GCH1_SYNE7
ID GCH1_SYNE7 Reviewed; 213 AA.
AC Q54769; Q31MU2; Q8KPT2;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 10-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=GTP cyclohydrolase 1;
DE EC=3.5.4.16;
DE AltName: Full=GTP cyclohydrolase I;
DE Short=GTP-CH-I;
GN Name=folE; OrderedLocusNames=Synpcc7942_1597; ORFNames=sec0031;
OS Synechococcus elongatus (strain PCC 7942 / FACHB-805) (Anacystis nidulans
OS R2).
OC Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX NCBI_TaxID=1140;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Phung L.T., Haselkorn R.;
RT "Genes encoding the alpha subunit of carboxyltransferase of the acetyl-CoA
RT carboxylase complex and GTP cyclohydrolase I from cyanobacterium
RT Synechococcus sp. PCC 7942.";
RL Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Holtman C.K., Sandoval P., Chen Y., Socias T., Mohler B.J., Gonzalez A.,
RA Salinas I., McMurtry S., Golden S.S., Youderian P.;
RT "Synechococcus elongatus PCC7942 cosmid 6C3.";
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC 7942 / FACHB-805;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M.,
RA Kyrpides N., Lykidis A., Richardson P.;
RT "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate +
CC H(+); Xref=Rhea:RHEA:17473, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15740, ChEBI:CHEBI:37565, ChEBI:CHEBI:58462; EC=3.5.4.16;
CC -!- PATHWAY: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate
CC biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.
CC -!- SUBUNIT: Toroid-shaped homodecamer, composed of two pentamers of five
CC dimers. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GTP cyclohydrolase I family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB82043.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAM82644.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U59236; AAB82043.1; ALT_INIT; Genomic_DNA.
DR EMBL; AY120852; AAM82644.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP000100; ABB57627.1; -; Genomic_DNA.
DR RefSeq; WP_011242367.1; NC_007604.1.
DR AlphaFoldDB; Q54769; -.
DR SMR; Q54769; -.
DR STRING; 1140.Synpcc7942_1597; -.
DR PRIDE; Q54769; -.
DR EnsemblBacteria; ABB57627; ABB57627; Synpcc7942_1597.
DR KEGG; syf:Synpcc7942_1597; -.
DR eggNOG; COG0302; Bacteria.
DR HOGENOM; CLU_049768_2_2_3; -.
DR OMA; YHETIYD; -.
DR OrthoDB; 1632367at2; -.
DR BioCyc; SYNEL:SYNPCC7942_1597-MON; -.
DR UniPathway; UPA00848; UER00151.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003934; F:GTP cyclohydrolase I activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0035998; P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.286.10; -; 1.
DR Gene3D; 3.30.1130.10; -; 1.
DR HAMAP; MF_00223; FolE; 1.
DR InterPro; IPR043133; GTP-CH-I_C/QueF.
DR InterPro; IPR043134; GTP-CH-I_N.
DR InterPro; IPR001474; GTP_CycHdrlase_I.
DR InterPro; IPR018234; GTP_CycHdrlase_I_CS.
DR InterPro; IPR020602; GTP_CycHdrlase_I_dom.
DR PANTHER; PTHR11109; PTHR11109; 1.
DR Pfam; PF01227; GTP_cyclohydroI; 1.
DR TIGRFAMs; TIGR00063; folE; 1.
DR PROSITE; PS00859; GTP_CYCLOHYDROL_1_1; 1.
DR PROSITE; PS00860; GTP_CYCLOHYDROL_1_2; 1.
PE 3: Inferred from homology;
KW GTP-binding; Hydrolase; Metal-binding; Nucleotide-binding;
KW One-carbon metabolism; Zinc.
FT CHAIN 1..213
FT /note="GTP cyclohydrolase 1"
FT /id="PRO_0000119457"
FT BINDING 98
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 101
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 169
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
SQ SEQUENCE 213 AA; 23715 MW; 4DA8E3F94B84BE45 CRC64;
MTSPSLNGSN SLVDAIRPET EAVSQAEMEA AVRTLLLGVG EDPEREGLLK TPKRVAEAYR
FLTSGYSQSL DDLVNGAIFD EGHNEMVLVR DITAFSLCEH HMLPFMGKVH VAYIPNQKVV
GLSKLARIVE MYSRRLQVQE RLTRQIAESV QEILDPQGVA VVMEATHMCM VMRGVQKPGS
WTVTSAMVGV FQEDQRTREE FLSLIRHQPA AFA
