ID   3NOJ6_DENJA             Reviewed;          63 AA.
AC   P25682;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Toxin S6C6 {ECO:0000303|Ref.1};
OS   Dendroaspis jamesoni kaimosae (Eastern Jameson's mamba).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Dendroaspis.
OX   NCBI_TaxID=8619;
RN   [1]
RP   PROTEIN SEQUENCE, TOXIC DOSE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RA   Joubert F.J., Taljaard N.;
RT   "Complete primary structure of toxin S6C6 from Dendroaspis jamesoni
RT   kaimosae (Jameson's mamba).";
RL   S. Afr. J. Chem. 32:151-155(1979).
CC   -!- FUNCTION: May enhance presynaptic acetylcholine release.
CC       {ECO:0000250|UniProtKB:P81782}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- TOXIC DOSE: LD(50) is 10 mg/kg by intravenous injection.
CC       {ECO:0000269|Ref.1}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Ancestral
CC       subfamily. Orphan group XIX sub-subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P25682; -.
DR   SMR; P25682; -.
DR   PRIDE; P25682; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Neurotoxin;
KW   Presynaptic neurotoxin; Secreted; Toxin.
FT   CHAIN           1..63
FT                   /note="Toxin S6C6"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000093662"
FT   DISULFID        3..24
FT                   /evidence="ECO:0000250|UniProtKB:P81782"
FT   DISULFID        6..11
FT                   /evidence="ECO:0000250|UniProtKB:P81782"
FT   DISULFID        17..39
FT                   /evidence="ECO:0000250|UniProtKB:P81782"
FT   DISULFID        43..55
FT                   /evidence="ECO:0000250|UniProtKB:P81782"
FT   DISULFID        56..61
FT                   /evidence="ECO:0000250|UniProtKB:P81782"
SQ   SEQUENCE   63 AA;  7398 MW;  78A92F0E7661A0A8 CRC64;
     LECYRCGVSG CHLRTTCSAK EKFCAKQHNR ISTLWWHGCV ETCTEDETWK FYRKCCTTNL
     CNI