ID   GBT_DESHY               Reviewed;         496 AA.
AC   Q24SP9;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Probable glycine betaine transporter {ECO:0000303|PubMed:25313086};
GN   OrderedLocusNames=DSY3154 {ECO:0000312|EMBL:BAE84943.1};
OS   Desulfitobacterium hafniense (strain Y51).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Desulfitobacteriaceae;
OC   Desulfitobacterium.
OX   NCBI_TaxID=138119;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Y51;
RX   PubMed=16513756; DOI=10.1128/jb.188.6.2262-2274.2006;
RA   Nonaka H., Keresztes G., Shinoda Y., Ikenaga Y., Abe M., Naito K.,
RA   Inatomi K., Furukawa K., Inui M., Yukawa H.;
RT   "Complete genome sequence of the dehalorespiring bacterium
RT   Desulfitobacterium hafniense Y51 and comparison with Dehalococcoides
RT   ethenogenes 195.";
RL   J. Bacteriol. 188:2262-2274(2006).
RN   [2]
RP   FUNCTION, AND INDUCTION.
RC   STRAIN=Y51;
RX   PubMed=25313086; DOI=10.1073/pnas.1409642111;
RA   Ticak T., Kountz D.J., Girosky K.E., Krzycki J.A., Ferguson D.J. Jr.;
RT   "A nonpyrrolysine member of the widely distributed trimethylamine
RT   methyltransferase family is a glycine betaine methyltransferase.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:E4668-E4676(2014).
CC   -!- FUNCTION: Probably acts in the uptake of glycine betaine. May function
CC       in the pathway that allows anaerobic methylotrophic growth of
CC       D.hafniense using glycine betaine. {ECO:0000305|PubMed:25313086}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Highly up-regulated during growth on glycine betaine.
CC       {ECO:0000269|PubMed:25313086}.
CC   -!- SIMILARITY: Belongs to the BCCT transporter (TC 2.A.15) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP008230; BAE84943.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q24SP9; -.
DR   SMR; Q24SP9; -.
DR   STRING; 138119.DSY3154; -.
DR   EnsemblBacteria; BAE84943; BAE84943; DSY3154.
DR   KEGG; dsy:DSY3154; -.
DR   eggNOG; COG1292; Bacteria.
DR   HOGENOM; CLU_010118_5_0_9; -.
DR   OMA; RVMSDIN; -.
DR   Proteomes; UP000001946; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0071705; P:nitrogen compound transport; IEA:InterPro.
DR   InterPro; IPR018093; BCCT_CS.
DR   InterPro; IPR000060; BCCT_transptr.
DR   PANTHER; PTHR30047; PTHR30047; 1.
DR   Pfam; PF02028; BCCT; 1.
DR   TIGRFAMs; TIGR00842; bcct; 1.
DR   PROSITE; PS01303; BCCT; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..496
FT                   /note="Probable glycine betaine transporter"
FT                   /id="PRO_0000441380"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        396..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        441..461
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        468..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   496 AA;  54338 MW;  A2CB371D601007E0 CRC64;
     MNMGVDKKQN TVLYISSAIA LLFVLWGVFL PENMANVVNK VFALLTTNFG WLYLLAVAIF
     IIFVFGIAIS RYGKIKLGAD DDKPEFSNFQ WFAMLFGGGM GIGLVFWSVA EPIMHFNSPP
     FGEPGTVEAM QTSMRVVFFH WGIHAWVNFA IAGLALAYFQ FRKGLPFLIS SAFYPLIGDR
     IYGPIGKAID ILAVFATIFG IATSLGLGSS QIATGIQYIW GIPAGPLTIS LVIAVITVIF
     TLATVSGLHK AMQSIANVKV WLSVAFMVFI FYFGGKVFIL NTFTQSLGDY LQNFVGQTFW
     MANESWVGGW TIFYWAWWIA WAPFVGQFVA RVSKGRTIRE FVFAVTLLPV GFSFIWLAIY
     GGAAFNLDQI SGGFIQNAVN ADYTTALFAL LQQMPLYAIT GPLAILLIVT CFVGAADSAT
     YVLAMLTSNG DMDPSKKLRS FWGIMQGAMT IVLIVVGGTA ALKALQTASI ASAFPFMLIM
     LVMCYSILKA LRSDHP