GBS76_DROME
ID GBS76_DROME Reviewed; 681 AA.
AC Q9VVY3; C3KGL1; Q8T0I8;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Glycogen-binding subunit 76A;
DE AltName: Full=CBM21 domain-containing protein CG9619;
GN Name=Gbs-76A; ORFNames=CG9619;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RA Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 245-681.
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-545; SER-547 AND SER-549, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=17372656; DOI=10.1039/b617545g;
RA Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA Eng J.K., Aebersold R., Tao W.A.;
RT "An integrated chemical, mass spectrometric and computational strategy for
RT (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT Kc167 cells.";
RL Mol. Biosyst. 3:275-286(2007).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL39375.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE014296; AAF49172.1; -; Genomic_DNA.
DR EMBL; BT082076; ACP31593.1; -; mRNA.
DR EMBL; AY069230; AAL39375.1; ALT_INIT; mRNA.
DR RefSeq; NP_001262043.1; NM_001275114.1.
DR RefSeq; NP_001262044.1; NM_001275115.1.
DR RefSeq; NP_001287118.1; NM_001300189.1.
DR RefSeq; NP_649104.1; NM_140847.2.
DR AlphaFoldDB; Q9VVY3; -.
DR SMR; Q9VVY3; -.
DR BioGRID; 65378; 4.
DR IntAct; Q9VVY3; 5.
DR STRING; 7227.FBpp0304465; -.
DR CAZy; CBM21; Carbohydrate-Binding Module Family 21.
DR iPTMnet; Q9VVY3; -.
DR PaxDb; Q9VVY3; -.
DR DNASU; 40102; -.
DR EnsemblMetazoa; FBtr0075014; FBpp0074781; FBgn0036862.
DR EnsemblMetazoa; FBtr0331425; FBpp0303842; FBgn0036862.
DR EnsemblMetazoa; FBtr0332155; FBpp0304465; FBgn0036862.
DR EnsemblMetazoa; FBtr0345390; FBpp0311540; FBgn0036862.
DR GeneID; 40102; -.
DR KEGG; dme:Dmel_CG9619; -.
DR UCSC; CG9619-RA; d. melanogaster.
DR CTD; 40102; -.
DR FlyBase; FBgn0036862; Gbs-76A.
DR VEuPathDB; VectorBase:FBgn0036862; -.
DR eggNOG; KOG3986; Eukaryota.
DR HOGENOM; CLU_016437_0_0_1; -.
DR InParanoid; Q9VVY3; -.
DR OMA; NAHESEQ; -.
DR OrthoDB; 1232750at2759; -.
DR PhylomeDB; Q9VVY3; -.
DR BioGRID-ORCS; 40102; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 40102; -.
DR PRO; PR:Q9VVY3; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0036862; Expressed in mouthpart and 13 other tissues.
DR ExpressionAtlas; Q9VVY3; baseline and differential.
DR Genevisible; Q9VVY3; DM.
DR GO; GO:0000164; C:protein phosphatase type 1 complex; IBA:GO_Central.
DR GO; GO:2001069; F:glycogen binding; IBA:GO_Central.
DR GO; GO:0008157; F:protein phosphatase 1 binding; IPI:FlyBase.
DR GO; GO:0005979; P:regulation of glycogen biosynthetic process; IBA:GO_Central.
DR Gene3D; 2.60.40.2440; -; 1.
DR InterPro; IPR005036; CBM21_dom.
DR InterPro; IPR038175; CBM21_dom_sf.
DR Pfam; PF03370; CBM_21; 1.
DR PROSITE; PS51159; CBM21; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..681
FT /note="Glycogen-binding subunit 76A"
FT /id="PRO_0000372644"
FT DOMAIN 525..632
FT /note="CBM21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00491"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..251
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..339
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..381
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 545
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT MOD_RES 547
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT MOD_RES 549
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:17372656"
FT CONFLICT 669
FT /note="S -> G (in Ref. 4; AAL39375)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 681 AA; 73967 MW; 89DD9AB1F88101A9 CRC64;
MNDPGDIPLT HTSTPDSRPP CSIISIIPTI GMSSCRGRAE AFARSLSSKL RTLGSQTTEE
GEGNAEDEPI INGTSTNTWV NSHDSEQTVT DLQPLRHESD SFFDFDCELE SPGSPVDECE
YLRLIETASN TPHNSTAESG YACASMASSH SSSNDGPYFD ASASTSTAAA AQDQTLPASE
HKEYVNTLQL NGKHGLANGV QEEQPAFQDD VQEDEAFLQA QILNELQKHS NSLTEVEQTK
PEEGKLTNGH LEKVEELELK DVLEVAGTTN RAPKVIAAPQ EVEAFADRSQ EQSPNDRVQK
ESSQERVPEG TPFEGVQGES PSDRVQTDAS DERVQEEISN DTVQVESNHK SATESISTEV
TTLERSPEES RNDELSPDSG VDETDKSASN LTVDVDLAQI EQAKQDATEA VEKSGAPSRG
TTVDTTDDED DCRPQRIRRC SSLKTGKTPP GTPGRKKIVR FADVLGLDLA DVKTFLDEIP
TIPKSAFEDL EILESEPPLQ LGPKSDKLLM PLFQQPGGLP KFLDAVREKQ VSLENAAVTD
NINQTISGSV RVRNLDFHKS VHIRYSLDGW RSYADLQANY VENSCDGFSD IFTFVLFGNS
LHVGQRLEFA VRFQCKGQQF WDNNYGANYC FQCLPSSTHT AGGSTASPPS VATGAVSTGH
SASLVGLLSP TAGDAWCSSF Y
