GBRR1_MOUSE
ID GBRR1_MOUSE Reviewed; 480 AA.
AC P56475; A3KG51;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Gamma-aminobutyric acid receptor subunit rho-1;
DE AltName: Full=GABA(A) receptor subunit rho-1;
DE AltName: Full=GABA(C) receptor;
DE Flags: Precursor;
GN Name=Gabrr1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Retina;
RA Greka A., Koolen J.A., Lipton S.A., Zhang D.;
RT "Molecular cloning of GABA rho subunits in the mouse retina.";
RL Abstr. - Soc. Neurosci. 23:1262-1262(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate
CC brain, mediates neuronal inhibition by binding to the
CC GABA/benzodiazepine receptor and opening an integral chloride channel.
CC Rho-1 GABA receptor could play a role in retinal neurotransmission (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Generally pentameric. There are five types of GABA(A) receptor
CC chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR1 sub-
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB81964.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAM45896.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF024620; AAB81964.1; ALT_INIT; mRNA.
DR EMBL; AL670464; CAM45896.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS18021.2; -.
DR RefSeq; NP_032101.3; NM_008075.2.
DR AlphaFoldDB; P56475; -.
DR SMR; P56475; -.
DR STRING; 10090.ENSMUSP00000029947; -.
DR GlyGen; P56475; 3 sites.
DR iPTMnet; P56475; -.
DR PhosphoSitePlus; P56475; -.
DR PaxDb; P56475; -.
DR PRIDE; P56475; -.
DR ProteomicsDB; 268854; -.
DR Antibodypedia; 31856; 234 antibodies from 24 providers.
DR DNASU; 14408; -.
DR Ensembl; ENSMUST00000029947; ENSMUSP00000029947; ENSMUSG00000028280.
DR GeneID; 14408; -.
DR KEGG; mmu:14408; -.
DR UCSC; uc008sfr.2; mouse.
DR CTD; 2569; -.
DR MGI; MGI:95625; Gabrr1.
DR VEuPathDB; HostDB:ENSMUSG00000028280; -.
DR eggNOG; KOG3643; Eukaryota.
DR GeneTree; ENSGT00940000158591; -.
DR HOGENOM; CLU_010920_0_1_1; -.
DR InParanoid; P56475; -.
DR OMA; SSYVSMK; -.
DR OrthoDB; 640805at2759; -.
DR PhylomeDB; P56475; -.
DR TreeFam; TF315453; -.
DR Reactome; R-MMU-977443; GABA receptor activation.
DR BioGRID-ORCS; 14408; 2 hits in 70 CRISPR screens.
DR PRO; PR:P56475; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; P56475; protein.
DR Bgee; ENSMUSG00000028280; Expressed in retinal neural layer and 3 other tissues.
DR Genevisible; P56475; MM.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:1902711; C:GABA-A receptor complex; IBA:GO_Central.
DR GO; GO:0098982; C:GABA-ergic synapse; IDA:SynGO.
DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0016917; F:GABA receptor activity; ISO:MGI.
DR GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0099507; F:ligand-gated ion channel activity involved in regulation of presynaptic membrane potential; IDA:SynGO.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0019904; F:protein domain specific binding; ISO:MGI.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IDA:SynGO.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.58.390; -; 1.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR008058; GABAAa_rho1_rcpt.
DR InterPro; IPR008057; GABAAa_rho_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR01670; GABAARRHO.
DR PRINTS; PR01671; GABAARRHO1.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Chloride; Chloride channel; Disulfide bond; Glycoprotein;
KW Ion channel; Ion transport; Membrane; Postsynaptic cell membrane;
KW Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..480
FT /note="Gamma-aminobutyric acid receptor subunit rho-1"
FT /id="PRO_0000000486"
FT TOPO_DOM 22..282
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 283..306
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TRANSMEM 310..332
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TRANSMEM 344..366
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 367..458
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 459..480
FT /note="Helical"
FT /evidence="ECO:0000305"
FT REGION 29..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 141
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 235
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 275
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 199..213
FT /evidence="ECO:0000250"
FT CONFLICT 414
FT /note="M -> L (in Ref. 1; AAB81964)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 480 AA; 55488 MW; BF071780C464FCCA CRC64;
MLAVQNMKFG IFLLWWGWVL AAESTAHWPG REVHEPSRKG SRPQRQRRGA HDDAHKQGSP
ILRRSSDITK SPLTKSEQLL RIDDHDFSMR PGFGGPAIPV GVDVQVESLD SISEVDMDFT
MTLYLRHYWK DERLSFPSSN NLSMTFDGRL VKKIWVPDMF FVHSKRSFIH DTTTDNVMLR
VQPDGKVLYS LRVTVTAMCN MDFSRFPLDT QTCSLEIESY AYTEDDLMLY WKKGNDSLKT
DERISLSQFL IQEFHTTTKL AFYSSTGWYN RLYINFTLRR HIFFFLLQTY FPATLMVMLS
WVSFWIDRRA VPARVPLGIT TVLTMSTIIT GVNASMPRVS YIKAVDIYLW VSFVFVFLSV
LEYAAVNYLT TVQERKERKL REKISCTCGL PQPRGVMLDS SYSDGEVNDL GGYMPENGEK
PDRMMVQLTL ASERGSPQRK GQRGSYVSMR INTHAIDKYS RIIFPAAYIL FNLIYWSIFS
