ID   GBX2_CHICK              Reviewed;         340 AA.
AC   O42230;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Homeobox protein GBX-2;
DE   AltName: Full=Gastrulation and brain-specific homeobox protein 2;
GN   Name=GBX2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9346236; DOI=10.1016/s0092-8674(00)80401-8;
RA   Kowenz-Leutz E., Herr P., Niss K., Leutz A.;
RT   "The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine
RT   growth and monocyte differentiation.";
RL   Cell 91:185-195(1997).
CC   -!- FUNCTION: May act as a transcription factor for cell pluripotency and
CC       differentiation in the embryo.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; AF022151; AAB82710.1; -; mRNA.
DR   RefSeq; NP_990399.1; NM_205068.1.
DR   AlphaFoldDB; O42230; -.
DR   SMR; O42230; -.
DR   STRING; 9031.ENSGALP00000021739; -.
DR   PaxDb; O42230; -.
DR   GeneID; 395950; -.
DR   KEGG; gga:395950; -.
DR   CTD; 2637; -.
DR   VEuPathDB; HostDB:geneid_395950; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   InParanoid; O42230; -.
DR   OrthoDB; 1406210at2759; -.
DR   PhylomeDB; O42230; -.
DR   PRO; PR:O42230; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR   GO; GO:0048483; P:autonomic nervous system development; IEA:Ensembl.
DR   GO; GO:0007411; P:axon guidance; IEA:Ensembl.
DR   GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
DR   GO; GO:0021930; P:cerebellar granule cell precursor proliferation; IEA:Ensembl.
DR   GO; GO:0021549; P:cerebellum development; IEA:Ensembl.
DR   GO; GO:0021884; P:forebrain neuron development; IEA:Ensembl.
DR   GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR   GO; GO:0021555; P:midbrain-hindbrain boundary morphogenesis; IEA:Ensembl.
DR   GO; GO:0001755; P:neural crest cell migration; IEA:Ensembl.
DR   GO; GO:0051960; P:regulation of nervous system development; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0021568; P:rhombomere 2 development; IEA:Ensembl.
DR   GO; GO:0021794; P:thalamus development; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR042982; GBX-1/2.
DR   InterPro; IPR031250; GBX-2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR24334; PTHR24334; 1.
DR   PANTHER; PTHR24334:SF3; PTHR24334:SF3; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..340
FT                   /note="Homeobox protein GBX-2"
FT                   /id="PRO_0000048882"
FT   DNA_BIND        239..298
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          106..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          167..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        173..193
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   340 AA;  35856 MW;  B71423225904E741 CRC64;
     MSAAFQPSLM MMQRPLGSST AFSIDSLIGS PPPPAPGHFV YTGYPMFMPY RPVVLPPPPP
     ALPQAALQPP LPPAPPPPLP ALPGAFCPGL AQGMALTSTL MAALPGSFPA SPPRPEAARK
     FAPPGNFDKA DGLPPPDGGG GGGDDGKTGG GLLPFPAADA VHASLAGALR GGPKDDPKAE
     EEAKGREENF SMDSDLDYSS DENGPAPAAP REEDCGTALE ENPPSAANAA ANAAATGKNR
     RRRTAFTSEQ LLELEKEFHC KKYLSLTERS QIAHALKLSE VQVKIWFQNR RAKWKRVKAG
     NASSKAGEPS RNPKIVVPIP VHVSRFAIRS QHQQLEQARP