GBRD_RAT
ID GBRD_RAT Reviewed; 449 AA.
AC P18506;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 2.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Gamma-aminobutyric acid receptor subunit delta;
DE AltName: Full=GABA(A) receptor subunit delta;
DE Flags: Precursor;
GN Name=Gabrd;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain;
RX PubMed=2561970; DOI=10.1016/0896-6273(89)90257-2;
RA Shivers B.D., Killisch I., Sprengel R., Sontheimer H., Koehler M.,
RA Schofield P.R., Seeburg P.H.;
RT "Two novel GABAA receptor subunits exist in distinct neuronal
RT subpopulations.";
RL Neuron 3:327-337(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain;
RX PubMed=1690000; DOI=10.1016/0006-291x(90)91747-g;
RA Zhao Z.Y., Joho R.H.;
RT "Isolation of distantly related members in a multigene family using the
RT polymerase chain reaction technique.";
RL Biochem. Biophys. Res. Commun. 167:174-182(1990).
RN [3]
RP ERRATUM OF PUBMED:1690000.
RA Zhao Z.Y., Joho R.H.;
RL Biochem. Biophys. Res. Commun. 168:887-887(1990).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE OF 1-22.
RC STRAIN=Sprague-Dawley; TISSUE=Testis;
RX PubMed=8195163; DOI=10.1016/s0021-9258(17)36601-2;
RA Motejlek K., Hauselmann R., Leitgeb S., Luescher B.;
RT "BSF1, a novel brain-specific DNA-binding protein recognizing a tandemly
RT repeated purine DNA element in the GABAA receptor delta subunit gene.";
RL J. Biol. Chem. 269:15265-15273(1994).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-390, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate
CC brain, mediates neuronal inhibition by binding to the
CC GABA/benzodiazepine receptor and opening an integral chloride channel.
CC -!- SUBUNIT: Generally pentameric. There are five types of GABA(A) receptor
CC chains: alpha, beta, gamma, delta, and rho.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane
CC protein. Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRD sub-
CC subfamily. {ECO:0000305}.
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DR EMBL; L08496; AAC42035.1; -; Genomic_DNA.
DR EMBL; BC087714; AAH87714.1; -; mRNA.
DR EMBL; M35162; AAA41182.1; -; mRNA.
DR PIR; A34625; A34625.
DR RefSeq; NP_058985.1; NM_017289.1.
DR AlphaFoldDB; P18506; -.
DR SMR; P18506; -.
DR ComplexPortal; CPX-280; GABA-A receptor, alpha-4/beta-3/delta.
DR ComplexPortal; CPX-406; GABA-A receptor, alpha-6/beta-3/delta.
DR ComplexPortal; CPX-407; GABA-A receptor, alpha-6/beta-2/delta.
DR ComplexPortal; CPX-408; GABA-A receptor, alpha-4/beta-2/delta.
DR CORUM; P18506; -.
DR IntAct; P18506; 1.
DR STRING; 10116.ENSRNOP00000022246; -.
DR BindingDB; P18506; -.
DR ChEMBL; CHEMBL4296050; -.
DR ChEMBL; CHEMBL4296053; -.
DR ChEMBL; CHEMBL4296056; -.
DR ChEMBL; CHEMBL4296061; -.
DR DrugCentral; P18506; -.
DR GlyGen; P18506; 2 sites.
DR iPTMnet; P18506; -.
DR PhosphoSitePlus; P18506; -.
DR PaxDb; P18506; -.
DR ABCD; P18506; 1 sequenced antibody.
DR Ensembl; ENSRNOT00000022246; ENSRNOP00000022246; ENSRNOG00000016385.
DR GeneID; 29689; -.
DR KEGG; rno:29689; -.
DR CTD; 2563; -.
DR RGD; 61901; Gabrd.
DR eggNOG; KOG3643; Eukaryota.
DR GeneTree; ENSGT00940000160122; -.
DR HOGENOM; CLU_010920_0_1_1; -.
DR InParanoid; P18506; -.
DR OMA; YRCVEME; -.
DR OrthoDB; 480926at2759; -.
DR PhylomeDB; P18506; -.
DR TreeFam; TF315453; -.
DR PRO; PR:P18506; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000016385; Expressed in frontal cortex and 4 other tissues.
DR Genevisible; P18506; RN.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0030424; C:axon; ISO:RGD.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0030425; C:dendrite; ISO:RGD.
DR GO; GO:1902711; C:GABA-A receptor complex; IPI:ComplexPortal.
DR GO; GO:0098982; C:GABA-ergic synapse; IDA:SynGO.
DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0099055; C:integral component of postsynaptic membrane; IDA:SynGO.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0043025; C:neuronal cell body; ISO:RGD.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0004890; F:GABA-A receptor activity; IDA:RGD.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; ISO:RGD.
DR GO; GO:0007268; P:chemical synaptic transmission; IDA:RGD.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.58.390; -; 1.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR008098; GABAAd_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR PANTHER; PTHR18945:SF34; PTHR18945:SF34; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR01722; GABAARDELTA.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Chloride; Chloride channel; Disulfide bond; Glycoprotein;
KW Ion channel; Ion transport; Membrane; Phosphoprotein;
KW Postsynaptic cell membrane; Reference proteome; Signal; Synapse;
KW Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1..16
FT CHAIN 17..449
FT /note="Gamma-aminobutyric acid receptor subunit delta"
FT /id="PRO_0000000470"
FT TOPO_DOM 17..248
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 249..271
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TRANSMEM 275..297
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TRANSMEM 309..331
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 332..426
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 427..449
FT /note="Helical"
FT /evidence="ECO:0000305"
FT MOD_RES 390
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 106
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 164..178
FT /evidence="ECO:0000250"
SQ SEQUENCE 449 AA; 50566 MW; 64BDBCDEEB2C70AF CRC64;
MDVLGWLLLP LLLLCTQPHH GARAMNDIGD YVGSNLEISW LPNLDGLMEG YARNFRPGIG
GPPVNVALAL EVASIDHISE ANMEYTMTVF LHQSWRDSRL SYNHTNETLG LDSRFVDKLW
LPDTFIVNAK SAWFHDVTVE NKLIRLQPDG VILYSIRITS TVACDMDLAK YPMDEQECML
DLESYGYSSE DIVYYWSENQ EQIHGLDRLQ LAQFTITSYR FTTELMNFKS AGQFPRLSLH
FQLRRNRGVY IIQSYMPSVL LVAMSWVSFW ISQAAVPARV SLGITTVLTM TTLMVSARSS
LPRASAIKAL DVYFWICYVF VFAALVEYAF AHFNADYRKK RKAKVKVTKP RAEMDVRNAI
VLFSLSAAGV SQELAISRRQ GRVPGNLMGS YRSVEVEAKK EGGSRPGGPG GIRSRLKPID
ADTIDIYARA VFPAAFAAVN IIYWAAYTM
