GBRD_MOUSE
ID GBRD_MOUSE Reviewed; 449 AA.
AC P22933;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1991, sequence version 1.
DT 03-AUG-2022, entry version 180.
DE RecName: Full=Gamma-aminobutyric acid receptor subunit delta;
DE AltName: Full=GABA(A) receptor subunit delta;
DE Flags: Precursor;
GN Name=Gabrd;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2176788; DOI=10.1089/dna.1990.9.561;
RA Sommer B., Poustka A., Spurr N.K., Seeburg P.H.;
RT "The murine GABAA receptor delta-subunit gene: structure and assignment to
RT human chromosome 1.";
RL DNA Cell Biol. 9:561-568(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=DBA/2J; TISSUE=Brain;
RX PubMed=1324097; DOI=10.1016/0361-9230(92)90015-p;
RA Wang J.B., Kofuji P., Burt D.R.;
RT "Strain comparisons and developmental profile of the delta subunit of the
RT murine GABAA receptor.";
RL Brain Res. Bull. 29:119-123(1992).
CC -!- FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate
CC brain, mediates neuronal inhibition by binding to the
CC GABA/benzodiazepine receptor and opening an integral chloride channel.
CC -!- SUBUNIT: Generally pentameric. There are five types of GABA(A) receptor
CC subunits: alpha, beta, gamma, delta, and rho.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane
CC protein. Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRD sub-
CC subfamily. {ECO:0000305}.
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DR EMBL; AH001900; AAA37652.1; -; Genomic_DNA.
DR EMBL; S42882; AAB22967.1; -; mRNA.
DR CCDS; CCDS19028.1; -.
DR PIR; A36303; A36303.
DR PIR; I52630; I52630.
DR RefSeq; NP_032098.2; NM_008072.2.
DR AlphaFoldDB; P22933; -.
DR SMR; P22933; -.
DR ComplexPortal; CPX-2986; GABA-A receptor, alpha-6/beta-3/delta.
DR ComplexPortal; CPX-2987; GABA-A receptor, alpha-6/beta-2/delta.
DR ComplexPortal; CPX-2988; GABA-A receptor, alpha-4/beta-2/delta.
DR ComplexPortal; CPX-2989; GABA-A receptor, alpha-4/beta-3/delta.
DR STRING; 10090.ENSMUSP00000030925; -.
DR ChEMBL; CHEMBL2094133; -.
DR DrugCentral; P22933; -.
DR GlyGen; P22933; 2 sites.
DR iPTMnet; P22933; -.
DR PhosphoSitePlus; P22933; -.
DR PaxDb; P22933; -.
DR PeptideAtlas; P22933; -.
DR PRIDE; P22933; -.
DR ProteomicsDB; 266781; -.
DR ABCD; P22933; 1 sequenced antibody.
DR Antibodypedia; 12525; 254 antibodies from 32 providers.
DR DNASU; 14403; -.
DR Ensembl; ENSMUST00000030925; ENSMUSP00000030925; ENSMUSG00000029054.
DR GeneID; 14403; -.
DR KEGG; mmu:14403; -.
DR UCSC; uc008wdf.2; mouse.
DR CTD; 2563; -.
DR MGI; MGI:95622; Gabrd.
DR VEuPathDB; HostDB:ENSMUSG00000029054; -.
DR eggNOG; KOG3643; Eukaryota.
DR GeneTree; ENSGT00940000160122; -.
DR HOGENOM; CLU_010920_0_1_1; -.
DR InParanoid; P22933; -.
DR OMA; YRCVEME; -.
DR OrthoDB; 480926at2759; -.
DR PhylomeDB; P22933; -.
DR TreeFam; TF315453; -.
DR BioGRID-ORCS; 14403; 1 hit in 74 CRISPR screens.
DR ChiTaRS; Gabrd; mouse.
DR PRO; PR:P22933; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; P22933; protein.
DR Bgee; ENSMUSG00000029054; Expressed in cerebellar cortex and 76 other tissues.
DR ExpressionAtlas; P22933; baseline and differential.
DR Genevisible; P22933; MM.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0030424; C:axon; IDA:CACAO.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0030425; C:dendrite; IDA:CACAO.
DR GO; GO:1902711; C:GABA-A receptor complex; IBA:GO_Central.
DR GO; GO:0098982; C:GABA-ergic synapse; IDA:SynGO.
DR GO; GO:0098978; C:glutamatergic synapse; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0099055; C:integral component of postsynaptic membrane; IDA:SynGO.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0043025; C:neuronal cell body; IDA:CACAO.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0004890; F:GABA-A receptor activity; ISO:MGI.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IDA:SynGO.
DR GO; GO:0007268; P:chemical synaptic transmission; ISO:MGI.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.58.390; -; 1.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR008098; GABAAd_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR PANTHER; PTHR18945:SF34; PTHR18945:SF34; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR01722; GABAARDELTA.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Chloride; Chloride channel; Disulfide bond; Glycoprotein;
KW Ion channel; Ion transport; Membrane; Phosphoprotein;
KW Postsynaptic cell membrane; Reference proteome; Signal; Synapse;
KW Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..16
FT CHAIN 17..449
FT /note="Gamma-aminobutyric acid receptor subunit delta"
FT /id="PRO_0000000469"
FT TOPO_DOM 17..248
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 249..271
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TRANSMEM 275..297
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TRANSMEM 309..331
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 332..426
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 427..449
FT /note="Helical"
FT /evidence="ECO:0000305"
FT MOD_RES 390
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P18506"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 106
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 164..178
FT /evidence="ECO:0000250"
FT CONFLICT 255
FT /note="Y -> H (in Ref. 2; AAB22967)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 449 AA; 50522 MW; C00BCA1C3322BF19 CRC64;
MDVLGWLLLP LLLLCTQPHH GARAMNDIGD YVGSNLEISW LPNLDGLMEG YARNFRPGIG
GAPVNVALAL EVASIDHISE ANMEYTMTVF LHQSWRDSRL SYNHTNETLG LDSRFVDKLW
LPDTFIVNAK SAWFHDVTVE NKLIRLQPDG VILYSIRITS TVACDMDLAK YPLDEQECML
DLESYGYSSE DIVYYWSENQ EQIHGLDRLQ LAQFTITSYR FTTELMNFKS AGQFPRLSLH
FQLRRNRGVY IIQSYMPSVL LVAMSWVSFW ISQAAVPARV SLGITTVLTM TTLMVSARSS
LPRASAIKAL DVYFWICYVF VFAALVEYAF AHFNADYRKK RKAKVKVTKP RAEMDVRNAI
VLFSLSAAGV SQELAISRRQ GRVPGNLMGS YRSVEVEAKK EGGSRPGGPG GIRSRLKPID
ADTIDIYARA VFPAAFAAVN IIYWAAYTM
