GBX2_MOUSE
ID GBX2_MOUSE Reviewed; 348 AA.
AC P48031; Q14A66;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Homeobox protein GBX-2;
DE AltName: Full=Gastrulation and brain-specific homeobox protein 2;
DE AltName: Full=Stimulated by retinoic acid gene 7 protein;
GN Name=Gbx2; Synonyms=Mmoxa, Stra7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8601031; DOI=10.1002/aja.1002040404;
RA Bouillet P., Chazaud C., Oulad Abdelghani M., Dolle P., Chambon P.;
RT "Sequence and expression pattern of the Stra7 (Gbx-2) homeobox-containing
RT gene induced by retinoic acid in P19 embryonal carcinoma cells.";
RL Dev. Dyn. 204:372-382(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129;
RX PubMed=9417909; DOI=10.1006/geno.1997.4969;
RA Chapman G., Remiszewski J.L., Webb G.C., Schulz T.C., Bottema C.D.K.,
RA Rathjen P.D.;
RT "The mouse homeobox gene, Gbx2: genomic organization and expression in
RT pluripotent cells in vitro and in vivo.";
RL Genomics 46:223-233(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 10-348.
RC STRAIN=129;
RX PubMed=7758585; DOI=10.1016/0014-5793(95)00410-b;
RA Chapman G., Rathjen P.D.;
RT "Sequence and evolutionary conservation of the murine Gbx-2 homeobox
RT gene.";
RL FEBS Lett. 364:289-292(1995).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 268-292.
RC STRAIN=C57BL/6J; TISSUE=Spleen;
RX PubMed=1720547; DOI=10.1073/pnas.88.23.10711;
RA Murtha M.T., Leckman J.F., Ruddle F.H.;
RT "Detection of homeobox genes in development and evolution.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:10711-10715(1991).
CC -!- FUNCTION: May act as a transcription factor for cell pluripotency and
CC differentiation in the embryo.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in adult brain, spleen and female genital
CC tract. No expression in heart, liver, lung, kidney, or testis.
CC -!- DEVELOPMENTAL STAGE: Expressed during gastrulation in the three
CC primitive germ layers and in the pharyngeal arches. In later stages,
CC expressed in the developing nervous system, midbrain/ hindbrain
CC boundary, cerebellum anlage, certain rhombomeres, regions of the spinal
CC cord, and in the developing dorsal thalamus and corpus striatum.
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DR EMBL; Z48800; CAA88737.1; -; mRNA.
DR EMBL; U74300; AAC61877.1; -; Genomic_DNA.
DR EMBL; BC116965; AAI16966.1; -; mRNA.
DR EMBL; BC120492; AAI20493.1; -; mRNA.
DR EMBL; L39770; AAA65185.1; -; mRNA.
DR EMBL; M81661; AAA63314.1; -; Genomic_DNA.
DR CCDS; CCDS15150.1; -.
DR PIR; S52720; S52720.
DR RefSeq; NP_034392.1; NM_010262.3.
DR AlphaFoldDB; P48031; -.
DR SMR; P48031; -.
DR STRING; 10090.ENSMUSP00000048508; -.
DR iPTMnet; P48031; -.
DR PhosphoSitePlus; P48031; -.
DR PaxDb; P48031; -.
DR PRIDE; P48031; -.
DR Antibodypedia; 20253; 330 antibodies from 35 providers.
DR DNASU; 14472; -.
DR Ensembl; ENSMUST00000036954; ENSMUSP00000048508; ENSMUSG00000034486.
DR GeneID; 14472; -.
DR KEGG; mmu:14472; -.
DR UCSC; uc007bzb.1; mouse.
DR CTD; 2637; -.
DR MGI; MGI:95668; Gbx2.
DR VEuPathDB; HostDB:ENSMUSG00000034486; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000154365; -.
DR HOGENOM; CLU_052189_0_0_1; -.
DR InParanoid; P48031; -.
DR OMA; QPSLMMM; -.
DR OrthoDB; 1406210at2759; -.
DR PhylomeDB; P48031; -.
DR TreeFam; TF351530; -.
DR BioGRID-ORCS; 14472; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Gbx2; mouse.
DR PRO; PR:P48031; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; P48031; protein.
DR Bgee; ENSMUSG00000034486; Expressed in animal zygote and 106 other tissues.
DR Genevisible; P48031; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IDA:MGI.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:MGI.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IDA:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0048483; P:autonomic nervous system development; IMP:MGI.
DR GO; GO:0007411; P:axon guidance; IMP:MGI.
DR GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IMP:MGI.
DR GO; GO:0021930; P:cerebellar granule cell precursor proliferation; IMP:MGI.
DR GO; GO:0021549; P:cerebellum development; IMP:MGI.
DR GO; GO:0021884; P:forebrain neuron development; IMP:MGI.
DR GO; GO:0030902; P:hindbrain development; IMP:MGI.
DR GO; GO:0042472; P:inner ear morphogenesis; IMP:MGI.
DR GO; GO:0030917; P:midbrain-hindbrain boundary development; IMP:MGI.
DR GO; GO:0021555; P:midbrain-hindbrain boundary morphogenesis; IMP:MGI.
DR GO; GO:0001755; P:neural crest cell migration; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0051960; P:regulation of nervous system development; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021568; P:rhombomere 2 development; IMP:MGI.
DR GO; GO:0021794; P:thalamus development; IMP:MGI.
DR GO; GO:0035239; P:tube morphogenesis; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR042982; GBX-1/2.
DR InterPro; IPR031250; GBX-2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR24334; PTHR24334; 1.
DR PANTHER; PTHR24334:SF3; PTHR24334:SF3; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..348
FT /note="Homeobox protein GBX-2"
FT /id="PRO_0000048881"
FT DNA_BIND 247..306
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 59..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 348 AA; 37359 MW; CF8594653EA8295B CRC64;
MSAAFPPSLM MMQRPLGSST AFSIDSLIGS PPQPSPGHFV YTGYPMFMPY RPVVLPPPPP
PPPALPQAAL QPALPPAHPH HQIPSLPTGF CSSLAQGMAL TSTLMATLPG GFSASPQHQE
AAAARKFAPQ PLPGGGNFDK AEALQADAED GKAFLAKEGS LLAFSAAEAV QASLVGAVRG
QGKDESKVED DPKGKEESFS LESDVDYSSD DNLPGQTAHK EEDPGHALEE TPQSGGAAGS
TTSTGKNRRR RTAFTSEQLL ELEKEFHCKK YLSLTERSQI AHALKLSEVQ VKIWFQNRRA
KWKRVKAGNA NSKTGEPSRN PKIVVPIPVH VSRFAIRSQH QQLEQARP
