ID   GBX2_XENLA              Reviewed;         340 AA.
AC   Q91907; Q91814;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Homeobox protein GBX-2;
DE   AltName: Full=Gastrulation and brain-specific homeobox protein 2;
DE   AltName: Full=XGBX-2;
GN   Name=gbx2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8652408; DOI=10.1016/0925-4773(95)00468-8;
RA   von Bubnoff A., Schmidt J.E., Kimelman D.;
RT   "The Xenopus laevis homeobox gene Xgbx-2 is an early marker of
RT   anteroposterior patterning in the ectoderm.";
RL   Mech. Dev. 54:149-160(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7937122; DOI=10.1093/nar/22.19.3990;
RA   King M.W., Moore M.J.;
RT   "Novel HOX, POU and FKH genes expressed during bFGF-induced mesodermal
RT   differentiation in Xenopus.";
RL   Nucleic Acids Res. 22:3990-3996(1994).
CC   -!- FUNCTION: May act as a transcription factor for cell pluripotency and
CC       differentiation in the embryo. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; L47990; AAA79290.1; -; mRNA.
DR   EMBL; U04867; AAA85029.1; -; mRNA.
DR   PIR; S53763; S53763.
DR   RefSeq; NP_001081416.1; NM_001087947.1.
DR   AlphaFoldDB; Q91907; -.
DR   SMR; Q91907; -.
DR   GeneID; 397824; -.
DR   KEGG; xla:397824; -.
DR   CTD; 397824; -.
DR   Xenbase; XB-GENE-866652; gbx2.2.L.
DR   OrthoDB; 1406210at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 397824; Expressed in neurula embryo and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR042982; GBX-1/2.
DR   InterPro; IPR031250; GBX-2.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR24334; PTHR24334; 1.
DR   PANTHER; PTHR24334:SF3; PTHR24334:SF3; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..340
FT                   /note="Homeobox protein GBX-2"
FT                   /id="PRO_0000048883"
FT   DNA_BIND        239..298
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          58..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          154..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          211..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..195
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..241
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        150
FT                   /note="T -> S (in Ref. 2; AAA85029)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   340 AA;  37195 MW;  2A368E10168451A7 CRC64;
     MSAAFQPPLM MMQRPLGSST AFSIDSLIGN PPQPSPGHFV YTGYPMFMPY RPVVLPPPPP
     PPPSLSQATL QSTLSSAHHH HPIPSLPGGF CSSLAQGMAL TSTLMATLPG GFSASTQHQE
     AARKFGAQSL HGAFEKSDGS QSDGEEGNKT YITKEGTLLP FSASEASLGP VRGQGKEESG
     KEAEGKGKED SYLMDSDLDY SSDDNISCQT AHKEEDTPEE SPQNSNPSNN SNTSSTGKNR
     RRRTAFTSEQ LLELEKEFHC KKYLSLTERS QIAHVLKLSE VQVKIWFQNR RAKWKRVKAG
     NTNSKTGEPS RNPKIVVPIP VHVNRFAIRS QHQQLEQARP