GBRB4_CHICK
ID GBRB4_CHICK Reviewed; 488 AA.
AC P24045; Q6LBM6;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-1992, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Gamma-aminobutyric acid receptor subunit beta-4;
DE AltName: Full=GABA(A) receptor subunit beta-4;
DE Flags: Precursor;
GN Name=GABRB4;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS BETA-4 AND BETA-4').
RC STRAIN=Rhode Island; TISSUE=Brain, and Liver;
RX PubMed=1848280; DOI=10.1111/j.1471-4159.1991.tb11443.x;
RA Bateson A.N., Lasham A., Darlison M.G.;
RT "Gamma-aminobutyric acid A receptor heterogeneity is increased by
RT alternative splicing of a novel beta-subunit gene transcript.";
RL J. Neurochem. 56:1437-1440(1991).
CC -!- FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate
CC brain, mediates neuronal inhibition by binding to the
CC GABA/benzodiazepine receptor and opening an integral chloride channel.
CC -!- SUBUNIT: Generally pentameric. There are five types of GABA(A) receptor
CC chains: alpha, beta, gamma, delta, and rho.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane
CC protein. Cell membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Beta-4';
CC IsoId=P24045-1; Sequence=Displayed;
CC Name=Beta-4;
CC IsoId=P24045-2; Sequence=VSP_000089;
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB4 sub-
CC subfamily. {ECO:0000305}.
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DR EMBL; X56647; CAA39969.1; -; mRNA.
DR EMBL; X56648; CAA39970.1; ALT_SEQ; mRNA.
DR EMBL; X56646; CAA39968.1; -; Genomic_DNA.
DR PIR; JH0359; JH0359.
DR RefSeq; NP_001161175.1; NM_001167703.1. [P24045-1]
DR RefSeq; NP_001161176.1; NM_001167704.1. [P24045-2]
DR AlphaFoldDB; P24045; -.
DR SMR; P24045; -.
DR STRING; 9031.ENSGALP00000011732; -.
DR PaxDb; P24045; -.
DR Ensembl; ENSGALT00000055905; ENSGALP00000058040; ENSGALG00000033183. [P24045-1]
DR GeneID; 396288; -.
DR KEGG; gga:396288; -.
DR CTD; 55879; -.
DR VEuPathDB; HostDB:geneid_396288; -.
DR eggNOG; KOG3643; Eukaryota.
DR GeneTree; ENSGT00940000164188; -.
DR HOGENOM; CLU_010920_0_1_1; -.
DR InParanoid; P24045; -.
DR OMA; CLACCAQ; -.
DR OrthoDB; 480926at2759; -.
DR PhylomeDB; P24045; -.
DR TreeFam; TF315453; -.
DR Reactome; R-GGA-977443; GABA receptor activation.
DR PRO; PR:P24045; -.
DR Proteomes; UP000000539; Chromosome 4.
DR Bgee; ENSGALG00000033183; Expressed in brain and 2 other tissues.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:1902711; C:GABA-A receptor complex; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.58.390; -; 1.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR002289; GABAAb_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR01160; GABAARBETA.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Chloride; Chloride channel;
KW Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor;
KW Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..25
FT CHAIN 26..488
FT /note="Gamma-aminobutyric acid receptor subunit beta-4"
FT /id="PRO_0000000466"
FT TOPO_DOM 26..244
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 245..266
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TRANSMEM 271..292
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TRANSMEM 304..326
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 327..465
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 466..487
FT /note="Helical"
FT /evidence="ECO:0000305"
FT CARBOHYD 32
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 173
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 160..174
FT /evidence="ECO:0000250"
FT VAR_SEQ 361..364
FT /note="Missing (in isoform Beta-4)"
FT /evidence="ECO:0000303|PubMed:1848280"
FT /id="VSP_000089"
SQ SEQUENCE 488 AA; 56069 MW; 164A75314BDB2C12 CRC64;
MWTFQADRLS GIVSALAALC VACCAQSPST GNISVVKEIV DKLLKGYDVR LRPDFGGNPV
TVGMSIHISS IDQISEVNMD YTITMYFQQS WRDKRLAYND LPLNLTLDNR VADQLWLPDT
YFLNDKKSFL HGVTVKNRMI RLHPDGTVLY GLRITTTAAC MMDLRRYPLD QQNCTLEIES
YGYTVDDIVF FWQGNDSAVT GMEVLELPQF TIIEQRLVSR EVVFTTGSYL RLSLSFRIKR
NIGYFILQTY MPSILITILS WVSFWINYDA SAARVALGVT TVLTMTTINT HLRETLPKIP
YVKAIDVYLM GCFVFVFLAL LEYAFVNYIF FGRGPRQQKK QSERISKANN ERHRYEEKRV
REQVDPYGNI LLSTLDMNNE LLATDMMSSV GDSRNSVMSF EGSGIQFRKP LASRDGFGHH
PTLDRHVPLT HHAAARNRAN CRLRRRSSKL KLKIPDLTDV STIDKWSRII FPITFGFFNL
VYWLYYVN
