GBRG4_CHICK
ID GBRG4_CHICK Reviewed; 457 AA.
AC P34904;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Gamma-aminobutyric acid receptor subunit gamma-4;
DE AltName: Full=GABA(A) receptor subunit gamma-4;
DE Flags: Precursor;
GN Name=GABRG4;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8397108; DOI=10.1016/0014-5793(93)80339-v;
RA Harvey R.J., Kim H.-C., Darlison M.G.;
RT "Molecular cloning reveals the existence of a fourth gamma subunit of the
RT vertebrate brain GABAA receptor.";
RL FEBS Lett. 331:211-216(1993).
CC -!- FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate
CC brain, mediates neuronal inhibition by binding to the
CC GABA/benzodiazepine receptor and opening an integral chloride channel.
CC -!- SUBUNIT: Generally pentameric. There are five types of GABA(A) receptor
CC chains: alpha, beta, gamma, delta, and rho.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane
CC protein. Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Abundant in several brain regions, including the
CC ectostriatum, nucleus rotundus and hyperstriatum ventrale.
CC -!- MISCELLANEOUS: This subunit carries the benzodiazepine binding site.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG4 sub-
CC subfamily. {ECO:0000305}.
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DR EMBL; X73533; CAA51939.1; -; mRNA.
DR PIR; S38296; S38296.
DR RefSeq; NP_990576.1; NM_205245.1.
DR AlphaFoldDB; P34904; -.
DR SMR; P34904; -.
DR STRING; 9031.ENSGALP00000011763; -.
DR PaxDb; P34904; -.
DR Ensembl; ENSGALT00000011777; ENSGALP00000011763; ENSGALG00000020292.
DR GeneID; 396173; -.
DR KEGG; gga:396173; -.
DR CTD; 2564; -.
DR VEuPathDB; HostDB:geneid_396173; -.
DR eggNOG; KOG3642; Eukaryota.
DR GeneTree; ENSGT00940000161201; -.
DR HOGENOM; CLU_010920_2_0_1; -.
DR InParanoid; P34904; -.
DR OMA; IYRWRRY; -.
DR OrthoDB; 1057372at2759; -.
DR PhylomeDB; P34904; -.
DR PRO; PR:P34904; -.
DR Proteomes; UP000000539; Chromosome 4.
DR Bgee; ENSGALG00000020292; Expressed in cerebellum.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0032590; C:dendrite membrane; IBA:GO_Central.
DR GO; GO:1902711; C:GABA-A receptor complex; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0098794; C:postsynapse; IBA:GO_Central.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
DR GO; GO:0022851; F:GABA-gated chloride ion channel activity; IBA:GO_Central.
DR GO; GO:0005237; F:inhibitory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:2001226; P:negative regulation of chloride transport; IEA:Ensembl.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0060078; P:regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR GO; GO:0051932; P:synaptic transmission, GABAergic; IBA:GO_Central.
DR Gene3D; 1.20.58.390; -; 1.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR005437; GABRG-1/4.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR01620; GABAARGAMMA.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Chloride; Chloride channel; Disulfide bond; Glycoprotein;
KW Ion channel; Ion transport; Membrane; Postsynaptic cell membrane;
KW Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..457
FT /note="Gamma-aminobutyric acid receptor subunit gamma-4"
FT /id="PRO_0000000484"
FT TOPO_DOM 22..256
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 257..279
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TRANSMEM 283..305
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TRANSMEM 317..339
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 340..433
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 434..457
FT /note="Helical"
FT /evidence="ECO:0000305"
FT CARBOHYD 35
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 112
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 230
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 173..187
FT /evidence="ECO:0000250"
SQ SEQUENCE 457 AA; 53183 MW; 695B835D9CA46547 CRC64;
MPAMVLLLCL ALGPALRSAR CESTEEYDYD YLSINKTWVL TPKAQETDAT QILNSLLKNY
DNKLRPDIGI KPTFIDVDIY VNSIGPVSVI QMEYTIDIFF AQTWYDRRLR FNSTLKALTL
NTNMVSRIWI PDTFFRNSKR ADSHWITTPN QLLRIWNDGK VLYTLRLTIE AECLLQLQNF
PMDTHSCPLV FSSYGYPREE IVYRWRRYSI EVSDQRTWRL YQFDFTGLRN TSEVLRTGAG
EYMVMTVSFD LSRRMGYFAI QTYIPCILTV VLSWVSFWIK RDSTPARTSL GITTVLTMTT
LSTISRKHLP RVSYITAMDL FVSVCFIFVF AALMEYATLN YLVGNKKPLE HSSRKARLPP
AGAQVMPSFT AINININNIM HWPPEIEEDE DDDPGSPCLE GKECERFFCC IEDCQTGMWR
EGRVRIHISR LDSYSRVFFP TAFLLFNIVY WIAYLYL
