ID   GBPR_RHIRD              Reviewed;         302 AA.
AC   P25547;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 2.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=HTH-type transcriptional regulator GbpR;
DE   AltName: Full=Galactose-binding protein regulator;
DE            Short=GBP regulator;
GN   Name=gbpR; Synonyms=chvO;
OS   Rhizobium radiobacter (Agrobacterium tumefaciens) (Agrobacterium
OS   radiobacter).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC   Agrobacterium tumefaciens complex.
OX   NCBI_TaxID=358;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A348;
RX   PubMed=8253677; DOI=10.1128/jb.175.24.7880-7886.1993;
RA   Doty S.L., Chang M., Nester E.W.;
RT   "The chromosomal virulence gene, chvE, of Agrobacterium tumefaciens is
RT   regulated by a LysR family member.";
RL   J. Bacteriol. 175:7880-7886(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-252.
RX   PubMed=2156804; DOI=10.1128/jb.172.4.1814-1822.1990;
RA   Huang M.-L.W., Cangelosi G.A., Halperin W., Nester E.W.;
RT   "A chromosomal Agrobacterium tumefaciens gene required for effective plant
RT   signal transduction.";
RL   J. Bacteriol. 172:1814-1822(1990).
CC   -!- FUNCTION: Activator of the expression of chvE when bound to its inducer
CC       and represses its expression in the absence of inducer (L-arabinose, D-
CC       fucose or D-galactose). Negatively regulates its own expression.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L10424; AAA16197.1; -; Unassigned_DNA.
DR   EMBL; M30318; AAA22108.2; -; Genomic_DNA.
DR   PIR; I39716; I39716.
DR   AlphaFoldDB; P25547; -.
DR   SMR; P25547; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd08435; PBP2_GbpR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037405; GbpR_PBP2.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..302
FT                   /note="HTH-type transcriptional regulator GbpR"
FT                   /id="PRO_0000105623"
FT   DOMAIN          1..56
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        16..35
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   CONFLICT        61..62
FT                   /note="Missing (in Ref. 2; AAA22108)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   302 AA;  32767 MW;  F557BB81C6895C7D CRC64;
     MSHLRMLVMI EEHGQVSAAA AAMNMTQPAA SRMLSEMEAI VKSPLCQRAS RGVVLTKFGE
     ALALARRART ILLELREASR ELNQMKSGSG GSVYIGAVTA PAISLVVPAI RRAMDTYPGI
     EINVQVESSN VLARELLAAR HDFIIGRIPD DFDPGLFSIH EIGIERACLV VREGHPLMRG
     EPVTLQDLSG YDWVFQPPGA LLRRTMEDVF LTHGVAMPRN VINTPSVVLT LALVCNTNAI
     APIAQDMAEF VAGQQADMAE PAFCQRISNS WSSLTASLPP KAGSCRPAPA CFMIWCWMKA
     VS