ID   GBP_COTKA               Reviewed;          25 AA.
AC   P22800;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Growth-blocking peptide;
DE            Short=GBP;
DE   AltName: Full=Juvenile hormone esterase activity repressive peptide;
OS   Cotesia kariyai (Parasitic wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Parasitoida;
OC   Ichneumonoidea; Braconidae; Microgastrinae; Cotesia.
OX   NCBI_TaxID=178385;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT GLN-25.
RX   PubMed=2022627; DOI=10.1016/s0021-9258(18)92927-3;
RA   Hayakawa Y.;
RT   "Structure of a growth-blocking peptide present in parasitized insect
RT   hemolymph.";
RL   J. Biol. Chem. 266:7982-7984(1991).
CC   -!- FUNCTION: Biogenic peptide that prevents, in lepidopteran, the onset of
CC       metamorphosis from larva to pupa. This growth-blocking peptide has
CC       repressive activity against juvenile hormone esterase.
CC   -!- TISSUE SPECIFICITY: Hemolymph.
CC   -!- SIMILARITY: Belongs to the GBP/PSP1/paralytic peptide family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P22800; -.
DR   SMR; P22800; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   InterPro; IPR003463; GBP_PSP.
DR   Pfam; PF02425; GBP_PSP; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cytokine; Direct protein sequencing; Disulfide bond.
FT   PEPTIDE         1..25
FT                   /note="Growth-blocking peptide"
FT                   /id="PRO_0000043907"
FT   MOD_RES         25
FT                   /note="Glutamine amide"
FT                   /evidence="ECO:0000269|PubMed:2022627"
FT   DISULFID        7..19
SQ   SEQUENCE   25 AA;  2785 MW;  13C6E963CB436D65 CRC64;
     ENFSGGCVAG YMRTPDGRCK PTFYQ