GBRL1_XENTR
ID GBRL1_XENTR Reviewed; 117 AA.
AC Q5BIZ2;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Gamma-aminobutyric acid receptor-associated protein-like 1;
DE AltName: Full=GABA(A) receptor-associated protein-like 1;
DE Flags: Precursor;
GN Name=gabarapl1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Ubiquitin-like modifier that increases cell-surface
CC expression of kappa-type opioid receptor through facilitating
CC anterograde intracellular trafficking of the receptor. Involved in
CC formation of autophagosomal vacuoles. While LC3s are involved in
CC elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is
CC essential for a later stage in autophagosome maturation.
CC {ECO:0000250|UniProtKB:Q9H0R8}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome
CC {ECO:0000250|UniProtKB:Q9H0R8}. Cytoplasmic vesicle membrane
CC {ECO:0000250|UniProtKB:Q9H0R8}; Lipid-anchor
CC {ECO:0000250|UniProtKB:Q9H0R8}. Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q0VGK0}. Endoplasmic reticulum
CC {ECO:0000250|UniProtKB:Q0VGK0}. Golgi apparatus
CC {ECO:0000250|UniProtKB:Q0VGK0}.
CC -!- PTM: The precursor molecule is cleaved by ATG4 (atg4a, atg4b, atg4c or
CC atg4d) to expose the glycine at the C-terminus and form the cytosolic
CC form, gabarapl1-I. The processed form is then activated by apg7l/atg7,
CC transferred to atg3 and conjugated to phosphatidylethanolamine (PE)
CC phospholipid to form the membrane-bound form, gabarapl1-II. During non-
CC canonical autophagy, the processed form is conjugated to
CC phosphatidylserine (PS) phospholipid. Atg4 proteins also mediate the
CC delipidation of PE-conjugated forms required for gabarapl1 recycling
CC when autophagosomes fuse with lysosomes. In addition, some atg4
CC proteins mediate delipidation of ATG8 proteins conjugated to PS during
CC non-canonical autophagy. {ECO:0000250|UniProtKB:Q9H0R8}.
CC -!- SIMILARITY: Belongs to the ATG8 family. {ECO:0000305}.
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DR EMBL; BC091701; AAH91701.1; -; mRNA.
DR RefSeq; NP_001025652.1; NM_001030481.1.
DR AlphaFoldDB; Q5BIZ2; -.
DR BMRB; Q5BIZ2; -.
DR SMR; Q5BIZ2; -.
DR STRING; 8364.ENSXETP00000031780; -.
DR PaxDb; Q5BIZ2; -.
DR DNASU; 595040; -.
DR GeneID; 595040; -.
DR KEGG; xtr:595040; -.
DR CTD; 23710; -.
DR Xenbase; XB-GENE-946688; gabarapl1.
DR eggNOG; KOG1654; Eukaryota.
DR HOGENOM; CLU_119276_0_0_1; -.
DR InParanoid; Q5BIZ2; -.
DR OrthoDB; 1508198at2759; -.
DR PhylomeDB; Q5BIZ2; -.
DR Reactome; R-XTR-1632852; Macroautophagy.
DR Proteomes; UP000008143; Chromosome 7.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000016242; Expressed in brain and 16 other tissues.
DR GO; GO:0005776; C:autophagosome; IBA:GO_Central.
DR GO; GO:0000421; C:autophagosome membrane; IBA:GO_Central.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0050811; F:GABA receptor binding; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR GO; GO:0000422; P:autophagy of mitochondrion; IBA:GO_Central.
DR GO; GO:0006995; P:cellular response to nitrogen starvation; IBA:GO_Central.
DR GO; GO:0016236; P:macroautophagy; IBA:GO_Central.
DR InterPro; IPR004241; Atg8-like.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR10969; PTHR10969; 1.
DR Pfam; PF02991; ATG8; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
PE 3: Inferred from homology;
KW Autophagy; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton;
KW Endoplasmic reticulum; Golgi apparatus; Lipoprotein; Membrane; Microtubule;
KW Reference proteome.
FT CHAIN 1..116
FT /note="Gamma-aminobutyric acid receptor-associated protein-
FT like 1"
FT /id="PRO_0000438281"
FT PROPEP 117
FT /note="Removed in mature form"
FT /id="PRO_0000342412"
FT SITE 116..117
FT /note="Cleavage; by ATG4B"
FT /evidence="ECO:0000250|UniProtKB:Q9H0R8"
FT LIPID 116
FT /note="Phosphatidylethanolamine amidated glycine;
FT alternate"
FT /evidence="ECO:0000250|UniProtKB:Q9H0R8"
FT LIPID 116
FT /note="Phosphatidylserine amidated glycine; alternate"
FT /evidence="ECO:0000250|UniProtKB:Q9H0R8"
SQ SEQUENCE 117 AA; 14044 MW; 7F56E345255F564B CRC64;
MKFQYKEDHP FEYRKKEGEK IRKKYPDRVP VIVEKAPKAR VPDLDKRKYL VPSDLTVGQF
YFLIRKRIHL RPEDALFFFV NNTIPPTSAT MGQLYEDNHE EDYFLYVAYS DESVYGK