ID   GCH1L_STRPN             Reviewed;         265 AA.
AC   Q97PK0;
DT   15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=GTP cyclohydrolase 1 type 2 homolog;
GN   OrderedLocusNames=SP_1609;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS), AND SUBUNIT.
RC   STRAIN=ATCC BAA-334 / TIGR4;
RG   Midwest center for structural genomics (MCSG);
RT   "Crystal structure of a conserved hypothetical protein from Streptococcus
RT   pneumoniae TIGR4.";
RL   Submitted (JUL-2011) to the PDB data bank.
CC   -!- SUBUNIT: Homohexamer. {ECO:0000269|Ref.2}.
CC   -!- SIMILARITY: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
CC       {ECO:0000305}.
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DR   EMBL; AE005672; AAK75693.1; -; Genomic_DNA.
DR   PIR; D95187; D95187.
DR   RefSeq; WP_000881169.1; NZ_AKVY01000001.1.
DR   PDB; 2FYW; X-ray; 2.40 A; A/B/C=1-265.
DR   PDBsum; 2FYW; -.
DR   AlphaFoldDB; Q97PK0; -.
DR   SMR; Q97PK0; -.
DR   STRING; 170187.SP_1609; -.
DR   EnsemblBacteria; AAK75693; AAK75693; SP_1609.
DR   KEGG; spn:SP_1609; -.
DR   eggNOG; COG0327; Bacteria.
DR   OMA; HGLFWRG; -.
DR   PhylomeDB; Q97PK0; -.
DR   BioCyc; SPNE170187:G1FZB-1630-MON; -.
DR   EvolutionaryTrace; Q97PK0; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR002678; DUF34/NIF3.
DR   InterPro; IPR036069; DUF34/NIF3_sf.
DR   PANTHER; PTHR13799; PTHR13799; 1.
DR   Pfam; PF01784; NIF3; 1.
DR   SUPFAM; SSF102705; SSF102705; 1.
DR   TIGRFAMs; TIGR00486; YbgI_SA1388; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Metal-binding.
FT   CHAIN           1..265
FT                   /note="GTP cyclohydrolase 1 type 2 homolog"
FT                   /id="PRO_0000147336"
FT   BINDING         65
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P0AFP6"
FT   BINDING         103
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P0AFP6"
FT   BINDING         225
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P0AFP6"
FT   BINDING         228
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:P0AFP6"
FT   BINDING         228
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:P0AFP6"
FT   HELIX           3..13
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   HELIX           16..18
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   STRAND          26..30
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   STRAND          32..35
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   STRAND          37..43
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   HELIX           47..55
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   STRAND          59..65
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   HELIX           80..90
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   STRAND          94..97
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   HELIX           100..104
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   HELIX           109..117
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   STRAND          120..129
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   STRAND          132..144
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   HELIX           145..155
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   STRAND          162..164
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   HELIX           170..172
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   STRAND          173..184
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   HELIX           186..188
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   HELIX           189..194
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   STRAND          198..203
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   HELIX           207..215
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   STRAND          219..222
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   HELIX           225..229
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   HELIX           230..246
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   STRAND          251..254
FT                   /evidence="ECO:0007829|PDB:2FYW"
FT   STRAND          262..264
FT                   /evidence="ECO:0007829|PDB:2FYW"
SQ   SEQUENCE   265 AA;  29823 MW;  7FE424DD4FEE9F5C CRC64;
     MLASEVIQAY EAFCPQEFSM EGDSRGLQIG TLDKGIQRVM VALDIREETV AEAIEKGVDL
     IIVKHAPIFR PIKDLLASRP QNQIYIDLIK HDIAVYVSHT NIDIVENGLN DWFCQMLGIE
     ETTYLQETGP ERGIGRIGNI QPQTFWELAQ QVKQVFDLDS LRMVHYQEDD LQKPISRVAI
     CGGSGQSFYK DALAKGADVY ITGDIYYHTA QDMLSDGLLA LDPGHYIEVI FVEKIAALLS
     QWKEDKGWSI DILPSQASTN PFHHI