GBX2_XENLA
ID GBX2_XENLA Reviewed; 340 AA.
AC Q91907; Q91814;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Homeobox protein GBX-2;
DE AltName: Full=Gastrulation and brain-specific homeobox protein 2;
DE AltName: Full=XGBX-2;
GN Name=gbx2;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8652408; DOI=10.1016/0925-4773(95)00468-8;
RA von Bubnoff A., Schmidt J.E., Kimelman D.;
RT "The Xenopus laevis homeobox gene Xgbx-2 is an early marker of
RT anteroposterior patterning in the ectoderm.";
RL Mech. Dev. 54:149-160(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7937122; DOI=10.1093/nar/22.19.3990;
RA King M.W., Moore M.J.;
RT "Novel HOX, POU and FKH genes expressed during bFGF-induced mesodermal
RT differentiation in Xenopus.";
RL Nucleic Acids Res. 22:3990-3996(1994).
CC -!- FUNCTION: May act as a transcription factor for cell pluripotency and
CC differentiation in the embryo. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; L47990; AAA79290.1; -; mRNA.
DR EMBL; U04867; AAA85029.1; -; mRNA.
DR PIR; S53763; S53763.
DR RefSeq; NP_001081416.1; NM_001087947.1.
DR AlphaFoldDB; Q91907; -.
DR SMR; Q91907; -.
DR GeneID; 397824; -.
DR KEGG; xla:397824; -.
DR CTD; 397824; -.
DR Xenbase; XB-GENE-866652; gbx2.2.L.
DR OrthoDB; 1406210at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10L.
DR Bgee; 397824; Expressed in neurula embryo and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR042982; GBX-1/2.
DR InterPro; IPR031250; GBX-2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR24334; PTHR24334; 1.
DR PANTHER; PTHR24334:SF3; PTHR24334:SF3; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..340
FT /note="Homeobox protein GBX-2"
FT /id="PRO_0000048883"
FT DNA_BIND 239..298
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 58..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 150
FT /note="T -> S (in Ref. 2; AAA85029)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 340 AA; 37195 MW; 2A368E10168451A7 CRC64;
MSAAFQPPLM MMQRPLGSST AFSIDSLIGN PPQPSPGHFV YTGYPMFMPY RPVVLPPPPP
PPPSLSQATL QSTLSSAHHH HPIPSLPGGF CSSLAQGMAL TSTLMATLPG GFSASTQHQE
AARKFGAQSL HGAFEKSDGS QSDGEEGNKT YITKEGTLLP FSASEASLGP VRGQGKEESG
KEAEGKGKED SYLMDSDLDY SSDDNISCQT AHKEEDTPEE SPQNSNPSNN SNTSSTGKNR
RRRTAFTSEQ LLELEKEFHC KKYLSLTERS QIAHVLKLSE VQVKIWFQNR RAKWKRVKAG
NTNSKTGEPS RNPKIVVPIP VHVNRFAIRS QHQQLEQARP