GBLP_NEUCR
ID GBLP_NEUCR Reviewed; 316 AA.
AC Q01369; Q7S5N3;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Guanine nucleotide-binding protein subunit beta-like protein;
DE AltName: Full=Cross-pathway control WD-repeat protein cpc-2;
GN Name=cpc-2; ORFNames=NCU05810;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=7651339; DOI=10.1007/bf02190797;
RA Mueller F., Krueger D., Sattlegger E., Hoffmann B., Ballario P., Kanaan M.,
RA Barthelmess I.B.;
RT "The cpc-2 gene of Neurospora crassa encodes a protein entirely composed of
RT WD-repeat segments that is involved in general amino acid control and
RT female fertility.";
RL Mol. Gen. Genet. 248:162-173(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Required to activate general amino acid control under
CC conditions of amino acid limitation in the vegetative growth phase, and
CC for formation of protoperithecia in preparation for the sexual phase of
CC the life cycle of N.crassa.
CC -!- SIMILARITY: Belongs to the WD repeat G protein beta family. Ribosomal
CC protein RACK1 subfamily. {ECO:0000305}.
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DR EMBL; X81875; CAA57460.1; -; Genomic_DNA.
DR EMBL; CM002242; EAA30834.1; -; Genomic_DNA.
DR PIR; S57839; S57839.
DR RefSeq; XP_960070.1; XM_954977.3.
DR PDB; 7R81; EM; 2.70 A; h2=1-316.
DR PDBsum; 7R81; -.
DR AlphaFoldDB; Q01369; -.
DR SMR; Q01369; -.
DR STRING; 5141.EFNCRP00000005670; -.
DR PRIDE; Q01369; -.
DR EnsemblFungi; EAA30834; EAA30834; NCU05810.
DR GeneID; 3876201; -.
DR KEGG; ncr:NCU05810; -.
DR HOGENOM; CLU_000288_57_7_1; -.
DR InParanoid; Q01369; -.
DR Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IEA:EnsemblFungi.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001965; F:G-protein alpha-subunit binding; IEA:EnsemblFungi.
DR GO; GO:0005092; F:GDP-dissociation inhibitor activity; IEA:EnsemblFungi.
DR GO; GO:0005080; F:protein kinase C binding; IBA:GO_Central.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:EnsemblFungi.
DR GO; GO:0140469; P:GCN2-mediated signaling; IEA:EnsemblFungi.
DR GO; GO:0001403; P:invasive growth in response to glucose limitation; IEA:EnsemblFungi.
DR GO; GO:0061157; P:mRNA destabilization; IEA:EnsemblFungi.
DR GO; GO:1903138; P:negative regulation of cell wall integrity MAPK cascade; IEA:EnsemblFungi.
DR GO; GO:1902660; P:negative regulation of glucose mediated signaling pathway; IEA:EnsemblFungi.
DR GO; GO:1903753; P:negative regulation of p38MAPK cascade; IEA:EnsemblFungi.
DR GO; GO:2001125; P:negative regulation of translational frameshifting; IEA:EnsemblFungi.
DR GO; GO:0010508; P:positive regulation of autophagy; IEA:EnsemblFungi.
DR GO; GO:0031139; P:positive regulation of conjugation with cellular fusion; IEA:EnsemblFungi.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0008104; P:protein localization; IEA:EnsemblFungi.
DR GO; GO:2000765; P:regulation of cytoplasmic translation; IEA:EnsemblFungi.
DR GO; GO:0032995; P:regulation of fungal-type cell wall biogenesis; IEA:EnsemblFungi.
DR GO; GO:0072344; P:rescue of stalled ribosome; IBA:GO_Central.
DR GO; GO:1990116; P:ribosome-associated ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR045223; Asc1/RACK1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19868; PTHR19868; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 5.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Repeat; Ribonucleoprotein;
KW Ribosomal protein; WD repeat.
FT CHAIN 1..316
FT /note="Guanine nucleotide-binding protein subunit beta-like
FT protein"
FT /id="PRO_0000127756"
FT REPEAT 13..44
FT /note="WD 1"
FT REPEAT 61..91
FT /note="WD 2"
FT REPEAT 103..133
FT /note="WD 3"
FT REPEAT 146..178
FT /note="WD 4"
FT REPEAT 190..220
FT /note="WD 5"
FT REPEAT 231..260
FT /note="WD 6"
FT REPEAT 281..311
FT /note="WD 7"
FT CONFLICT 128
FT /note="T -> S (in Ref. 2; EAA30834)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 316 AA; 35131 MW; E3CC1F9A08090F17 CRC64;
MAEQLILKGT LEGHNGWVTS LATSLENPNM LLSGSRDKSL IIWNLTRDET SYGYPKRRLH
GHSHIVSDCV ISSDGAYALS ASWDKTLRLW ELSTGTTTRR FVGHTNDVLS VSFSADNRQI
VSGSRDRTIK LWNTLGDCKF TITEKGHTEW VSCVRFSPNP QNPVIVSSGW DKLVKVWELS
SCKLQTDHIG HTGYINAVTI SPDGSLCASG GKDGTTMLWD LNESKHLYSL NANDEIHALV
FSPNRYWLCA ATSSSIIIFD LEKKSKVDEL KPEFQNIGKK SREPECVSLA WSADGQTLFA
GYTDNIIRAW GVMSRA
