ID   GCC2_CAEEL              Reviewed;         660 AA.
AC   P34562; Q86DA2;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2004, sequence version 3.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=GRIP and coiled-coil domain-containing protein 2 {ECO:0000312|WormBase:T05G5.9a};
GN   Name=gcc-2 {ECO:0000312|WormBase:T05G5.9a};
GN   ORFNames=T05G5.9 {ECO:0000312|WormBase:T05G5.9a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=P34562-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=P34562-2; Sequence=VSP_009679;
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DR   EMBL; Z27079; CAA81596.2; -; Genomic_DNA.
DR   EMBL; Z27079; CAD90180.1; -; Genomic_DNA.
DR   PIR; E88564; E88564.
DR   PIR; S41009; S41009.
DR   RefSeq; NP_001022748.1; NM_001027577.3. [P34562-1]
DR   RefSeq; NP_001022749.1; NM_001027578.3. [P34562-2]
DR   AlphaFoldDB; P34562; -.
DR   SMR; P34562; -.
DR   BioGRID; 41573; 4.
DR   IntAct; P34562; 2.
DR   STRING; 6239.T05G5.9a; -.
DR   iPTMnet; P34562; -.
DR   EPD; P34562; -.
DR   PaxDb; P34562; -.
DR   PeptideAtlas; P34562; -.
DR   EnsemblMetazoa; T05G5.9a.1; T05G5.9a.1; WBGene00011503. [P34562-1]
DR   EnsemblMetazoa; T05G5.9b.1; T05G5.9b.1; WBGene00011503. [P34562-2]
DR   GeneID; 176378; -.
DR   KEGG; cel:CELE_T05G5.9; -.
DR   UCSC; T05G5.9a; c. elegans. [P34562-1]
DR   CTD; 176378; -.
DR   WormBase; T05G5.9a; CE34088; WBGene00011503; gcc-2. [P34562-1]
DR   WormBase; T05G5.9b; CE34089; WBGene00011503; gcc-2. [P34562-2]
DR   eggNOG; ENOG502SAHV; Eukaryota.
DR   GeneTree; ENSGT00940000153772; -.
DR   HOGENOM; CLU_027458_0_0_1; -.
DR   InParanoid; P34562; -.
DR   OMA; MKFIAPE; -.
DR   OrthoDB; 200498at2759; -.
DR   PhylomeDB; P34562; -.
DR   SignaLink; P34562; -.
DR   PRO; PR:P34562; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00011503; Expressed in adult organism and 4 other tissues.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   InterPro; IPR032023; GCC2_Rab_bind.
DR   InterPro; IPR000237; GRIP_dom.
DR   Pfam; PF01465; GRIP; 1.
DR   Pfam; PF16704; Rab_bind; 1.
DR   SMART; SM00755; Grip; 1.
DR   PROSITE; PS50913; GRIP; 1.
PE   4: Predicted;
KW   Alternative splicing; Coiled coil; Reference proteome.
FT   CHAIN           1..660
FT                   /note="GRIP and coiled-coil domain-containing protein 2"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000190077"
FT   DOMAIN          585..636
FT                   /note="GRIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00250"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          30..92
FT                   /evidence="ECO:0000255"
FT   COILED          115..464
FT                   /evidence="ECO:0000255"
FT   COILED          517..596
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         89..90
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_009679"
SQ   SEQUENCE   660 AA;  75039 MW;  F00E793A4DB3038C CRC64;
     MSAPESSISP VPPPGSSSGG GKKLDSLPKE DLVKFAKKQV AHVAEMKKNQ TALMEKLKAK
     MSELEQVKKD AENLKLINEK LTTESAKKVE NNPTECTECL SKSGALIELE KEVFEWKEKA
     TRADMISLEL RDLESKVDQL NRALRDKTEA LIKAQEVITE NDLEVNNMKK EKNNTKSSIE
     KLTEENTRLT KALQDEKIKS ADFEARLRSA ECRIVELSDQ QGNEKLGLAR KMAESENRGR
     ILEEAVDVLK SENEKLLAKN EEFSAKLVSS EKEFAEFKKK SHFVLEKKGK QEDETRKAIE
     KLEKSKVTIT ELEQQADQTR QEHFKTVEDL ASSRDKAERL EKTLKVLKSE LTESEKAHTT
     AIDELQSSSS KLIQRLDEEL RLMRSSRDTA EQKIKDIEIA KEKVDHLLQN ERQRSENENG
     SLKSKLSSAT KQIHSLEKEL QELRNDFETR RIQSNQHQQQ KAIAAVVPQP IQLPEHPIPP
     LHYQRPAVAP SDSVSCYDEP TQPDRSLEDV LYGDLGDEYR VESDELSEEK FKVILDQLEN
     LKKTNHHVAE LLSDAETANG RLTTQNSLLK DEIRRLEREE KREAELSNEK NMEYLKNVFV
     QFLKPESVPA ERDQLVIVLQ RVLHLSPKEV EILKAASAHM ATAQAGSWSS YFSGWSGAAT