ID   GBP6_PONAB              Reviewed;         633 AA.
AC   Q5R9T9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Guanylate-binding protein 6;
DE            EC=3.6.5.- {ECO:0000250|UniProtKB:P32455};
DE   AltName: Full=GTP-binding protein 6;
DE            Short=GBP-6;
DE   AltName: Full=Guanine nucleotide-binding protein 6;
GN   Name=GBP6;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions (By
CC       similarity). Confers protection to several pathogens, including the
CC       bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG
CC       as well as the protozoan pathogen Toxoplasma gondii (By similarity).
CC       {ECO:0000250|UniProtKB:A0A0G2JDV3, ECO:0000250|UniProtKB:P32455}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000250|UniProtKB:P32455};
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle
CC       {ECO:0000250|UniProtKB:A0A0G2JDV3}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. GB1/RHD3 GTPase family. GB1 subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU01052}.
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DR   EMBL; CR859293; CAH91471.1; -; mRNA.
DR   RefSeq; NP_001125866.1; NM_001132394.1.
DR   AlphaFoldDB; Q5R9T9; -.
DR   SMR; Q5R9T9; -.
DR   STRING; 9601.ENSPPYP00000001356; -.
DR   GeneID; 100172797; -.
DR   KEGG; pon:100172797; -.
DR   CTD; 163351; -.
DR   eggNOG; KOG2037; Eukaryota.
DR   InParanoid; Q5R9T9; -.
DR   OrthoDB; 1027269at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0071346; P:cellular response to interferon-gamma; ISS:CAFA.
DR   GO; GO:0042742; P:defense response to bacterium; ISS:CAFA.
DR   GO; GO:0006955; P:immune response; ISS:CAFA.
DR   CDD; cd16269; GBP_C; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030386; G_GB1_RHD3_dom.
DR   InterPro; IPR037684; GBP_C.
DR   InterPro; IPR003191; Guanylate-bd/ATL_C.
DR   InterPro; IPR036543; Guanylate-bd_C_sf.
DR   InterPro; IPR015894; Guanylate-bd_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF02263; GBP; 1.
DR   Pfam; PF02841; GBP_C; 1.
DR   SUPFAM; SSF48340; SSF48340; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51715; G_GB1_RHD3; 1.
PE   2: Evidence at transcript level;
KW   Antimicrobial; Cytoplasmic vesicle; GTP-binding; Hydrolase; Immunity;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..633
FT                   /note="Guanylate-binding protein 6"
FT                   /id="PRO_0000313812"
FT   DOMAIN          35..277
FT                   /note="GB1/RHD3-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01052"
FT   REGION          1..310
FT                   /note="GTPase domain (Globular)"
FT                   /evidence="ECO:0000250|UniProtKB:P32455"
FT   BINDING         45..52
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P32455"
FT   BINDING         67..69
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P32455"
FT   BINDING         97..101
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:P32455"
SQ   SEQUENCE   633 AA;  72364 MW;  B29DD1EE666DD76F CRC64;
     MESGPKMLAP ICLVENNNEQ LLVNQQAIQI LEKISQPVVV VAIVGLYRTG KSYLMNHLAG
     QNHGFPLGST VQSETKGIWM WCVPHPSKPN HTLVLLDTEG LGDVEKGDPK NDSWIFALAV
     LLCSTFIYNS MSTINHQALE QLHYVTELTE LIKAKSSPRP DGVDDSTEFV SFFPDFIWTV
     RDFTLELKLN GHPITEDEYL ENALKLIQGN NPRVQTSNLP RECIRRFFPK RKCFIFDRPT
     NDKDLLANIE KVSEKQLDPK FQEQTNIFSS YIFTHARTKT LREGIIVTGN RLGTLAVTYV
     EAVNSGAVPC LENAVITLAQ RENSAAVQRA ADYYSQQMAQ RVKFPTDTLQ ELLDMHAACE
     REAIAIFMEH SFKDENQEFQ KKFMETTMNK KGDFLLQNEE SSVQYCQAKL NELSKGLMES
     ISAGSFSVPG GHKLYMETKE RIEQDYWQVP RKGVKAKEVF QRFLESQVVI EESILQSDKA
     LTDREKAVAV DRAKKEAAEK EQELLKQKLQ EQQQQMEAQD KSLKENIAQL KQKLQMEREQ
     LLREQIMMLE HTQKVQNDWL HEGFKKKYEE MNAEISQFKR MIDITKNDDT PWIARTLDKL
     ADELTAVLSA PAKLIGHGVK GVSSLFKKHK LPF