GCC1_MOUSE
ID GCC1_MOUSE Reviewed; 778 AA.
AC Q9D4H2; Q8CCR3;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2003, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=GRIP and coiled-coil domain-containing protein 1;
DE AltName: Full=Golgi coiled-coil protein 1;
GN Name=Gcc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CD-1; TISSUE=Neural stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 345-353, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Probably involved in maintaining Golgi structure.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC -!- DOMAIN: Extended rod-like protein with coiled-coil domains.
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DR EMBL; AK032253; BAC27780.1; -; mRNA.
DR EMBL; BC066807; AAH66807.1; -; mRNA.
DR CCDS; CCDS19951.1; -.
DR RefSeq; NP_083176.3; NM_028900.4.
DR AlphaFoldDB; Q9D4H2; -.
DR SMR; Q9D4H2; -.
DR STRING; 10090.ENSMUSP00000087997; -.
DR iPTMnet; Q9D4H2; -.
DR PhosphoSitePlus; Q9D4H2; -.
DR EPD; Q9D4H2; -.
DR MaxQB; Q9D4H2; -.
DR PaxDb; Q9D4H2; -.
DR PeptideAtlas; Q9D4H2; -.
DR PRIDE; Q9D4H2; -.
DR ProteomicsDB; 267777; -.
DR Antibodypedia; 17726; 161 antibodies from 22 providers.
DR Ensembl; ENSMUST00000064377; ENSMUSP00000067395; ENSMUSG00000029708.
DR Ensembl; ENSMUST00000090511; ENSMUSP00000087997; ENSMUSG00000029708.
DR GeneID; 74375; -.
DR KEGG; mmu:74375; -.
DR UCSC; uc009bco.2; mouse.
DR CTD; 79571; -.
DR MGI; MGI:1921625; Gcc1.
DR VEuPathDB; HostDB:ENSMUSG00000029708; -.
DR eggNOG; ENOG502QQ2S; Eukaryota.
DR GeneTree; ENSGT00940000153772; -.
DR HOGENOM; CLU_020679_0_0_1; -.
DR InParanoid; Q9D4H2; -.
DR OMA; HMLHYAN; -.
DR OrthoDB; 979102at2759; -.
DR PhylomeDB; Q9D4H2; -.
DR TreeFam; TF324186; -.
DR Reactome; R-MMU-6811440; Retrograde transport at the Trans-Golgi-Network.
DR BioGRID-ORCS; 74375; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Gcc1; mouse.
DR PRO; PR:Q9D4H2; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9D4H2; protein.
DR Bgee; ENSMUSG00000029708; Expressed in granulocyte and 231 other tissues.
DR ExpressionAtlas; Q9D4H2; baseline and differential.
DR Genevisible; Q9D4H2; MM.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR000237; GRIP_dom.
DR Pfam; PF01465; GRIP; 1.
DR SMART; SM00755; Grip; 1.
DR PROSITE; PS50913; GRIP; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Direct protein sequencing; Golgi apparatus;
KW Membrane; Reference proteome.
FT CHAIN 1..778
FT /note="GRIP and coiled-coil domain-containing protein 1"
FT /id="PRO_0000190073"
FT DOMAIN 716..766
FT /note="GRIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00250"
FT REGION 70..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 617..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..61
FT /evidence="ECO:0000255"
FT COILED 152..702
FT /evidence="ECO:0000255"
FT COMPBIAS 92..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 456
FT /note="V -> M (in Ref. 1; BAC27780)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 778 AA; 87678 MW; 10443331CB480A2B CRC64;
MEKFGMNFGG GPSKKDLLET IETQKKQLLQ YQARLKDVVR AYKSLLKEKE ALEASIKVLS
VSHEADVGLS GVQPPGLTFP DSVDDRCSTH SEDSTGTATS LDTAASLTSV KGEFGVEDDR
AARGPLPPKS EEASGSESGV SSSSGDGPSA GSEMDKRVHQ LKTQLATLTS SLATVTQEKS
RMEASYLADK KKMKQDLEDA NKKAEEERGR LEGDLKVLQE QIAETKARLI TQQHDRAQEQ
SDHALMLREL QKLLQEERTQ RQDLELRLEE TREALAGRAY AADQVEGFEL QTKQLTREVE
ELKGELQTIR DEKNRPDPRL QELQQEAARL KSHFQAQLQQ EMRKTALAED QLRQQSQVEE
QRVAALESQI SEVSELLGTY EKAKQKDQLA IQKLKERLLQ LDLENKTLAL AASSRSSLDI
HGDESSLDIN VLKDKMEKLK KLLQVAARKS QVTLDVEKLC DPEIMANSEA ADGEKATALY
YQQELKQLKE EFERYKMRAQ VVLKSKNTKD GSLGKELEAA QEQLAELKDK YISLRLSCEE
LESQHQQEAE DWKQELARLQ QLHRQELERS QLDFRDRTLK LEEELHKQRD RALAVLAEKD
LELEQLRSVA LSSGLPGRRS PVGGVGGGGL GDPADTASSD SLTQALQLAA ANEPTFFLYA
EQLARKEVEI TSLRKQKHRL EVEAHQLQER LLEEGERHRE EVGALQSHIE KNMRDQSREG
ANLEYLKNII YRFLTLPDSL GRQQTLTAIL TILHFSPEEK QVLMRLPSGG SWWPSGKR
