GBX1_MOUSE
ID GBX1_MOUSE Reviewed; 418 AA.
AC P82976; Q8CGW5;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Homeobox protein GBX-1;
DE AltName: Full=Gastrulation and brain-specific homeobox protein 1;
GN Name=Gbx1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6 X C3H;
RX PubMed=12799077; DOI=10.1016/s1567-133x(03)00041-3;
RA Waters S.T., Wilson C.P., Lewandoski M.;
RT "Cloning and embryonic expression analysis of the mouse Gbx1 gene.";
RL Gene Expr. Patterns 3:313-317(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14745958; DOI=10.1002/dvdy.10435;
RA Rhinn M., Lun K., Werner M., Simeone A., Brand M.;
RT "Isolation and expression of the homeobox gene Gbx1 during mouse
RT development.";
RL Dev. Dyn. 229:334-339(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 337-361.
RC STRAIN=C57BL/6J; TISSUE=Spleen;
RX PubMed=1720547; DOI=10.1073/pnas.88.23.10711;
RA Murtha M.T., Leckman J.F., Ruddle F.H.;
RT "Detection of homeobox genes in development and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- TISSUE SPECIFICITY: Expressed in CNS including rhombomeres 3 and 5,
CC optic vesicles, and the medial ganglionic eminence.
CC {ECO:0000269|PubMed:12799077}.
CC -!- DEVELOPMENTAL STAGE: Expressed first during gastrulation and later in a
CC dynamic pattern in the central nervous system.
CC {ECO:0000269|PubMed:12799077}.
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DR EMBL; AF547996; AAO16238.1; -; mRNA.
DR EMBL; AY319256; AAQ19677.1; -; mRNA.
DR EMBL; M81662; AAA63311.1; -; Genomic_DNA.
DR CCDS; CCDS19123.1; -.
DR PIR; D41606; D41606.
DR RefSeq; NP_056554.1; NM_015739.2.
DR AlphaFoldDB; P82976; -.
DR SMR; P82976; -.
DR STRING; 10090.ENSMUSP00000085651; -.
DR PhosphoSitePlus; P82976; -.
DR MaxQB; P82976; -.
DR PaxDb; P82976; -.
DR PRIDE; P82976; -.
DR Antibodypedia; 32984; 123 antibodies from 22 providers.
DR DNASU; 231044; -.
DR Ensembl; ENSMUST00000088311; ENSMUSP00000085651; ENSMUSG00000067724.
DR GeneID; 231044; -.
DR KEGG; mmu:231044; -.
DR UCSC; uc008wrx.1; mouse.
DR CTD; 2636; -.
DR MGI; MGI:95667; Gbx1.
DR VEuPathDB; HostDB:ENSMUSG00000067724; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000154365; -.
DR HOGENOM; CLU_052189_0_0_1; -.
DR InParanoid; P82976; -.
DR OMA; CGPLSQK; -.
DR OrthoDB; 1406210at2759; -.
DR PhylomeDB; P82976; -.
DR TreeFam; TF351530; -.
DR BioGRID-ORCS; 231044; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Gbx1; mouse.
DR PRO; PR:P82976; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; P82976; protein.
DR Bgee; ENSMUSG00000067724; Expressed in pericardio-peritoneal canal and 33 other tissues.
DR Genevisible; P82976; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007628; P:adult walking behavior; IMP:MGI.
DR GO; GO:0048663; P:neuron fate commitment; IMP:MGI.
DR GO; GO:0019230; P:proprioception; IMP:MGI.
DR GO; GO:0051960; P:regulation of nervous system development; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0097374; P:sensory neuron axon guidance; IMP:MGI.
DR GO; GO:0021522; P:spinal cord motor neuron differentiation; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR031251; GBX-1.
DR InterPro; IPR042982; GBX-1/2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR24334; PTHR24334; 1.
DR PANTHER; PTHR24334:SF2; PTHR24334:SF2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..418
FT /note="Homeobox protein GBX-1"
FT /id="PRO_0000048879"
FT DNA_BIND 316..375
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..230
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 418 AA; 43710 MW; 77496E77B2A7B551 CRC64;
MSPEGDTPNP PARPLPPYER ESAAPEPHCA EPAPRRHLGP RARSEPCVSA RGARRGPGSA
MQRAAGGGAP GGSGGSSGGP GAAFSIDSLI GPPPPRSGHL LYTGYPMFMP YRPLVLPQAL
APAPLPAGLP PLAPLASFAG RLSNTFCAGL GQAVPSMVAL TTALPSFAEP PDAYYGPPEL
AAAAASTASR SNPEPAARRT DGALDAEELL PAREKVTEPP PPPPPHFSET FPSLPAEGKV
YSSDEEKLEP PAGDPAGSEQ EEEGSGGDSE DSFLDSSAGG PGALLGPKPK LKGSPGTGAE
EGTPVATGVT TPGGKSRRRR TAFTSEQLLE LEKEFHCKKY LSLTERSQIA HALKLSEVQV
KIWFQNRRAK WKRIKAGNVS SRSGEPVRNP KIVVPIPVHV NRFAVRSQHQ QMEQGARP
