GBRT_MOUSE
ID GBRT_MOUSE Reviewed; 638 AA.
AC Q9JLF1;
DT 04-MAY-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Gamma-aminobutyric acid receptor subunit theta;
DE AltName: Full=GABA(A) receptor subunit theta;
DE Flags: Precursor;
GN Name=Gabrq;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10804200; DOI=10.1523/jneurosci.20-10-03588.2000;
RA Sinkkonen S.T., Hanna M.C., Kirkness E.F., Korpi E.R.;
RT "GABAA receptor epsilon and theta subunits display unusual structural
RT variation between species and are enriched in the rat locus ceruleus.";
RL J. Neurosci. 20:3588-3595(2000).
CC -!- FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate
CC brain, mediates neuronal inhibition by binding to the
CC GABA/benzodiazepine receptor and opening an integral chloride channel.
CC -!- SUBUNIT: Generally pentameric. This subunit coassembles with alpha-2,
CC beta-1 and gamma-1.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane
CC protein. Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRQ sub-
CC subfamily. {ECO:0000305}.
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DR EMBL; AF189260; AAF70381.1; -; mRNA.
DR CCDS; CCDS30188.1; -.
DR RefSeq; NP_065234.1; NM_020488.2.
DR RefSeq; XP_006528236.1; XM_006528173.1.
DR AlphaFoldDB; Q9JLF1; -.
DR SMR; Q9JLF1; -.
DR STRING; 10090.ENSMUSP00000033711; -.
DR ChEMBL; CHEMBL2094133; -.
DR DrugCentral; Q9JLF1; -.
DR GlyGen; Q9JLF1; 1 site.
DR PhosphoSitePlus; Q9JLF1; -.
DR PaxDb; Q9JLF1; -.
DR PRIDE; Q9JLF1; -.
DR ProteomicsDB; 272942; -.
DR Antibodypedia; 73628; 109 antibodies from 21 providers.
DR DNASU; 57249; -.
DR Ensembl; ENSMUST00000033711; ENSMUSP00000033711; ENSMUSG00000031344.
DR GeneID; 57249; -.
DR KEGG; mmu:57249; -.
DR UCSC; uc009tkq.2; mouse.
DR CTD; 55879; -.
DR MGI; MGI:1888498; Gabrq.
DR VEuPathDB; HostDB:ENSMUSG00000031344; -.
DR eggNOG; KOG3643; Eukaryota.
DR GeneTree; ENSGT00940000162167; -.
DR InParanoid; Q9JLF1; -.
DR OMA; IVLYWEG; -.
DR OrthoDB; 480926at2759; -.
DR PhylomeDB; Q9JLF1; -.
DR TreeFam; TF315453; -.
DR Reactome; R-MMU-977443; GABA receptor activation.
DR BioGRID-ORCS; 57249; 4 hits in 75 CRISPR screens.
DR PRO; PR:Q9JLF1; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9JLF1; protein.
DR Bgee; ENSMUSG00000031344; Expressed in secondary oocyte and 24 other tissues.
DR ExpressionAtlas; Q9JLF1; baseline and differential.
DR Genevisible; Q9JLF1; MM.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:1902711; C:GABA-A receptor complex; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:MGI.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; ISO:MGI.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0004890; F:GABA-A receptor activity; ISS:MGI.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR GO; GO:0006821; P:chloride transport; ISS:MGI.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; ISS:MGI.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.58.390; -; 1.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR008101; GABAAt_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR01725; GABAARTHETA.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Chloride; Chloride channel; Disulfide bond; Glycoprotein;
KW Ion channel; Ion transport; Membrane; Postsynaptic cell membrane;
KW Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..638
FT /note="Gamma-aminobutyric acid receptor subunit theta"
FT /id="PRO_0000000496"
FT TOPO_DOM 22..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 618..638
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 491..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 183..197
FT /evidence="ECO:0000250"
SQ SEQUENCE 638 AA; 72799 MW; 4E2C4FA02E9BF8A3 CRC64;
MGIRGMLRAA ALLLLIRTWL AESNGPSPTP KFHFELSSST PEVILDLFNC KNCANEAVVQ
KILDRVLSTY DVRLRPNFGG APVPVSVSIY VSSIEQISEI NMDYTITMFL HQTWKDTRLA
YYETNLNLTL DYRMHEKLWV PDCYFVNSKD AFVHDVTVEN RVFQLHPDGT VRYGIRLTTT
AACSLDLQKF PMDKQSCKLE VESYGYTVED IVLSWEDDNA IHITDGLHIP QYTYLGRTIT
SKEVYFYTGS YMRLIVKFQV QREVRSYLVQ VYWPTVLTTI LSWISFWMNY DSSAARVTIG
LTSILVLTTI DSHMRDKLPH ISCIKAIDIY ILVCLFFVFL SLLEYVYINY LFFSQVPRRN
HRRCRKPRRV VARYRYQEVV VANVQDGLIN VEDRVEDRAG PLPDSPMQAH LASQESLGSL
VFTSEQAQLA TSESLSLLSS ASSQTQLATG ESLSDLPSTS EQTVPECTIH FHGFLTNDSI
IPIKIHSRSD ACDDEDSEES LSSEESHGHG SSHTGRLKLQ ISQRCVQEAS WDLDKIEILQ
DDISITSSWL GLDEQCKGDA DSIWSLTDEE LMACDQEKDS SSESEENCSP SPGCSFNEGF
SFQLFKPNRV PKVDRWSRFL FPLSFGLFNV VYWLYHVY
