GCC1_HUMAN
ID GCC1_HUMAN Reviewed; 775 AA.
AC Q96CN9; Q9H6N7;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=GRIP and coiled-coil domain-containing protein 1;
DE AltName: Full=Golgi coiled-coil protein 1;
GN Name=GCC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Cervix carcinoma;
RX PubMed=12446665; DOI=10.1074/jbc.m210387200;
RA Luke M.R., Kjer-Nielsen L., Brown D.L., Stow J.L., Gleeson P.A.;
RT "GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and
RT GCC185, to subcompartments of the trans-Golgi network.";
RL J. Biol. Chem. 278:4216-4226(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Skin, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 309-775.
RC TISSUE=Hepatoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=10209125; DOI=10.1016/s0960-9822(99)80168-7;
RA Kjer-Nielsen L., Teasdale R.D., van Vliet C., Gleeson P.A.;
RT "A novel Golgi-localisation domain shared by a class of coiled-coil
RT peripheral membrane proteins.";
RL Curr. Biol. 9:385-388(1999).
CC -!- FUNCTION: Probably involved in maintaining Golgi structure.
CC -!- INTERACTION:
CC Q96CN9; Q9NYB9: ABI2; NbExp=4; IntAct=EBI-746252, EBI-743598;
CC Q96CN9; P18848: ATF4; NbExp=6; IntAct=EBI-746252, EBI-492498;
CC Q96CN9; Q13490: BIRC2; NbExp=6; IntAct=EBI-746252, EBI-514538;
CC Q96CN9; Q6P1W5: C1orf94; NbExp=3; IntAct=EBI-746252, EBI-946029;
CC Q96CN9; Q86XR8: CEP57; NbExp=5; IntAct=EBI-746252, EBI-308614;
CC Q96CN9; Q86XR8-3: CEP57; NbExp=3; IntAct=EBI-746252, EBI-11752486;
CC Q96CN9; Q8NHQ1: CEP70; NbExp=6; IntAct=EBI-746252, EBI-739624;
CC Q96CN9; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-746252, EBI-11988027;
CC Q96CN9; Q96EY1-2: DNAJA3; NbExp=3; IntAct=EBI-746252, EBI-3952284;
CC Q96CN9; Q86UY5: FAM83A; NbExp=3; IntAct=EBI-746252, EBI-1384254;
CC Q96CN9; Q9NVF7: FBXO28; NbExp=3; IntAct=EBI-746252, EBI-740282;
CC Q96CN9; Q6PIW4: FIGNL1; NbExp=3; IntAct=EBI-746252, EBI-8468390;
CC Q96CN9; P15407: FOSL1; NbExp=3; IntAct=EBI-746252, EBI-744510;
CC Q96CN9; O95995: GAS8; NbExp=3; IntAct=EBI-746252, EBI-1052570;
CC Q96CN9; P08151: GLI1; NbExp=3; IntAct=EBI-746252, EBI-308084;
CC Q96CN9; Q08379: GOLGA2; NbExp=6; IntAct=EBI-746252, EBI-618309;
CC Q96CN9; Q7Z353: HDX; NbExp=3; IntAct=EBI-746252, EBI-1052734;
CC Q96CN9; Q8NDH6-2: ICA1L; NbExp=3; IntAct=EBI-746252, EBI-12141931;
CC Q96CN9; Q9BW62: KATNAL1; NbExp=3; IntAct=EBI-746252, EBI-743591;
CC Q96CN9; O60341: KDM1A; NbExp=3; IntAct=EBI-746252, EBI-710124;
CC Q96CN9; Q2KHM9: KIAA0753; NbExp=3; IntAct=EBI-746252, EBI-2805604;
CC Q96CN9; P33176: KIF5B; NbExp=3; IntAct=EBI-746252, EBI-355878;
CC Q96CN9; Q86VQ0: LCA5; NbExp=3; IntAct=EBI-746252, EBI-6658186;
CC Q96CN9; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-746252, EBI-741037;
CC Q96CN9; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-746252, EBI-348259;
CC Q96CN9; Q9NPJ6: MED4; NbExp=3; IntAct=EBI-746252, EBI-394607;
CC Q96CN9; P50221: MEOX1; NbExp=3; IntAct=EBI-746252, EBI-2864512;
CC Q96CN9; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-746252, EBI-10172526;
CC Q96CN9; Q15742: NAB2; NbExp=3; IntAct=EBI-746252, EBI-8641936;
