ID   GBLP_ORENI              Reviewed;         317 AA.
AC   O42249;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Guanine nucleotide-binding protein subunit beta-2-like 1;
DE   AltName: Full=Receptor of activated protein kinase C;
DE            Short=RACK;
GN   Name=gnb2l1; Synonyms=rack1;
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=10384002; DOI=10.1007/pl00011777;
RA   Hamilton L.C., Wright J.M.;
RT   "Isolation of complementary DNAs coding for a receptor for activated C
RT   kinase (RACK) from zebrafish (Danio rerio) and Tilapia (Oreochromis
RT   niloticus): constitutive developmental and tissue expression.";
RL   Mar. Biotechnol. 1:279-285(1999).
CC   -!- FUNCTION: Involved in the recruitment, assembly and/or regulation of a
CC       variety of signaling molecules. Interacts with a wide variety of
CC       proteins and plays a role in many cellular processes. Required for
CC       VANGL2 membrane localization, inhibits Wnt signaling and regulates
CC       cellular polarization and oriented cell division during gastrulation
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O42248}.
CC   -!- SIMILARITY: Belongs to the WD repeat G protein beta family. Ribosomal
CC       protein RACK1 subfamily. {ECO:0000305}.
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DR   EMBL; AF025331; AAB81618.1; -; mRNA.
DR   RefSeq; NP_001266445.1; NM_001279516.1.
DR   AlphaFoldDB; O42249; -.
DR   SMR; O42249; -.
DR   STRING; 8128.ENSONIP00000016329; -.
DR   GeneID; 100534572; -.
DR   KEGG; onl:100534572; -.
DR   CTD; 10399; -.
DR   eggNOG; KOG0279; Eukaryota.
DR   InParanoid; O42249; -.
DR   OrthoDB; 805365at2759; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0015935; C:small ribosomal subunit; IEA:InterPro.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; ISS:UniProtKB.
DR   GO; GO:2000543; P:positive regulation of gastrulation; ISS:UniProtKB.
DR   GO; GO:0051302; P:regulation of cell division; ISS:UniProtKB.
DR   GO; GO:2000114; P:regulation of establishment of cell polarity; ISS:UniProtKB.
DR   GO; GO:0032880; P:regulation of protein localization; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR045223; Asc1/RACK1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19868; PTHR19868; 1.
DR   Pfam; PF00400; WD40; 7.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Repeat; Ribonucleoprotein;
KW   Ribosomal protein; WD repeat.
FT   CHAIN           1..317
FT                   /note="Guanine nucleotide-binding protein subunit beta-2-
FT                   like 1"
FT                   /id="PRO_0000127737"
FT   REPEAT          13..44
FT                   /note="WD 1"
FT   REPEAT          61..91
FT                   /note="WD 2"
FT   REPEAT          103..133
FT                   /note="WD 3"
FT   REPEAT          146..178
FT                   /note="WD 4"
FT   REPEAT          190..220
FT                   /note="WD 5"
FT   REPEAT          231..260
FT                   /note="WD 6"
FT   REPEAT          281..311
FT                   /note="WD 7"
SQ   SEQUENCE   317 AA;  35107 MW;  4DA8360358D9BD99 CRC64;
     MTEQMTVRGT LKGHSGWVTQ IATTPKYPDM ILSASRDKSI IMWKLTRDET NYGIPQRSLK
     GHSHFVSDVV ISSDGQFALS GAWDGTLRLW DLTTGLTTRR FVGHTKDVLS VAFSADNRQI
     VSGSRDKTIK LWNTLGVCKY TIQDEGHTEW VSCVRFSPNS SNPIIVSCGW DKMVKVWNLA
     NCKLKTNHIG HTGYLNTVTV SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DSGDVINALC
     FSPNRYWLCA ATGPSIKIWD LEGKIIVDEL RQEVISTNSK AEPPQCTSLA WSADGQTLFA
     GYTDNLIRVW QVTIGTR