDB:LMJSD75_280035600; -.
DR   eggNOG; KOG0279; Eukaryota.
DR   GO; GO:0015935; C:small ribosomal subunit; IEA:InterPro.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR045223; Asc1/RACK1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19868; PTHR19868; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Repeat; Ribonucleoprotein; Ribosomal protein; WD repeat.
FT   CHAIN           1..312
FT                   /note="Guanine nucleotide-binding protein subunit beta-like
FT                   protein"
FT                   /id="PRO_0000127745"
FT   REPEAT          9..42
FT                   /note="WD 1"
FT   REPEAT          63..93
FT                   /note="WD 2"
FT   REPEAT          105..135
FT                   /note="WD 3"
FT   REPEAT          148..180
FT                   /note="WD 4"
FT   REPEAT          192..222
FT                   /note="WD 5"
FT   REPEAT          233..262
FT                   /note="WD 6"
FT   REPEAT          279..307
FT                   /note="WD 7"
SQ   SEQUENCE   312 AA;  34414 MW;  B094B566A5ACC1D3 CRC64;
     MNYEGHLKGH RGWVTSLACP QQAGSYIKVV STSRDGTVIS WKANPDRHSV DSDYGLPNHR
     LEGHTGFVSC VSLAHATDYA LTASWDRSIR MWDLRNGQCQ RKFLKHTKDV LAVAFSPDDR
     LIVSAGRDNV IRVWNVAGEC MHEFLRDGHE DWVSSICFSP SLEHPIVVSG SWDNTIKVWN
     VNGGKCERTL KGHSNYVSTV TVSPDGSLCA SGGKDGAALL WDLSTGEQLF KINVESPINQ
     IGFSPNRFWM CVATERSLSV YDLESKAVIA ELTPDGAKPS ECISIAWSAD GNTLYSGHKD
     NLIRVWSISD AE