CC Q96CN9; Q8NEY1-3: NAV1; NbExp=3; IntAct=EBI-746252, EBI-11953718;
CC Q96CN9; Q8NEY1-4: NAV1; NbExp=3; IntAct=EBI-746252, EBI-10270828;
CC Q96CN9; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-746252, EBI-10172876;
CC Q96CN9; O43482: OIP5; NbExp=3; IntAct=EBI-746252, EBI-536879;
CC Q96CN9; Q9P286: PAK5; NbExp=3; IntAct=EBI-746252, EBI-741896;
CC Q96CN9; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-746252, EBI-2557469;
CC Q96CN9; Q86WC6: PPP1R27; NbExp=3; IntAct=EBI-746252, EBI-5235602;
CC Q96CN9; Q99633: PRPF18; NbExp=3; IntAct=EBI-746252, EBI-2798416;
CC Q96CN9; Q01196-8: RUNX1; NbExp=3; IntAct=EBI-746252, EBI-12001422;
CC Q96CN9; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-746252, EBI-1105213;
CC Q96CN9; Q08117-2: TLE5; NbExp=3; IntAct=EBI-746252, EBI-11741437;
CC Q96CN9; Q05BL1: TP53BP2; NbExp=3; IntAct=EBI-746252, EBI-11952721;
CC Q96CN9; Q14134: TRIM29; NbExp=2; IntAct=EBI-746252, EBI-702370;
CC Q96CN9; Q86XT4: TRIM50; NbExp=3; IntAct=EBI-746252, EBI-9867283;
CC Q96CN9; Q5TAP6: UTP14C; NbExp=3; IntAct=EBI-746252, EBI-11737646;
CC Q96CN9; P98170: XIAP; NbExp=3; IntAct=EBI-746252, EBI-517127;
CC Q96CN9; Q9NQZ6: ZC4H2; NbExp=3; IntAct=EBI-746252, EBI-747993;
CC Q96CN9; Q8TF47: ZFP90; NbExp=3; IntAct=EBI-746252, EBI-11419867;
CC Q96CN9; Q8N554-2: ZNF276; NbExp=3; IntAct=EBI-746252, EBI-10265849;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10209125}. Golgi
CC apparatus membrane {ECO:0000250}; Peripheral membrane protein
CC {ECO:0000250}.
CC -!- DOMAIN: Extended rod-like protein with coiled-coil domains.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH08902.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC Sequence=BAB15218.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF525417; AAM91948.1; -; mRNA.
DR EMBL; BC008902; AAH08902.2; ALT_SEQ; mRNA.
DR EMBL; BC014100; AAH14100.1; -; mRNA.
DR EMBL; BC078665; AAH78665.1; -; mRNA.
DR EMBL; AK025688; BAB15218.1; ALT_INIT; mRNA.
DR CCDS; CCDS5796.1; -.
DR RefSeq; NP_078799.2; NM_024523.5.
DR AlphaFoldDB; Q96CN9; -.
DR SMR; Q96CN9; -.
DR BioGRID; 122718; 106.
DR IntAct; Q96CN9; 91.
DR MINT; Q96CN9; -.
DR STRING; 9606.ENSP00000318821; -.
DR iPTMnet; Q96CN9; -.
DR MetOSite; Q96CN9; -.
DR PhosphoSitePlus; Q96CN9; -.
DR BioMuta; GCC1; -.
DR DMDM; 32699595; -.
DR EPD; Q96CN9; -.
DR jPOST; Q96CN9; -.
DR MassIVE; Q96CN9; -.
DR MaxQB; Q96CN9; -.
DR PaxDb; Q96CN9; -.
DR PeptideAtlas; Q96CN9; -.
DR PRIDE; Q96CN9; -.
DR ProteomicsDB; 76200; -.
DR Antibodypedia; 17726; 161 antibodies from 22 providers.
DR DNASU; 79571; -.
DR Ensembl; ENST00000321407.3; ENSP00000318821.2; ENSG00000179562.3.
DR GeneID; 79571; -.
DR KEGG; hsa:79571; -.
DR MANE-Select; ENST00000321407.3; ENSP00000318821.2; NM_024523.6; NP_078799.2.
DR UCSC; uc003vma.4; human.
DR CTD; 79571; -.
DR DisGeNET; 79571; -.
DR GeneCards; GCC1; -.
DR HGNC; HGNC:19095; GCC1.
DR HPA; ENSG00000179562; Low tissue specificity.
DR MIM; 607418; gene.
DR neXtProt; NX_Q96CN9; -.
DR OpenTargets; ENSG00000179562; -.
DR PharmGKB; PA38796; -.
DR VEuPathDB; HostDB:ENSG00000179562; -.
DR eggNOG; ENOG502QQ2S; Eukaryota.
