GBRE_RAT
ID GBRE_RAT Reviewed; 506 AA.
AC Q9ES14; O55209;
DT 04-MAY-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Gamma-aminobutyric acid receptor subunit epsilon;
DE AltName: Full=GABA(A) receptor subunit epsilon;
DE Flags: Precursor;
GN Name=Gabre;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11122342; DOI=10.1111/j.1460-9568.2000.01343.x;
RA Moragues N., Ciofi P., Lafon P., Odessa M.F., Tramu G., Garret M.;
RT "cDNA cloning and expression of a gamma-aminobutyric acid A receptor
RT epsilon-subunit in rat brain.";
RL Eur. J. Neurosci. 12:4318-4330(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 123-506.
RA Hanna M.C., Hales T.G., Kirkness E.F.;
RT "Alternative transcripts of a gene encoding the GABA-A receptor epsilon
RT subunit on chromosome Xq28.";
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate
CC brain, mediates neuronal inhibition by binding to the
CC GABA/benzodiazepine receptor and opening an integral chloride channel.
CC {ECO:0000250}.
CC -!- SUBUNIT: Generally pentameric. Associates with alpha and beta subunits
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRE sub-
CC subfamily. {ECO:0000305}.
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DR EMBL; AF255612; AAG17631.1; -; mRNA.
DR EMBL; U92284; AAB93879.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9ES14; -.
DR SMR; Q9ES14; -.
DR STRING; 10116.ENSRNOP00000022431; -.
DR ChEMBL; CHEMBL1907607; -.
DR DrugCentral; Q9ES14; -.
DR GlyGen; Q9ES14; 2 sites.
DR PaxDb; Q9ES14; -.
DR ABCD; Q9ES14; 1 sequenced antibody.
DR RGD; 68320; Gabre.
DR eggNOG; KOG3642; Eukaryota.
DR InParanoid; Q9ES14; -.
DR PRO; PR:Q9ES14; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0032590; C:dendrite membrane; IBA:GO_Central.
DR GO; GO:1902711; C:GABA-A receptor complex; ISO:RGD.
DR GO; GO:0098982; C:GABA-ergic synapse; IDA:SynGO.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0099055; C:integral component of postsynaptic membrane; IDA:SynGO.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0098794; C:postsynapse; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0004890; F:GABA-A receptor activity; IDA:RGD.
DR GO; GO:0022851; F:GABA-gated chloride ion channel activity; ISO:RGD.
DR GO; GO:0005237; F:inhibitory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IDA:SynGO.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR GO; GO:0006821; P:chloride transport; TAS:RGD.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IDA:RGD.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:2001226; P:negative regulation of chloride transport; ISO:RGD.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0060078; P:regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEP:RGD.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR GO; GO:0051932; P:synaptic transmission, GABAergic; IBA:GO_Central.
DR Gene3D; 1.20.58.390; -; 1.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR008099; GABAAe_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR01723; GABAAREPSLON.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Chloride; Chloride channel; Disulfide bond; Glycoprotein;
KW Ion channel; Ion transport; Membrane; Postsynaptic cell membrane;
KW Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..506
FT /note="Gamma-aminobutyric acid receptor subunit epsilon"
FT /id="PRO_0000000472"
FT TOPO_DOM 23..254
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 366..485
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 486..506
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 32..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 135
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 253
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 196..210
FT /evidence="ECO:0000250"
FT CONFLICT 133
FT /note="R -> C (in Ref. 2; AAB93879)"
FT /evidence="ECO:0000305"
FT CONFLICT 467
FT /note="N -> S (in Ref. 2; AAB93879)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 506 AA; 59219 MW; 8C2FBECF10686E57 CRC64;
MLPKVLLMLL NMFLALQWRV GPHIKLENKP PAQDKVVFGP QPQPSGKKLP ARETELTADH
TTERPRGKLT RASQILNTIL SNYDHKLRPS IGEKPTVVTV KVFVNSLGPI SILDMEYSID
IIFYQTWYDE RLRYNDTFET LILHGNVVSQ LWIPDTFFRN SKRTQEYDIT IPNQMALIHK
DGKVLYTVRM TIDARCSLHM LNFPMDSHSC PLSFSSFSYD EHEMIYKWEN FKLKIDAKNT
WKLLEFDFTG VNNKTEIIST PVGDFMVMTF FFNVSRRFGF IVFQNYIPSS VTTMLSWVSF
WIKIEAAAAR ASVGVSSVLT MATLGTFSRK NFPRVSYLTA LDFYIAICFV LCFCTLLEFT
VLNFLTYNNI ERQASPKFYQ FPTNSRANAR TRARARTRAR ARARARQQQE VFVCEIVTYE
ENAEEGYQWS PRSRRPQCPW RRCGRSYVCF RVLRKYFCMV PGCEGNNWQR GRICIHVYRL
DNYSRVLFPI TFFFFNVVYW VICLNL
