ID   GBP_XENLA               Reviewed;         169 AA.
AC   O93343; Q6DFG6;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=GSK-3-binding protein;
DE            Short=GBP;
GN   Name=gbp;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Oocyte;
RX   PubMed=9635432; DOI=10.1016/s0092-8674(00)81208-8;
RA   Yost C., Farr G.H. III, Pierce S.B., Ferkey D.M., Chen M.M., Kimelman D.;
RT   "GBP, an inhibitor of GSK-3, is implicated in Xenopus development and
RT   oncogenesis.";
RL   Cell 93:1031-1041(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds GSK-3 and prevents GSK-3-dependent phosphorylation.
CC       Regulates the stability of beta-catenin in embryos. Maternal GBP is
CC       required for dorsal-ventral axis formation.
CC   -!- DEVELOPMENTAL STAGE: Expressed at constant levels in the oocyte and
CC       early embryo.
CC   -!- SIMILARITY: Belongs to the GSK-3-binding protein family. {ECO:0000305}.
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DR   EMBL; AF062738; AAC41303.1; -; mRNA.
DR   EMBL; BC076771; AAH76771.1; -; mRNA.
DR   RefSeq; NP_001081774.1; NM_001088305.1.
DR   AlphaFoldDB; O93343; -.
DR   SMR; O93343; -.
DR   DNASU; 398043; -.
DR   GeneID; 398043; -.
DR   KEGG; xla:398043; -.
DR   CTD; 398043; -.
DR   Xenbase; XB-GENE-865735; frat1.S.
DR   OrthoDB; 1477860at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 398043; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0009950; P:dorsal/ventral axis specification; IMP:UniProtKB.
DR   InterPro; IPR008014; GSK3-bd.
DR   PANTHER; PTHR35154; PTHR35154; 1.
DR   Pfam; PF05350; GSK-3_bind; 2.
PE   1: Evidence at protein level;
KW   Developmental protein; Reference proteome.
FT   CHAIN           1..169
FT                   /note="GSK-3-binding protein"
FT                   /id="PRO_0000087435"
FT   REGION          75..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          122..145
FT                   /note="Involved in GSK-3 binding"
FT   REGION          147..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..94
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         139..140
FT                   /note="KE->AQ: Abolishes GSK-3 binding activity."
SQ   SEQUENCE   169 AA;  18385 MW;  299A488E369F3446 CRC64;
     MPCRKESFLL LEQSVTVGSG EVDTLVARIG EALQLNAQRT PTSCSMAYGA LKPVSRAGPS
     CSCVRGRSTP YPVCTPRGAA RHAQHHHHHS PRQQGTGGNK RLCGRGWGRC NCRKHAGTEE
     EDDPHELLQE LLLSGNLIKE AVRRLHMAGE SPDPPGSRRV SECTETTVQ