DR GeneTree; ENSGT00940000153772; -.
DR HOGENOM; CLU_020679_0_0_1; -.
DR InParanoid; Q96CN9; -.
DR OMA; HMLHYAN; -.
DR OrthoDB; 979102at2759; -.
DR PhylomeDB; Q96CN9; -.
DR TreeFam; TF324186; -.
DR PathwayCommons; Q96CN9; -.
DR Reactome; R-HSA-6811440; Retrograde transport at the Trans-Golgi-Network.
DR SignaLink; Q96CN9; -.
DR SIGNOR; Q96CN9; -.
DR BioGRID-ORCS; 79571; 13 hits in 1085 CRISPR screens.
DR ChiTaRS; GCC1; human.
DR GeneWiki; GCC1; -.
DR GenomeRNAi; 79571; -.
DR Pharos; Q96CN9; Tbio.
DR PRO; PR:Q96CN9; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q96CN9; protein.
DR Bgee; ENSG00000179562; Expressed in secondary oocyte and 192 other tissues.
DR ExpressionAtlas; Q96CN9; baseline and differential.
DR Genevisible; Q96CN9; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000138; C:Golgi trans cisterna; ISS:FlyBase.
DR GO; GO:0031267; F:small GTPase binding; ISS:FlyBase.
DR InterPro; IPR000237; GRIP_dom.
DR Pfam; PF01465; GRIP; 1.
DR SMART; SM00755; Grip; 1.
DR PROSITE; PS50913; GRIP; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Golgi apparatus; Membrane; Reference proteome.
FT CHAIN 1..775
FT /note="GRIP and coiled-coil domain-containing protein 1"
FT /id="PRO_0000190072"
FT DOMAIN 713..763
FT /note="GRIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00250"
FT REGION 84..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..61
FT /evidence="ECO:0000255"
FT COILED 153..763
FT /evidence="ECO:0000255"
FT COMPBIAS 92..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 86
FT /note="R -> W (in dbSNP:rs17151044)"
FT /id="VAR_021902"
FT VARIANT 87
FT /note="C -> W (in dbSNP:rs2285348)"
FT /id="VAR_020157"
FT VARIANT 122
FT /note="A -> V (in dbSNP:rs35322201)"
FT /id="VAR_049259"
FT VARIANT 262
FT /note="Q -> R (in dbSNP:rs35390108)"
FT /id="VAR_049260"
FT VARIANT 274
FT /note="A -> T (in dbSNP:rs34887879)"
FT /id="VAR_049261"
FT VARIANT 618
FT /note="R -> C (in dbSNP:rs34883586)"
FT /id="VAR_049262"
SQ SEQUENCE 775 AA; 87811 MW; ED72FF26BDF8DAD6 CRC64;
MEKFGMNFGG GPSKKDLLET IETQKKQLLQ YQARLKDVVR AYKSLLKEKE ALEASIKVLS
VSHEADVGLA GVQLPGLTFP DSVDDRCSTH SEDSTGTATS LDTAASLTST KGEFGVEDDR
PARGPPPPKS EEASWSESGV SSSSGDGPFA GGEVDKRLHQ LKTQLATLTS SLATVTQEKS
RMEASYLADK KKMKQDLEDA SNKAEEERAR LEGELKGLQE QIAETKARLI TQQHDRAQEQ
SDHALMLREL QKLLQEERTQ RQDLELRLEE TREALAGRAY AAEQMEGFEL QTKQLTREVE
ELKSELQAIR DEKNQPDPRL QELQEEAARL KSHFQAQLQQ EMRKTALAED QLRQQSQVEE
QRVAALENQI SEVSELLGTY EKAKQKDQLA IQKLKERILQ LDLENKTLAL AASSRSPLDS
HGEESSLDVN VLKDKMEKLK RLLQVAARKS QVTLDVEKLC DLEIMPSSEA ADGEKATALY
YQQELKQLKE EFERYKMRAQ VVLKSKNTKD GNLGKELEAA QEQLAELKEK YISLRLSCEE
LEHQHQQEAD DWKQELARLQ QLHRQELERC QLDFRDRTLK LEEELHKQRD RALAVLTEKD
LELEQLRSVA LASGLPGRRS PVGGGGPGDP ADTSSSDSLT QALQLAAANE PTFFLYAEQL
ARKEVEITSL RKQKHRLEVE VHQLQDRLLE EGERHREEVA ALQSHIEKNI RDQSREGANL
EYLKNIIYRF LTLPDSLGRQ QTLTAILTIL HFSPEEKQVI MRLPTSASWW PSGKR
